Prognostic significance of amplification of the c-MYC gene in surgically treated stage IB-IIB cervical cancer

Tae Jung Kim, Ahwon Lee, Sung Jong Lee, Won Chul Lee, Kyo Young Lee, Chang Suk Kang

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1 Scopus citations

Abstract

Background: Mutations of c-MYC have been described in cervical cancer. However, association between c-MYC gene status and its prognostic significance have not been clarified. Methods: Tissue microarray sections from 144 patients with stage IB-IIB cervical cancer treated by radical hysterectomy were analyzed by fluorescence in situ hybridization using a region-specific probe for c-MYC and a centromere-specific probe for chromosome 8. Results: Seventy five percent (108/144) of c-MYC gain and 6.9% (10/144) of c-MYC gene amplification were observed. c-MYC gene alteration was more frequently observed in squamous cell carcinoma than adenocarcinoma or adenosquamous carcinoma and were associated with low Ki67 labeling index (p=0.013). c-MYC amplification was not associated with clinicopathologic parameters except absence of bcl2 expression (p=0.048). Survival analysis revealed that patients with c-MYC amplification were significantly associated with higher risk of disease recurrence (p=0.007) and cancer related death (p=0.020). However, c-MYC gain was not associated with unfavorable outcome. Multivariate analysis proved c-MYC amplification as independent prognostic factors of shorter disease free survival and cancer-related death (p=0.028 and p=0.025, respectively). Conclusions: c-MYC amplification, not gain, is an independent prognostic marker for shorter disease free and cancer specific survival in cervical cancer treated by radical hysterectomy.

Original languageEnglish
Pages (from-to)596-603
Number of pages8
JournalKorean Journal of Pathology
Volume45
Issue number6
DOIs
StatePublished - Dec 2011

Keywords

  • Hysterectomy
  • In situ hybridization, fluorescence
  • MYC
  • Prognosis
  • Uterine cervical neoplasms

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