Recent advances in ph-or/and photo-responsive nanovehicles

Yuseon Shin; Patihul Husni; Kioh Kang; Dayoon Lee; Sehwa Lee; Eunseong Lee; Yuseok Youn; Kyungtaek Oh

doi:10.3390/pharmaceutics13050725

Recent advances in ph-or/and photo-responsive nanovehicles

Yuseon Shin
, Patihul Husni
, Kioh Kang
, Dayoon Lee
, Sehwa Lee
, Eunseong Lee
, Yuseok Youn
, Kyungtaek Oh

Department of Biomedical-Chemical Engineering

Chung-Ang University
Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.

Original language	English
Article number	725
Journal	Pharmaceutics
Volume	13
Issue number	5
DOIs	https://doi.org/10.3390/pharmaceutics13050725
State	Published - 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Acid-labile bond
Chemotherapy
Light
Nanovehicles
PH
Photodynamic
Photothermal
Protonation
Stimuli

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10.3390/pharmaceutics13050725

Cite this

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title = "Recent advances in ph-or/and photo-responsive nanovehicles",

abstract = "The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.",

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AU - Shin, Yuseon

AU - Husni, Patihul

AU - Kang, Kioh

AU - Lee, Dayoon

AU - Lee, Sehwa

AU - Lee, Eunseong

AU - Youn, Yuseok

AU - Oh, Kyungtaek

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AB - The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.

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KW - Chemotherapy

KW - Light

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KW - Photodynamic

KW - Photothermal

KW - Protonation

KW - Stimuli

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ER -

Recent advances in ph-or/and photo-responsive nanovehicles

Abstract

Bibliographical note

Keywords

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