Prognostic Impact of the HFA-PEFF Score in Patients with Acute Myocardial Infarction and an Intermediate to High HFA-PEFF Score

Kwan Yong Lee, Byung Hee Hwang, Chan Jun Kim, Young Kyoung Sa, Young Choi, Jin Jin Kim, Eun Ho Choo, Sungmin Lim, Ik Jun Choi, Mahn Won Park, Gyu Chul Oh, In Ho Yang, Ki Dong Yoo, Wook Sung Chung, Kiyuk Chang

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Abstract

This study aimed to investigate the efficacy of the HFA-PEFF score in predicting the long-term risks in patients with acute myocardial infarction (AMI) and an HFA-PEFF score ≥ 2. The subjects were divided according to their HFA-PEFF score into intermediate (2–3 points) and high (4–6 points) score groups. The primary outcome was all-cause mortality. Of 1018 patients with AMI and an HFA-PEFF score of ≥2, 712 (69.9%) and 306 (30.1%) were classified into the intermediate and high score groups, respectively. Over a median follow-up of 4.8 (3.2, 6.5) years, 114 (16.0%) and 87 (28.4%) patients died in each group. Multivariate Cox regression identified a high HFA-PEFF score as an independent predictor of all-cause mortality [hazard ratio (HR): 1.53, 95% CI: 1.15–2.04, p = 0.004]. The predictive accuracies for the discrimination and reclassification were significantly improved (C-index 0.750 [95% CI 0.712–0.789]; p = 0.049 and NRI 0.330 [95% CI 0.180–0.479]; p < 0.001) upon the addition of a high HFA-PEFF score to clinical risk factors. The model was better at predicting combined events of all-cause mortality and heart failure readmission (C-index 0.754 [95% CI 0.716–0.791]; p = 0.033, NRI 0.372 [95% CI 0.227–0.518]; p < 0.001). In the AMI cohort, the HFA-PEFF score can effectively predict the prognosis of patients with an HFA-PEFF score of ≥2.

Original languageEnglish
Article number4589
JournalJournal of Clinical Medicine
Volume11
Issue number15
DOIs
StatePublished - Aug 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors.

Keywords

  • heart failure
  • heart failure with preserved ejection fraction
  • myocardial infarction
  • percutaneous coronary intervention

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