Serum ferritin predicts mortality regardless of inflammatory and nutritional status in patients starting dialysis: A prospective cohort study

Kyoung Sook Park; Geun Woo Ryu; Jong Hyun Jhee; Hyung Woo Kim; Seohyun Park; Sul A. Lee; Young Eun Kwon; Yung Ly Kim; Han Jak Ryu; Mi Jung Lee; Seung Hyeok Han; Tae Hyun Yoo; Yong Lim Kim; Yon Su Kim; Chul Woo Yang; Nam Ho Kim; Shin Wook Kang; Jung Tak Park

doi:10.1159/000438819

Serum ferritin predicts mortality regardless of inflammatory and nutritional status in patients starting dialysis: A prospective cohort study

Kyoung Sook Park
, Geun Woo Ryu
, Jong Hyun Jhee
, Hyung Woo Kim
, Seohyun Park
, Sul A. Lee
, Young Eun Kwon
, Yung Ly Kim
, Han Jak Ryu
, Mi Jung Lee
, Seung Hyeok Han
, Tae Hyun Yoo
, Yong Lim Kim
, Yon Su Kim
, Chul Woo Yang
, Nam Ho Kim
, Shin Wook Kang
, Jung Tak Park

Division of Nephrology

Yonsei University
Kyungpook National University
Seoul National University
Chonnam National University

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background: The impact of serum ferritin on prognosis in patients starting hemodialysis (HD) is not fully elucidated. Methods: A prospective cohort of 946 incident HD patients from 26 dialysis centers in Korea was selected for this study. Patients were divided into tertiles according to natural logarithm (Ln) ferritin concentrations. Results: During a median follow-up of 39 months, 88 (9.3%) patients died. Multivariate Cox proportional hazard analysis demonstrated that Ln ferritin was independently associated with an increase in cardiovascular mortality risk (hazard ratio (HR) 1.604, 95% CI 1.040-2.474, p = 0.033), infection-related mortality risk (HR 1.916, 95% CI 1.056-3.476, p = 0.032), and all-cause mortality risk (HR 1.547, 95% CI 1.156-2.069, p = 0.003). Conclusion: Serum ferritin levels at the time of HD commencement were a significant independent risk factor for mortality regardless of systemic inflammation and nutritional status. Therefore, elevated serum ferritin levels could be an effective indicator for prognosis.

Original language	English
Pages (from-to)	209-217
Number of pages	9
Journal	Blood Purification
Volume	40
Issue number	3
DOIs	https://doi.org/10.1159/000438819
State	Published - 1 Oct 2015

Bibliographical note

Publisher Copyright:
© 2015 S. Karger AG, Basel.

Keywords

Clinical outcome
End-stage renal disease
Ferritin
Hemodialysis

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10.1159/000438819

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Park, K. S., Ryu, G. W., Jhee, J. H., Kim, H. W., Park, S., Lee, S. A., Kwon, Y. E., Kim, Y. L., Ryu, H. J., Lee, M. J., Han, S. H., Yoo, T. H., Kim, Y. L., Kim, Y. S., Yang, C. W., Kim, N. H., Kang, S. W., & Park, J. T. (2015). Serum ferritin predicts mortality regardless of inflammatory and nutritional status in patients starting dialysis: A prospective cohort study. Blood Purification, 40(3), 209-217. https://doi.org/10.1159/000438819

@article{690352b328c94717bd650036ef95ca45,

title = "Serum ferritin predicts mortality regardless of inflammatory and nutritional status in patients starting dialysis: A prospective cohort study",

abstract = "Background: The impact of serum ferritin on prognosis in patients starting hemodialysis (HD) is not fully elucidated. Methods: A prospective cohort of 946 incident HD patients from 26 dialysis centers in Korea was selected for this study. Patients were divided into tertiles according to natural logarithm (Ln) ferritin concentrations. Results: During a median follow-up of 39 months, 88 (9.3\%) patients died. Multivariate Cox proportional hazard analysis demonstrated that Ln ferritin was independently associated with an increase in cardiovascular mortality risk (hazard ratio (HR) 1.604, 95\% CI 1.040-2.474, p = 0.033), infection-related mortality risk (HR 1.916, 95\% CI 1.056-3.476, p = 0.032), and all-cause mortality risk (HR 1.547, 95\% CI 1.156-2.069, p = 0.003). Conclusion: Serum ferritin levels at the time of HD commencement were a significant independent risk factor for mortality regardless of systemic inflammation and nutritional status. Therefore, elevated serum ferritin levels could be an effective indicator for prognosis.",

