Abstract
Background: It has been suggested that maintaining the efficient organization of the brain’s functional connectivity (FC) supports neuroflexibility under neurogenerative stress. This study examined psychological resilience-related FC in 112 older adults with mild cognitive impairment (MCI). Methods: Using a resting-state functional magnetic resonance imaging (fMRI) approach, we investigated reorganization of the orbitofrontal gyrus (OFG)/amygdala (AMG)/ hippocampus (HP)/parahippocampal gyrus (PHG) FC according to the different levels of resilience scale. Results: Compared with the low resilient group, the high resilient group had greater connectivity strengths between the left inferior OFG and right superior OFG (P < 0.05, Bonferroni corrected), between the right inferior OFG and left PHG (P < 0.05, Bonferroni corrected), and between the right middle OFG and left PHG (false discovery rate < 0.05). Conclusion: Psychological resilience may be associated with enhancement of the orbitofrontal network in the elderly with MCI.
| Original language | English |
|---|---|
| Article number | 615 |
| Journal | Frontiers in Psychiatry |
| Volume | 10 |
| Issue number | AUG |
| DOIs | |
| State | Published - 2019 |
Bibliographical note
Publisher Copyright:© 2019, Son, Park, Choi, Roh, Kim, Sin, Kim, Lim and Hong.
Keywords
- Elderly
- Functional connectivity
- Orbitofrontal cortex
- Resilience
- fMRI
