Serum carboxy-terminal propeptide of type I procollagen (PIP) is a marker of diastolic dysfunction in patients with early type 2 diabetes mellitus

This study was designed to investigate whether the serum concentration of the carboxy-terminal propeptide of procollagen type I (PIP), a marker of myocardial fibrosis, is related to changes of the ventricular filling dynamics in patients with early type 2 diabetes mellitus (T2DM). The T2DM group had lower mitral and tricuspid E/A ratios than the control group. Serum PIP was higher in patients with T2DM than in controls (131.1 ± 45.6 vs. 109.3 ± 32.5 ng/mL, p = 0.039). A-Ar, an estimate of passive diastolic function, was inversely related to serum PIP levels in T2DM (r = - 0.42, p = 0.03). These results show a relation between LV diastolic function and serum PIP levels in early T2DM.