Abstract
The purpose of this study was to investigate regional cerebral blood flow (rCBF) changes using 1110 MBq of Tc-99m ECD SPECT in alcohol-related dementia (ARD) patients. Twenty-five patients with ARD and 22 healthy control subjects were included in the study. Mini-Mental Status Examination was applied to the patients and controls. The ARD patients showed drastically reduced rCBF in the frontal cortices, basal ganglia, and thalami. The results indicate that ARD is associated with hypoperfusion in both cortical and subcortical regions. These findings support previous studies suggesting the association with both cortical and subcortical neuropathology in ARD patients.
| Original language | English |
|---|---|
| Pages (from-to) | 2100-2111 |
| Number of pages | 12 |
| Journal | International Journal of Neuroscience |
| Volume | 119 |
| Issue number | 11 |
| DOIs | |
| State | Published - 2009 |
Bibliographical note
Funding Information:Received 20 July 2009. 1Yong-An Chung and Sam-Wook Choi equally contributed to this work as joint first authors. This work was supported by a grant of the Korea Health 21 R&D Progect. Ministry of Health & Welfare, R.O.K(03-PJ10-PG13-GD01-0002) and a Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MOST) (No. R01-2007-000-21094-0). Address correspondence to Dai-Jin Kim, Department of Psychiatry, Holy Family Hospital, College of Medicine, The Catholic University of Korea, 2 Sosa-Dong Buchon-City, Kunggi-do, 420-717, Korea. E-mail: [email protected]
Keywords
- Alcohol dependence
- Alcohol-related dementia
- Cerebral blood flow
- Cortical and subcortical regions
- Hypoperfusion
- SPECT