Reversible posterior leukoencephalopathy syndrome in a patient with multiple system atrophy: A possible association with oral midodrine treatment

Joong Seok Kim; Kwang Soo Lee; Sung Chul Lim; Jae Young Ahn; In Uk Song; Yeong In Kim; Bum Soo Kim; Hee Tae Kim

doi:10.1002/mds.21461

Reversible posterior leukoencephalopathy syndrome in a patient with multiple system atrophy: A possible association with oral midodrine treatment

Joong Seok Kim
, Kwang Soo Lee
, Sung Chul Lim
, Jae Young Ahn
, In Uk Song
, Yeong In Kim
, Bum Soo Kim
, Hee Tae Kim

The Catholic University of Korea
Catholic Univ. of Korea Coll. Med.
Hanyang University

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We describe a 51-year-old man with a 3-year history of multiple system atrophy, who developed a reversible posterior leukoencephalopathy syndrome (RPLS) after receiving prescription midodrine for therapeutic treatment of orthostatic hypotension. Typical reversible magnetic resonance imaging findings, following treatment with midodrine, suggested a possible relationship between midodrine treatment, supine hypertension, and RPLS, although a cause-and-effect relationship cannot be confirmed.

Original language	English
Pages (from-to)	1043-1046
Number of pages	4
Journal	Movement Disorders
Volume	22
Issue number	7
DOIs	https://doi.org/10.1002/mds.21461
State	Published - 15 May 2007

Keywords

Midodrine
Multiple system atrophy
Orthostatic hypotension
Reversible posterior leukoencephalopathy syndrome

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10.1002/mds.21461

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title = "Reversible posterior leukoencephalopathy syndrome in a patient with multiple system atrophy: A possible association with oral midodrine treatment",

abstract = "We describe a 51-year-old man with a 3-year history of multiple system atrophy, who developed a reversible posterior leukoencephalopathy syndrome (RPLS) after receiving prescription midodrine for therapeutic treatment of orthostatic hypotension. Typical reversible magnetic resonance imaging findings, following treatment with midodrine, suggested a possible relationship between midodrine treatment, supine hypertension, and RPLS, although a cause-and-effect relationship cannot be confirmed.",

keywords = "Midodrine, Multiple system atrophy, Orthostatic hypotension, Reversible posterior leukoencephalopathy syndrome",

author = "Kim, \{Joong Seok\} and Lee, \{Kwang Soo\} and Lim, \{Sung Chul\} and Ahn, \{Jae Young\} and Song, \{In Uk\} and Kim, \{Yeong In\} and Kim, \{Bum Soo\} and Kim, \{Hee Tae\}",

year = "2007",

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T1 - Reversible posterior leukoencephalopathy syndrome in a patient with multiple system atrophy

T2 - A possible association with oral midodrine treatment

AU - Kim, Joong Seok

AU - Lee, Kwang Soo

AU - Lim, Sung Chul

AU - Ahn, Jae Young

AU - Song, In Uk

AU - Kim, Yeong In

AU - Kim, Bum Soo

AU - Kim, Hee Tae

PY - 2007/5/15

Y1 - 2007/5/15

N2 - We describe a 51-year-old man with a 3-year history of multiple system atrophy, who developed a reversible posterior leukoencephalopathy syndrome (RPLS) after receiving prescription midodrine for therapeutic treatment of orthostatic hypotension. Typical reversible magnetic resonance imaging findings, following treatment with midodrine, suggested a possible relationship between midodrine treatment, supine hypertension, and RPLS, although a cause-and-effect relationship cannot be confirmed.

AB - We describe a 51-year-old man with a 3-year history of multiple system atrophy, who developed a reversible posterior leukoencephalopathy syndrome (RPLS) after receiving prescription midodrine for therapeutic treatment of orthostatic hypotension. Typical reversible magnetic resonance imaging findings, following treatment with midodrine, suggested a possible relationship between midodrine treatment, supine hypertension, and RPLS, although a cause-and-effect relationship cannot be confirmed.

KW - Midodrine

KW - Multiple system atrophy

KW - Orthostatic hypotension

KW - Reversible posterior leukoencephalopathy syndrome

UR - https://www.scopus.com/pages/publications/34347249931

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DO - 10.1002/mds.21461

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SP - 1043

EP - 1046

JO - Movement Disorders

JF - Movement Disorders

IS - 7

ER -

Reversible posterior leukoencephalopathy syndrome in a patient with multiple system atrophy: A possible association with oral midodrine treatment

Abstract

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