Abstract
Acyl-CoA synthetase 4 (ACS4) is an arachidonate-preferring enzyme abundant in steroidogenic tissues. We demonstrate that ACS4 expression in steroidogenic tissues in vivo is induced by adrenocorticotropic hormone (ACTH) and suppressed by glucocorticoid. ACTH also induced ACS4 protein but not its mRNA in Y1 adrenocortical tumor cells, whereas both ACS4 mRNA and protein were increased by dibutyryl cAMP (db-cAMP) and forskolin. Furthermore, the levels of ACS4 mRNA and protein in Y1 cells were induced by arachidonate. These data suggest that ACS4 expression in steroidogenic cells is regulated in coordination with induced steroidogenesis and arachidonate released by cholesterol ester hydrolase. (C) 2000 Academic Press.
| Original language | English |
|---|---|
| Pages (from-to) | 741-745 |
| Number of pages | 5 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 274 |
| Issue number | 3 |
| DOIs | |
| State | Published - 11 Aug 2000 |
Bibliographical note
Funding Information:We thank Dr. Ian Gleadall for critical reading of the manuscript. This work was supported by the Japan Society for the Promotion of Science Grant RFTF97L00803.
Keywords
- ACTH
- Acyl-CoA synthetase
- Arachidonate
- Steroidogenesis
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