Abstract
The prime goal of vaccination is to induce an effective memory T-cell response, because memory T cells have a pivotal role in adaptive immunity. When a specific pathogen is encountered after vaccination, memory immune cells induce an adaptive immune response against that pathogen, which is faster and stronger than a primary immune response. Therefore, the development of a successful vaccine requires a T-cell response of adequate magnitude. Although many vaccines effectively induce protective immune responses against specific pathogens, some vaccines require boosting due to inadequate generation of memory immune cells. It was reported recently that rapamycin, which is used as an immunosuppressive drug for organ transplantation, stimulates the production of memory CD8 T cells. This means that rapamycin or related drugs could be used to enhance the efficacy of many types of vaccines.
| Original language | English |
|---|---|
| Pages (from-to) | 1535-1539 |
| Number of pages | 5 |
| Journal | Expert Review of Vaccines |
| Volume | 8 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2009 |
Bibliographical note
Funding Information:Jae-Hwan Nam is supported by grants from the Gyeonggi Regional Research Center of the Catholic University of Korea, Korea Rural Development Administration and the Ministry of Knowledge Economy and Korea Industrial Technology Foundation through the Human Resource Training Project for Strategic Technology. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Keywords
- Memory CD8 T cells
- mTOR
- Rapamycin
- Vaccine