keywords = "Clinical outcome, End-stage renal disease, Ferritin, Hemodialysis",

author = "Park, \{Kyoung Sook\} and Ryu, \{Geun Woo\} and Jhee, \{Jong Hyun\} and Kim, \{Hyung Woo\} and Seohyun Park and Lee, \{Sul A.\} and Kwon, \{Young Eun\} and Kim, \{Yung Ly\} and Ryu, \{Han Jak\} and Lee, \{Mi Jung\} and Han, \{Seung Hyeok\} and Yoo, \{Tae Hyun\} and Kim, \{Yong Lim\} and Kim, \{Yon Su\} and Yang, \{Chul Woo\} and Kim, \{Nam Ho\} and Kang, \{Shin Wook\} and Park, \{Jung Tak\}",

note = "Publisher Copyright: {\textcopyright} 2015 S. Karger AG, Basel.",

year = "2015",

month = oct,

day = "1",

doi = "10.1159/000438819",

language = "English",

volume = "40",

pages = "209--217",

journal = "Blood Purification",

issn = "0253-5068",

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Park, KS, Ryu, GW, Jhee, JH, Kim, HW, Park, S, Lee, SA, Kwon, YE, Kim, YL, Ryu, HJ, Lee, MJ, Han, SH, Yoo, TH, Kim, YL, Kim, YS, Yang, CW, Kim, NH, Kang, SW & Park, JT 2015, 'Serum ferritin predicts mortality regardless of inflammatory and nutritional status in patients starting dialysis: A prospective cohort study', Blood Purification, vol. 40, no. 3, pp. 209-217. https://doi.org/10.1159/000438819

TY - JOUR

T1 - Serum ferritin predicts mortality regardless of inflammatory and nutritional status in patients starting dialysis

T2 - A prospective cohort study

AU - Park, Kyoung Sook

AU - Ryu, Geun Woo

AU - Jhee, Jong Hyun

AU - Kim, Hyung Woo

AU - Park, Seohyun

AU - Lee, Sul A.

AU - Kwon, Young Eun

AU - Kim, Yung Ly

AU - Ryu, Han Jak

AU - Lee, Mi Jung

AU - Han, Seung Hyeok

AU - Yoo, Tae Hyun

AU - Kim, Yong Lim

AU - Kim, Yon Su

AU - Yang, Chul Woo

AU - Kim, Nam Ho

AU - Kang, Shin Wook

AU - Park, Jung Tak

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Background: The impact of serum ferritin on prognosis in patients starting hemodialysis (HD) is not fully elucidated. Methods: A prospective cohort of 946 incident HD patients from 26 dialysis centers in Korea was selected for this study. Patients were divided into tertiles according to natural logarithm (Ln) ferritin concentrations. Results: During a median follow-up of 39 months, 88 (9.3%) patients died. Multivariate Cox proportional hazard analysis demonstrated that Ln ferritin was independently associated with an increase in cardiovascular mortality risk (hazard ratio (HR) 1.604, 95% CI 1.040-2.474, p = 0.033), infection-related mortality risk (HR 1.916, 95% CI 1.056-3.476, p = 0.032), and all-cause mortality risk (HR 1.547, 95% CI 1.156-2.069, p = 0.003). Conclusion: Serum ferritin levels at the time of HD commencement were a significant independent risk factor for mortality regardless of systemic inflammation and nutritional status. Therefore, elevated serum ferritin levels could be an effective indicator for prognosis.

AB - Background: The impact of serum ferritin on prognosis in patients starting hemodialysis (HD) is not fully elucidated. Methods: A prospective cohort of 946 incident HD patients from 26 dialysis centers in Korea was selected for this study. Patients were divided into tertiles according to natural logarithm (Ln) ferritin concentrations. Results: During a median follow-up of 39 months, 88 (9.3%) patients died. Multivariate Cox proportional hazard analysis demonstrated that Ln ferritin was independently associated with an increase in cardiovascular mortality risk (hazard ratio (HR) 1.604, 95% CI 1.040-2.474, p = 0.033), infection-related mortality risk (HR 1.916, 95% CI 1.056-3.476, p = 0.032), and all-cause mortality risk (HR 1.547, 95% CI 1.156-2.069, p = 0.003). Conclusion: Serum ferritin levels at the time of HD commencement were a significant independent risk factor for mortality regardless of systemic inflammation and nutritional status. Therefore, elevated serum ferritin levels could be an effective indicator for prognosis.

KW - Clinical outcome

KW - End-stage renal disease

KW - Ferritin

KW - Hemodialysis

UR - https://www.scopus.com/pages/publications/84940761625

U2 - 10.1159/000438819

DO - 10.1159/000438819

M3 - Article

C2 - 26329834

AN - SCOPUS:84940761625

SN - 0253-5068

VL - 40

SP - 209

EP - 217

JO - Blood Purification

JF - Blood Purification

IS - 3

ER -

Serum ferritin predicts mortality regardless of inflammatory and nutritional status in patients starting dialysis: A prospective cohort study

Abstract

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Keywords

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