Protective effect of peroxisome proliferator activated receptor gamma agonists on diabetic and non-diabetic renal diseases

Byung Ha Chung; Sun Woo Lim; Kyung Ohk Ahn; Akira Sugawara; Sadayoshi Ito; Bum Soon Choi; Yong Soo Kim; Byung Kee Bang; Chul Woo Yang

doi:10.1111/j.1440-1797.2005.00456.x

Protective effect of peroxisome proliferator activated receptor gamma agonists on diabetic and non-diabetic renal diseases

Byung Ha Chung
, Sun Woo Lim
, Kyung Ohk Ahn
, Akira Sugawara
, Sadayoshi Ito
, Bum Soon Choi
, Yong Soo Kim
, Byung Kee Bang
, Chul Woo Yang

The Catholic University of Korea
Tohoku University

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Peroxisome proliferator activated receptor gamma (PPARγ) agonist has not only antidiabetic effect but also a protective effect against various types of injury of the kidney. The protective effects of PPARγ agonists are observed in diabetic nephropathy and non-diabetic renal diseases such as 5/6 ablation model of renal failure, experimental glomerulonephritis, ischemia-reperfusion injury, hypertensive nephropathy and cyclosporin-induced renal injury. The mechanism of renoprotection by PPARγ agonist is multifactorial. Anti-fibrotic and anti-inflammatory effects, suppression of renin-angiotensin system, vascular protective effect and antiapoptotic effect were proposed.

Original language	English
Pages (from-to)	S40-S43
Journal	Nephrology
Volume	10
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1111/j.1440-1797.2005.00456.x
State	Published - Oct 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Diabetic nephropathy
Kidney disease
Peroxisome proliferator activated receptor-gamma
Rosiglitazone

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10.1111/j.1440-1797.2005.00456.x

Cite this

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title = "Protective effect of peroxisome proliferator activated receptor gamma agonists on diabetic and non-diabetic renal diseases",

abstract = "Peroxisome proliferator activated receptor gamma (PPARγ) agonist has not only antidiabetic effect but also a protective effect against various types of injury of the kidney. The protective effects of PPARγ agonists are observed in diabetic nephropathy and non-diabetic renal diseases such as 5/6 ablation model of renal failure, experimental glomerulonephritis, ischemia-reperfusion injury, hypertensive nephropathy and cyclosporin-induced renal injury. The mechanism of renoprotection by PPARγ agonist is multifactorial. Anti-fibrotic and anti-inflammatory effects, suppression of renin-angiotensin system, vascular protective effect and antiapoptotic effect were proposed.",

keywords = "Diabetic nephropathy, Kidney disease, Peroxisome proliferator activated receptor-gamma, Rosiglitazone",

author = "Chung, \{Byung Ha\} and Lim, \{Sun Woo\} and Ahn, \{Kyung Ohk\} and Akira Sugawara and Sadayoshi Ito and Choi, \{Bum Soon\} and Kim, \{Yong Soo\} and Bang, \{Byung Kee\} and Yang, \{Chul Woo\}",

year = "2005",

month = oct,

doi = "10.1111/j.1440-1797.2005.00456.x",

language = "English",

volume = "10",

pages = "S40--S43",

journal = "Nephrology",

issn = "1320-5358",

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}

TY - JOUR

T1 - Protective effect of peroxisome proliferator activated receptor gamma agonists on diabetic and non-diabetic renal diseases

AU - Chung, Byung Ha

AU - Lim, Sun Woo

AU - Ahn, Kyung Ohk

AU - Sugawara, Akira

AU - Ito, Sadayoshi

AU - Choi, Bum Soon

AU - Kim, Yong Soo

AU - Bang, Byung Kee

AU - Yang, Chul Woo

PY - 2005/10

Y1 - 2005/10

N2 - Peroxisome proliferator activated receptor gamma (PPARγ) agonist has not only antidiabetic effect but also a protective effect against various types of injury of the kidney. The protective effects of PPARγ agonists are observed in diabetic nephropathy and non-diabetic renal diseases such as 5/6 ablation model of renal failure, experimental glomerulonephritis, ischemia-reperfusion injury, hypertensive nephropathy and cyclosporin-induced renal injury. The mechanism of renoprotection by PPARγ agonist is multifactorial. Anti-fibrotic and anti-inflammatory effects, suppression of renin-angiotensin system, vascular protective effect and antiapoptotic effect were proposed.

AB - Peroxisome proliferator activated receptor gamma (PPARγ) agonist has not only antidiabetic effect but also a protective effect against various types of injury of the kidney. The protective effects of PPARγ agonists are observed in diabetic nephropathy and non-diabetic renal diseases such as 5/6 ablation model of renal failure, experimental glomerulonephritis, ischemia-reperfusion injury, hypertensive nephropathy and cyclosporin-induced renal injury. The mechanism of renoprotection by PPARγ agonist is multifactorial. Anti-fibrotic and anti-inflammatory effects, suppression of renin-angiotensin system, vascular protective effect and antiapoptotic effect were proposed.

KW - Diabetic nephropathy

KW - Kidney disease

KW - Peroxisome proliferator activated receptor-gamma

KW - Rosiglitazone

UR - https://www.scopus.com/pages/publications/28544436514

U2 - 10.1111/j.1440-1797.2005.00456.x

DO - 10.1111/j.1440-1797.2005.00456.x

M3 - Article

C2 - 16174287

AN - SCOPUS:28544436514

SN - 1320-5358

VL - 10

SP - S40-S43

JO - Nephrology

JF - Nephrology

IS - SUPPL. 2

ER -

Protective effect of peroxisome proliferator activated receptor gamma agonists on diabetic and non-diabetic renal diseases

Abstract

UN SDGs

Keywords

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