Abstract
The World Health Organization has identified Alzheimer’s disease (AD), the leading cause of dementia globally, as a public health priority. However, the complex multifactorial pathology of AD means that its etiology remains incompletely understood. Despite being recognized a century ago, incomplete knowledge has hindered the development of effective treatments for AD. Recent scientific advancements, particularly in induced pluripotent stem cell (iPSC) technology, show great promise in elucidating the fundamental mechanisms of AD. iPSCs play a dual role in regenerating damaged cells for therapeutic purposes and creating disease models to understand AD pathology and aid in drug screening. Nevertheless, as an emerging field, iPSC technology requires further technological advancement to develop effective AD treatments in the future. Thus, this review summarizes recent advances in stem cell therapies, specifically iPSCs, aimed at understanding AD pathology and developing treatments.
| Original language | English |
|---|---|
| Pages (from-to) | 157-170 |
| Number of pages | 14 |
| Journal | Histology and Histopathology |
| Volume | 40 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2025 |
Bibliographical note
Publisher Copyright:© The Author(s) 2024.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Alzheimer’s disease
- Disease modeling
- Drug screening
- Induced pluripotent stem cell
- Neurodegenerative disease
- Regenerative cell therapy
- Stem cells
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