Procalcitonin as a diagnostic marker and IL-6 as a prognostic marker for sepsis

Dong Wook Jekarl; So Young Lee; Jehoon Lee; Yeon Joon Park; Yonggoo Kim; Jeong Ho Park; Jung Hee Wee; Seung Pill Choi

doi:10.1016/j.diagmicrobio.2012.12.011

Procalcitonin as a diagnostic marker and IL-6 as a prognostic marker for sepsis

Dong Wook Jekarl, So Young Lee, Jehoon Lee, Yeon Joon Park, Yonggoo Kim, Jeong Ho Park, Jung Hee Wee, Seung Pill Choi

The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

153 Scopus citations

Abstract

The diagnosis and prognosis of sepsis after antimicrobial therapy among systemic inflammatory response syndrome (SIRS) patients were evaluated with the biomarkers procalcitonin (PCT), interleukin-6 (IL-6), C-reactive protein (CRP), erythrocyte sedimentation rate, and white blood cell counts.Among 177 consecutive SIRS patients, 78 exhibited sepsis, with Escherichia coli (23.1%) being the most common pathogen. PCT showed the best diagnostic performance, with 74.4% and 93.7% sensitivity and 86.7% and 75.2% specificity among sepsis and severe sepsis/septic shock patients, respectively. PCT, IL-6, and CRP levels were significantly increased in nonsurvivors compared to survivors. Serial measurements at 0, 12, 24, 48, 72, and 96 h showed that IL-6 showed better kinetics in the survivor group and was decreased in more than 86% of survivors by the second day.PCT can support the diagnosis of bacterial infection, especially in septic shock and severe sepsis patients. IL6 exhibited the better kinetics for monitoring the effectiveness of antibiotic treatment.

Original language	English
Pages (from-to)	342-347
Number of pages	6
Journal	Diagnostic Microbiology and Infectious Disease
Volume	75
Issue number	4
DOIs	https://doi.org/10.1016/j.diagmicrobio.2012.12.011
State	Published - Apr 2013

Bibliographical note

Funding Information:
The authors thank Yeon-Ju An, Jung soon Kim, and Mi-Ran Lee for excellent technical assistance. This study was supported by the Yeouido St. Mary's Hospital Clinical Research Center, The Catholic University of Korea . The authors also thank the center for assistance. Part of the IL-6 diagnostic kit was a generous gift from Sa-Gang Lab. Tech. Co., Ltd.

Keywords

C-reactive protein
Interleukin-6
Procalcitonin
Sepsis
Systemic inflammatory response syndrome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diagmicrobio.2012.12.011

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title = "Procalcitonin as a diagnostic marker and IL-6 as a prognostic marker for sepsis",

abstract = "The diagnosis and prognosis of sepsis after antimicrobial therapy among systemic inflammatory response syndrome (SIRS) patients were evaluated with the biomarkers procalcitonin (PCT), interleukin-6 (IL-6), C-reactive protein (CRP), erythrocyte sedimentation rate, and white blood cell counts.Among 177 consecutive SIRS patients, 78 exhibited sepsis, with Escherichia coli (23.1%) being the most common pathogen. PCT showed the best diagnostic performance, with 74.4% and 93.7% sensitivity and 86.7% and 75.2% specificity among sepsis and severe sepsis/septic shock patients, respectively. PCT, IL-6, and CRP levels were significantly increased in nonsurvivors compared to survivors. Serial measurements at 0, 12, 24, 48, 72, and 96 h showed that IL-6 showed better kinetics in the survivor group and was decreased in more than 86% of survivors by the second day.PCT can support the diagnosis of bacterial infection, especially in septic shock and severe sepsis patients. IL6 exhibited the better kinetics for monitoring the effectiveness of antibiotic treatment.",

keywords = "C-reactive protein, Interleukin-6, Procalcitonin, Sepsis, Systemic inflammatory response syndrome",

author = "Jekarl, {Dong Wook} and Lee, {So Young} and Jehoon Lee and Park, {Yeon Joon} and Yonggoo Kim and Park, {Jeong Ho} and Wee, {Jung Hee} and Choi, {Seung Pill}",

note = "Funding Information: The authors thank Yeon-Ju An, Jung soon Kim, and Mi-Ran Lee for excellent technical assistance. This study was supported by the Yeouido St. Mary's Hospital Clinical Research Center, The Catholic University of Korea . The authors also thank the center for assistance. Part of the IL-6 diagnostic kit was a generous gift from Sa-Gang Lab. Tech. Co., Ltd.",

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doi = "10.1016/j.diagmicrobio.2012.12.011",

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AU - Jekarl, Dong Wook

AU - Lee, So Young

AU - Lee, Jehoon

AU - Park, Yeon Joon

AU - Kim, Yonggoo

AU - Park, Jeong Ho

AU - Wee, Jung Hee

AU - Choi, Seung Pill

N1 - Funding Information: The authors thank Yeon-Ju An, Jung soon Kim, and Mi-Ran Lee for excellent technical assistance. This study was supported by the Yeouido St. Mary's Hospital Clinical Research Center, The Catholic University of Korea . The authors also thank the center for assistance. Part of the IL-6 diagnostic kit was a generous gift from Sa-Gang Lab. Tech. Co., Ltd.

PY - 2013/4

Y1 - 2013/4

N2 - The diagnosis and prognosis of sepsis after antimicrobial therapy among systemic inflammatory response syndrome (SIRS) patients were evaluated with the biomarkers procalcitonin (PCT), interleukin-6 (IL-6), C-reactive protein (CRP), erythrocyte sedimentation rate, and white blood cell counts.Among 177 consecutive SIRS patients, 78 exhibited sepsis, with Escherichia coli (23.1%) being the most common pathogen. PCT showed the best diagnostic performance, with 74.4% and 93.7% sensitivity and 86.7% and 75.2% specificity among sepsis and severe sepsis/septic shock patients, respectively. PCT, IL-6, and CRP levels were significantly increased in nonsurvivors compared to survivors. Serial measurements at 0, 12, 24, 48, 72, and 96 h showed that IL-6 showed better kinetics in the survivor group and was decreased in more than 86% of survivors by the second day.PCT can support the diagnosis of bacterial infection, especially in septic shock and severe sepsis patients. IL6 exhibited the better kinetics for monitoring the effectiveness of antibiotic treatment.

AB - The diagnosis and prognosis of sepsis after antimicrobial therapy among systemic inflammatory response syndrome (SIRS) patients were evaluated with the biomarkers procalcitonin (PCT), interleukin-6 (IL-6), C-reactive protein (CRP), erythrocyte sedimentation rate, and white blood cell counts.Among 177 consecutive SIRS patients, 78 exhibited sepsis, with Escherichia coli (23.1%) being the most common pathogen. PCT showed the best diagnostic performance, with 74.4% and 93.7% sensitivity and 86.7% and 75.2% specificity among sepsis and severe sepsis/septic shock patients, respectively. PCT, IL-6, and CRP levels were significantly increased in nonsurvivors compared to survivors. Serial measurements at 0, 12, 24, 48, 72, and 96 h showed that IL-6 showed better kinetics in the survivor group and was decreased in more than 86% of survivors by the second day.PCT can support the diagnosis of bacterial infection, especially in septic shock and severe sepsis patients. IL6 exhibited the better kinetics for monitoring the effectiveness of antibiotic treatment.

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KW - Interleukin-6

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KW - Sepsis

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Procalcitonin as a diagnostic marker and IL-6 as a prognostic marker for sepsis

Abstract

Bibliographical note

Keywords

UN SDGs

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