Rapidly-progressive glomerulonephritis in a patient with Behcet's disease: Successful treatment with intravenous cyclophosphamide

Sung Dong Kim; Sang Hyon Kim; Hae Rim Kim; Chong Hyeon Yoon; Sang Heon Lee; Sung Hwan Park; Ho Youn Kim

doi:10.1007/s00296-005-0621-y

Rapidly-progressive glomerulonephritis in a patient with Behcet's disease: Successful treatment with intravenous cyclophosphamide

Sung Dong Kim, Sang Hyon Kim, Hae Rim Kim, Chong Hyeon Yoon, Sang Heon Lee, Sung Hwan Park, Ho Youn Kim

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We report a case of rapidly-progressive glomerulonephritis complicating Behcet's disease (BD). A 44-year-old male has suffered from recurrent oral ulcers and retinal vasculitis developed 2 years ago. He complained of abdominal pain and papulopustular skin lesions. Multiple ulcers were seen on the colon on colonoscopy. Routine renal work-up revealed heavy proteinuria and hematuria. Renal biopsy demonstrated crescentic glomerulonephritis. Most symptoms improved after steroid therapy, except for urinary abnormalities. At this point, intravenous monthly cyclophosphamide pulse therapy was undergone. After the sixth pulse therapy, proteinuria and hematuria were dramatically improved and renal function was well preserved.

Original language	English
Pages (from-to)	540-542
Number of pages	3
Journal	Rheumatology International
Volume	25
Issue number	7
DOIs	https://doi.org/10.1007/s00296-005-0621-y
State	Published - Sep 2005

Bibliographical note

Funding Information:
Acknowledgement This work was supported by grant (R11-2002-098-07003-0) from Korea Science& Engineering Foundation through the RhRC(Rheumatism Research Center) at Catholic University, and financial sopport from Konkuk University.

Keywords

Behcet's disease
Cyclophosphamide
Rapidly-progressive glomerulonephritis

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10.1007/s00296-005-0621-y

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title = "Rapidly-progressive glomerulonephritis in a patient with Behcet's disease: Successful treatment with intravenous cyclophosphamide",

abstract = "We report a case of rapidly-progressive glomerulonephritis complicating Behcet's disease (BD). A 44-year-old male has suffered from recurrent oral ulcers and retinal vasculitis developed 2 years ago. He complained of abdominal pain and papulopustular skin lesions. Multiple ulcers were seen on the colon on colonoscopy. Routine renal work-up revealed heavy proteinuria and hematuria. Renal biopsy demonstrated crescentic glomerulonephritis. Most symptoms improved after steroid therapy, except for urinary abnormalities. At this point, intravenous monthly cyclophosphamide pulse therapy was undergone. After the sixth pulse therapy, proteinuria and hematuria were dramatically improved and renal function was well preserved.",

keywords = "Behcet's disease, Cyclophosphamide, Rapidly-progressive glomerulonephritis",

author = "Kim, {Sung Dong} and Kim, {Sang Hyon} and Kim, {Hae Rim} and Yoon, {Chong Hyeon} and Lee, {Sang Heon} and Park, {Sung Hwan} and Kim, {Ho Youn}",

note = "Funding Information: Acknowledgement This work was supported by grant (R11-2002-098-07003-0) from Korea Science& Engineering Foundation through the RhRC(Rheumatism Research Center) at Catholic University, and financial sopport from Konkuk University.",

year = "2005",

month = sep,

doi = "10.1007/s00296-005-0621-y",

language = "English",

volume = "25",

pages = "540--542",

journal = "Rheumatology International",

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TY - JOUR

T1 - Rapidly-progressive glomerulonephritis in a patient with Behcet's disease

T2 - Successful treatment with intravenous cyclophosphamide

AU - Kim, Sung Dong

AU - Kim, Sang Hyon

AU - Kim, Hae Rim

AU - Yoon, Chong Hyeon

AU - Lee, Sang Heon

AU - Park, Sung Hwan

AU - Kim, Ho Youn

N1 - Funding Information: Acknowledgement This work was supported by grant (R11-2002-098-07003-0) from Korea Science& Engineering Foundation through the RhRC(Rheumatism Research Center) at Catholic University, and financial sopport from Konkuk University.

PY - 2005/9

Y1 - 2005/9

N2 - We report a case of rapidly-progressive glomerulonephritis complicating Behcet's disease (BD). A 44-year-old male has suffered from recurrent oral ulcers and retinal vasculitis developed 2 years ago. He complained of abdominal pain and papulopustular skin lesions. Multiple ulcers were seen on the colon on colonoscopy. Routine renal work-up revealed heavy proteinuria and hematuria. Renal biopsy demonstrated crescentic glomerulonephritis. Most symptoms improved after steroid therapy, except for urinary abnormalities. At this point, intravenous monthly cyclophosphamide pulse therapy was undergone. After the sixth pulse therapy, proteinuria and hematuria were dramatically improved and renal function was well preserved.

AB - We report a case of rapidly-progressive glomerulonephritis complicating Behcet's disease (BD). A 44-year-old male has suffered from recurrent oral ulcers and retinal vasculitis developed 2 years ago. He complained of abdominal pain and papulopustular skin lesions. Multiple ulcers were seen on the colon on colonoscopy. Routine renal work-up revealed heavy proteinuria and hematuria. Renal biopsy demonstrated crescentic glomerulonephritis. Most symptoms improved after steroid therapy, except for urinary abnormalities. At this point, intravenous monthly cyclophosphamide pulse therapy was undergone. After the sixth pulse therapy, proteinuria and hematuria were dramatically improved and renal function was well preserved.

KW - Behcet's disease

KW - Cyclophosphamide

KW - Rapidly-progressive glomerulonephritis

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U2 - 10.1007/s00296-005-0621-y

DO - 10.1007/s00296-005-0621-y

M3 - Article

C2 - 15986085

AN - SCOPUS:25144446360

SN - 0172-8172

VL - 25

SP - 540

EP - 542

JO - Rheumatology International

JF - Rheumatology International

IS - 7

ER -

Rapidly-progressive glomerulonephritis in a patient with Behcet's disease: Successful treatment with intravenous cyclophosphamide

Abstract

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Keywords

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