Ramipril treatment suppresses islet fibrosis in Otsuka Long-Evans Tokushima fatty rats

Seung Hyun Ko; Hyuk Sang Kwon; Sung Rae Kim; Sung Dae Moon; Yu Bae Ahn; Ki Ho Song; Hyun Sik Son; Bong Yun Cha; Kwang Woo Lee; Ho Young Son; Sung Koo Kang; Chung Gyu Park; In Kyu Lee; Kun Ho Yoon

doi:10.1016/j.bbrc.2004.02.023

Ramipril treatment suppresses islet fibrosis in Otsuka Long-Evans Tokushima fatty rats

Seung Hyun Ko
, Hyuk Sang Kwon
, Sung Rae Kim
, Sung Dae Moon
, Yu Bae Ahn
, Ki Ho Song
, Hyun Sik Son
, Bong Yun Cha
, Kwang Woo Lee
, Ho Young Son
, Sung Koo Kang
, Chung Gyu Park
, In Kyu Lee
, Kun Ho Yoon

The Catholic University of Korea
Seoul National University
Keimyung University

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

We evaluated whether ramipril, one of long-acting ACEIs, has a direct effect on pancreas islets in animal model of type 2 diabetes. OLETF rats were treated with ramipril for 24 weeks. We assessed the body weight, glucose tolerance, and the amount of islet fibrosis. RT-PCR and Western blot analysis of transforming growth factor-β with its downstream signals were performed from the pancreas. Ramipril treatment remarkably reduced weight gain and the area under the curve of glucose. Islet fibrosis and the expression of TGF-β with its downstream signal molecules were significantly reduced in the pancreas of ramipril-treated group than in control and paired-feeding group. These beneficial effects of ramipril might be related to the downregulation of TGF-β and its downstream signals in OLETF rats. To our knowledge, this is the first report suggesting the potential effect of ramipril on the prevention of islet destruction by fibrosis in the animal model of type 2 diabetes mellitus.

Original language	English
Pages (from-to)	114-122
Number of pages	9
Journal	Biochemical and Biophysical Research Communications
Volume	316
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2004.02.023
State	Published - 26 Mar 2004

Bibliographical note

Funding Information:
This work was supported by grants from the Korea Science and Engineering Foundation (R01-2001-000-00114-0) and Biochallenger Program grant of NRDP, National Research and Development Program, and MOST, The Ministry of Science and Technology (Project No. M10310060000-03B4606-00000). The authors specially thank Oak-Ki Hong, Sun-Hee Suh, Sung-Yoon Jeon, and Myung-Mi Kim for their technical assistance. We thank Otsuka Pharmaceutical Company and Aventis Pharmaceutical for the donation of rats and ramipril.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Islet fibrosis
Otsuka Long-Evans Tokushima fatty rat
Ramipril
Transforming growth factor-β
α-Smooth muscle actin

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10.1016/j.bbrc.2004.02.023

Cite this

Ko, S. H., Kwon, H. S., Kim, S. R., Moon, S. D., Ahn, Y. B., Song, K. H., Son, H. S., Cha, B. Y., Lee, K. W., Son, H. Y., Kang, S. K., Park, C. G., Lee, I. K., & Yoon, K. H. (2004). Ramipril treatment suppresses islet fibrosis in Otsuka Long-Evans Tokushima fatty rats. Biochemical and Biophysical Research Communications, 316(1), 114-122. https://doi.org/10.1016/j.bbrc.2004.02.023

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title = "Ramipril treatment suppresses islet fibrosis in Otsuka Long-Evans Tokushima fatty rats",

abstract = "We evaluated whether ramipril, one of long-acting ACEIs, has a direct effect on pancreas islets in animal model of type 2 diabetes. OLETF rats were treated with ramipril for 24 weeks. We assessed the body weight, glucose tolerance, and the amount of islet fibrosis. RT-PCR and Western blot analysis of transforming growth factor-β with its downstream signals were performed from the pancreas. Ramipril treatment remarkably reduced weight gain and the area under the curve of glucose. Islet fibrosis and the expression of TGF-β with its downstream signal molecules were significantly reduced in the pancreas of ramipril-treated group than in control and paired-feeding group. These beneficial effects of ramipril might be related to the downregulation of TGF-β and its downstream signals in OLETF rats. To our knowledge, this is the first report suggesting the potential effect of ramipril on the prevention of islet destruction by fibrosis in the animal model of type 2 diabetes mellitus.",

