Repression of antibiotic downregulator WblA by AdpA in Streptomyces coelicolor

Han Na Lee; Jin Su Kim; Pil Kim; Heung Shick Lee; Eung Soo Kim

doi:10.1128/AEM.00546-13

Repression of antibiotic downregulator WblA by AdpA in Streptomyces coelicolor

Han Na Lee
, Jin Su Kim
, Pil Kim
, Heung Shick Lee
, Eung Soo Kim

Dept. of Biotechnology

Inha University
Korea University

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The upstream region of antibiotic downregulatory wblA in Streptomyces coelicolor wasfound to contain AdpA binding motifs. A key morphological regulator, AdpA was shown to specifically bind these motifs by electrophoretic mobility shift assay. An adpA disruption mutant exhibited increased wblA transcription, suggesting that AdpA negatively regulates wblA transcription in S. coelicolor.

Original language	English
Pages (from-to)	4159-4163
Number of pages	5
Journal	Applied and Environmental Microbiology
Volume	79
Issue number	13
DOIs	https://doi.org/10.1128/AEM.00546-13
State	Published - Jul 2013

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title = "Repression of antibiotic downregulator WblA by AdpA in Streptomyces coelicolor",

abstract = "The upstream region of antibiotic downregulatory wblA in Streptomyces coelicolor wasfound to contain AdpA binding motifs. A key morphological regulator, AdpA was shown to specifically bind these motifs by electrophoretic mobility shift assay. An adpA disruption mutant exhibited increased wblA transcription, suggesting that AdpA negatively regulates wblA transcription in S. coelicolor.",

author = "Lee, \{Han Na\} and Kim, \{Jin Su\} and Pil Kim and Lee, \{Heung Shick\} and Kim, \{Eung Soo\}",

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AU - Lee, Han Na

AU - Kim, Jin Su

AU - Kim, Pil

AU - Lee, Heung Shick

AU - Kim, Eung Soo

PY - 2013/7

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AB - The upstream region of antibiotic downregulatory wblA in Streptomyces coelicolor wasfound to contain AdpA binding motifs. A key morphological regulator, AdpA was shown to specifically bind these motifs by electrophoretic mobility shift assay. An adpA disruption mutant exhibited increased wblA transcription, suggesting that AdpA negatively regulates wblA transcription in S. coelicolor.

UR - https://www.scopus.com/pages/publications/84879814656

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DO - 10.1128/AEM.00546-13

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AN - SCOPUS:84879814656

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EP - 4163

JO - Applied and Environmental Microbiology

JF - Applied and Environmental Microbiology

IS - 13

ER -

Repression of antibiotic downregulator WblA by AdpA in Streptomyces coelicolor

Abstract

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