Seroprevalence of hepatitis A virus in pediatric patients with hematologic malignancies after chemotherapy and hematopoietic cell transplantation

Ja Un Moon; A. Luem Han; Eui Soo Lee; Seong koo Kim; Seung Beom Han; Jae Wook Lee; Nack Gyun Chung; Bin Cho; Dae Chul Jeong; Jin Han Kang

doi:10.3947/ic.2019.51.2.183

Seroprevalence of hepatitis A virus in pediatric patients with hematologic malignancies after chemotherapy and hematopoietic cell transplantation

Ja Un Moon
, A. Luem Han
, Eui Soo Lee
, Seong koo Kim
, Seung Beom Han
, Jae Wook Lee
, Nack Gyun Chung
, Bin Cho
, Dae Chul Jeong
, Jin Han Kang

Department of Pediatrics

The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

This retrospective study was performed to determine the seroprevalence of hepatitis A virus (HAV) in children and adolescents with hematologic malignancies after the completion of chemotherapy and hematopoietic cell transplantation (HCT). Of 97 enrolled patients, 60 (61.9%) were seropositive for HAV. The seroprevalences in patients undergoing chemotherapy and HCT were 60.3% (41/68) and 65.5% (19/29), respectively (P = 0.628). No significant factors associated with seropositivity for HAV after chemotherapy and HCT were identified. Anti-HAV tests and HAV re-vaccinations can be considered in children and adolescents with underlying hematologic malignancies after chemotherapy and HCT based on the anti-HAV results.

Original language	English
Pages (from-to)	183-187
Number of pages	5
Journal	Infection and Chemotherapy
Volume	51
Issue number	2
DOIs	https://doi.org/10.3947/ic.2019.51.2.183
State	Published - 2019

Bibliographical note

Publisher Copyright:
Copyright © 2019 by The Korean Society of Infectious Diseases and Korean Society for Antimicrobial Therapy.

Keywords

Chemotherapy
Child
Hepatitis A virus
Seroprevalence
Stem cell transplantation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3947/ic.2019.51.2.183

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title = "Seroprevalence of hepatitis A virus in pediatric patients with hematologic malignancies after chemotherapy and hematopoietic cell transplantation",

abstract = "This retrospective study was performed to determine the seroprevalence of hepatitis A virus (HAV) in children and adolescents with hematologic malignancies after the completion of chemotherapy and hematopoietic cell transplantation (HCT). Of 97 enrolled patients, 60 (61.9\%) were seropositive for HAV. The seroprevalences in patients undergoing chemotherapy and HCT were 60.3\% (41/68) and 65.5\% (19/29), respectively (P = 0.628). No significant factors associated with seropositivity for HAV after chemotherapy and HCT were identified. Anti-HAV tests and HAV re-vaccinations can be considered in children and adolescents with underlying hematologic malignancies after chemotherapy and HCT based on the anti-HAV results.",

keywords = "Chemotherapy, Child, Hepatitis A virus, Seroprevalence, Stem cell transplantation",

author = "Moon, \{Ja Un\} and Han, \{A. Luem\} and Lee, \{Eui Soo\} and Kim, \{Seong koo\} and Han, \{Seung Beom\} and Lee, \{Jae Wook\} and Chung, \{Nack Gyun\} and Bin Cho and Jeong, \{Dae Chul\} and Kang, \{Jin Han\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2019 by The Korean Society of Infectious Diseases and Korean Society for Antimicrobial Therapy.",

year = "2019",

doi = "10.3947/ic.2019.51.2.183",

language = "English",

volume = "51",

pages = "183--187",

journal = "Infection and Chemotherapy",

issn = "2093-2340",

publisher = "Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, Korean Society for AIDS, Korean Society of Pediatric Infectious Diseases",

number = "2",

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TY - JOUR

T1 - Seroprevalence of hepatitis A virus in pediatric patients with hematologic malignancies after chemotherapy and hematopoietic cell transplantation

AU - Moon, Ja Un

AU - Han, A. Luem

AU - Lee, Eui Soo

AU - Kim, Seong koo

AU - Han, Seung Beom

AU - Lee, Jae Wook

AU - Chung, Nack Gyun

AU - Cho, Bin

AU - Jeong, Dae Chul

AU - Kang, Jin Han

PY - 2019

Y1 - 2019

N2 - This retrospective study was performed to determine the seroprevalence of hepatitis A virus (HAV) in children and adolescents with hematologic malignancies after the completion of chemotherapy and hematopoietic cell transplantation (HCT). Of 97 enrolled patients, 60 (61.9%) were seropositive for HAV. The seroprevalences in patients undergoing chemotherapy and HCT were 60.3% (41/68) and 65.5% (19/29), respectively (P = 0.628). No significant factors associated with seropositivity for HAV after chemotherapy and HCT were identified. Anti-HAV tests and HAV re-vaccinations can be considered in children and adolescents with underlying hematologic malignancies after chemotherapy and HCT based on the anti-HAV results.

AB - This retrospective study was performed to determine the seroprevalence of hepatitis A virus (HAV) in children and adolescents with hematologic malignancies after the completion of chemotherapy and hematopoietic cell transplantation (HCT). Of 97 enrolled patients, 60 (61.9%) were seropositive for HAV. The seroprevalences in patients undergoing chemotherapy and HCT were 60.3% (41/68) and 65.5% (19/29), respectively (P = 0.628). No significant factors associated with seropositivity for HAV after chemotherapy and HCT were identified. Anti-HAV tests and HAV re-vaccinations can be considered in children and adolescents with underlying hematologic malignancies after chemotherapy and HCT based on the anti-HAV results.

KW - Chemotherapy

KW - Child

KW - Hepatitis A virus

KW - Seroprevalence

KW - Stem cell transplantation

UR - https://www.scopus.com/pages/publications/85068826717

U2 - 10.3947/ic.2019.51.2.183

DO - 10.3947/ic.2019.51.2.183

M3 - Article

AN - SCOPUS:85068826717

SN - 2093-2340

VL - 51

SP - 183

EP - 187

JO - Infection and Chemotherapy

JF - Infection and Chemotherapy

IS - 2

ER -

Seroprevalence of hepatitis A virus in pediatric patients with hematologic malignancies after chemotherapy and hematopoietic cell transplantation

Abstract

Bibliographical note

Keywords

UN SDGs

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