Regulation of systemic energy homeostasis by serotonin in adipose tissues

Chang Myung Oh; Jun Namkung; Younghoon Go; Ko Eun Shong; Kyuho Kim; Hyeongseok Kim; Bo Yoon Park; Ho Won Lee; Yong Hyun Jeon; Junghan Song; Minho Shong; Vijay K. Yadav; Gerard Karsenty; Shingo Kajimura; In Kyu Lee; Sangkyu Park; Hail Kim

doi:10.1038/ncomms7794

Regulation of systemic energy homeostasis by serotonin in adipose tissues

Chang Myung Oh, Jun Namkung, Younghoon Go, Ko Eun Shong, Kyuho Kim, Hyeongseok Kim, Bo Yoon Park, Ho Won Lee, Yong Hyun Jeon, Junghan Song, Minho Shong, Vijay K. Yadav, Gerard Karsenty, Shingo Kajimura, In Kyu Lee, Sangkyu Park, Hail Kim

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

201 Scopus citations

Abstract

Central serotonin (5-HT) is an anorexigenic neurotransmitter in the brain. However, accumulating evidence suggests peripheral 5-HT may affect organismal energy homeostasis. Here we show 5-HT regulates white and brown adipose tissue function. Pharmacological inhibition of 5-HT synthesis leads to inhibition of lipogenesis in epididymal white adipose tissue (WAT), induction of browning in inguinal WAT and activation of adaptive thermogenesis in brown adipose tissue (BAT). Mice with inducible Tph1 KO in adipose tissues exhibit a similar phenotype as mice in which 5-HT synthesis is inhibited pharmacologically, suggesting 5-HT has localized effects on adipose tissues. In addition, Htr3a KO mice exhibit increased energy expenditure and reduced weight gain when fed a high-fat diet. Treatment with an Htr2a antagonist reduces lipid accumulation in 3T3-L1 adipocytes. These data suggest important roles for adipocyte-derived 5-HT in controlling energy homeostasis.

Original language	English
Article number	6794
Journal	Nature Communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms7794
State	Published - 13 Apr 2015

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title = "Regulation of systemic energy homeostasis by serotonin in adipose tissues",

abstract = "Central serotonin (5-HT) is an anorexigenic neurotransmitter in the brain. However, accumulating evidence suggests peripheral 5-HT may affect organismal energy homeostasis. Here we show 5-HT regulates white and brown adipose tissue function. Pharmacological inhibition of 5-HT synthesis leads to inhibition of lipogenesis in epididymal white adipose tissue (WAT), induction of browning in inguinal WAT and activation of adaptive thermogenesis in brown adipose tissue (BAT). Mice with inducible Tph1 KO in adipose tissues exhibit a similar phenotype as mice in which 5-HT synthesis is inhibited pharmacologically, suggesting 5-HT has localized effects on adipose tissues. In addition, Htr3a KO mice exhibit increased energy expenditure and reduced weight gain when fed a high-fat diet. Treatment with an Htr2a antagonist reduces lipid accumulation in 3T3-L1 adipocytes. These data suggest important roles for adipocyte-derived 5-HT in controlling energy homeostasis.",

author = "Oh, {Chang Myung} and Jun Namkung and Younghoon Go and Shong, {Ko Eun} and Kyuho Kim and Hyeongseok Kim and Park, {Bo Yoon} and Lee, {Ho Won} and Jeon, {Yong Hyun} and Junghan Song and Minho Shong and Yadav, {Vijay K.} and Gerard Karsenty and Shingo Kajimura and Lee, {In Kyu} and Sangkyu Park and Hail Kim",

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AU - Kim, Hyeongseok

AU - Park, Bo Yoon

AU - Lee, Ho Won

AU - Jeon, Yong Hyun

AU - Song, Junghan

AU - Shong, Minho

AU - Yadav, Vijay K.

AU - Karsenty, Gerard

AU - Kajimura, Shingo

AU - Lee, In Kyu

AU - Park, Sangkyu

AU - Kim, Hail

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Regulation of systemic energy homeostasis by serotonin in adipose tissues

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