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author = "Ko, \{Seung Hyun\} and Kwon, \{Hyuk Sang\} and Kim, \{Sung Rae\} and Moon, \{Sung Dae\} and Ahn, \{Yu Bae\} and Song, \{Ki Ho\} and Son, \{Hyun Sik\} and Cha, \{Bong Yun\} and Lee, \{Kwang Woo\} and Son, \{Ho Young\} and Kang, \{Sung Koo\} and Park, \{Chung Gyu\} and Lee, \{In Kyu\} and Yoon, \{Kun Ho\}",

note = "Funding Information: This work was supported by grants from the Korea Science and Engineering Foundation (R01-2001-000-00114-0) and Biochallenger Program grant of NRDP, National Research and Development Program, and MOST, The Ministry of Science and Technology (Project No. M10310060000-03B4606-00000). The authors specially thank Oak-Ki Hong, Sun-Hee Suh, Sung-Yoon Jeon, and Myung-Mi Kim for their technical assistance. We thank Otsuka Pharmaceutical Company and Aventis Pharmaceutical for the donation of rats and ramipril.",

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AU - Ko, Seung Hyun

AU - Kwon, Hyuk Sang

AU - Kim, Sung Rae

AU - Moon, Sung Dae

AU - Ahn, Yu Bae

AU - Song, Ki Ho

AU - Son, Hyun Sik

AU - Cha, Bong Yun

AU - Lee, Kwang Woo

AU - Son, Ho Young

AU - Kang, Sung Koo

AU - Park, Chung Gyu

AU - Lee, In Kyu

AU - Yoon, Kun Ho

N1 - Funding Information: This work was supported by grants from the Korea Science and Engineering Foundation (R01-2001-000-00114-0) and Biochallenger Program grant of NRDP, National Research and Development Program, and MOST, The Ministry of Science and Technology (Project No. M10310060000-03B4606-00000). The authors specially thank Oak-Ki Hong, Sun-Hee Suh, Sung-Yoon Jeon, and Myung-Mi Kim for their technical assistance. We thank Otsuka Pharmaceutical Company and Aventis Pharmaceutical for the donation of rats and ramipril.

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N2 - We evaluated whether ramipril, one of long-acting ACEIs, has a direct effect on pancreas islets in animal model of type 2 diabetes. OLETF rats were treated with ramipril for 24 weeks. We assessed the body weight, glucose tolerance, and the amount of islet fibrosis. RT-PCR and Western blot analysis of transforming growth factor-β with its downstream signals were performed from the pancreas. Ramipril treatment remarkably reduced weight gain and the area under the curve of glucose. Islet fibrosis and the expression of TGF-β with its downstream signal molecules were significantly reduced in the pancreas of ramipril-treated group than in control and paired-feeding group. These beneficial effects of ramipril might be related to the downregulation of TGF-β and its downstream signals in OLETF rats. To our knowledge, this is the first report suggesting the potential effect of ramipril on the prevention of islet destruction by fibrosis in the animal model of type 2 diabetes mellitus.

AB - We evaluated whether ramipril, one of long-acting ACEIs, has a direct effect on pancreas islets in animal model of type 2 diabetes. OLETF rats were treated with ramipril for 24 weeks. We assessed the body weight, glucose tolerance, and the amount of islet fibrosis. RT-PCR and Western blot analysis of transforming growth factor-β with its downstream signals were performed from the pancreas. Ramipril treatment remarkably reduced weight gain and the area under the curve of glucose. Islet fibrosis and the expression of TGF-β with its downstream signal molecules were significantly reduced in the pancreas of ramipril-treated group than in control and paired-feeding group. These beneficial effects of ramipril might be related to the downregulation of TGF-β and its downstream signals in OLETF rats. To our knowledge, this is the first report suggesting the potential effect of ramipril on the prevention of islet destruction by fibrosis in the animal model of type 2 diabetes mellitus.

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KW - Transforming growth factor-β

KW - α-Smooth muscle actin

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JF - Biochemical and Biophysical Research Communications

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ER -

Ramipril treatment suppresses islet fibrosis in Otsuka Long-Evans Tokushima fatty rats

Abstract

Bibliographical note

UN SDGs

Keywords

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