SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma

Seung Min Jeong; Annie Lee; Jaewon Lee; Marcia C. Haigis

doi:10.1074/jbc.M113.525949

SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma

Seung Min Jeong
, Annie Lee
, Jaewon Lee
, Marcia C. Haigis

Department of Biochemistry

Harvard University

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Abstract

Background: Glutamine metabolism is essential for Myc-induced tumors. Results: SIRT4 regulates mitochondrial glutamine metabolism and the growth and survival of Burkitt lymphoma cells independent of Myc. Conclusion: SIRT4 has a tumor-suppressive role in Myc-induced B cell lymphoma. Significance: SIRT4 may be a potential target against Myc-driven and glutamine-dependent tumors.

Original language	English
Pages (from-to)	4135-4144
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	289
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M113.525949
State	Published - 14 Feb 2014

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title = "SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma",

abstract = "Background: Glutamine metabolism is essential for Myc-induced tumors. Results: SIRT4 regulates mitochondrial glutamine metabolism and the growth and survival of Burkitt lymphoma cells independent of Myc. Conclusion: SIRT4 has a tumor-suppressive role in Myc-induced B cell lymphoma. Significance: SIRT4 may be a potential target against Myc-driven and glutamine-dependent tumors.",

author = "Jeong, \{Seung Min\} and Annie Lee and Jaewon Lee and Haigis, \{Marcia C.\}",

year = "2014",

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doi = "10.1074/jbc.M113.525949",

language = "English",

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T1 - SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma

AU - Jeong, Seung Min

AU - Lee, Annie

AU - Lee, Jaewon

AU - Haigis, Marcia C.

PY - 2014/2/14

Y1 - 2014/2/14

N2 - Background: Glutamine metabolism is essential for Myc-induced tumors. Results: SIRT4 regulates mitochondrial glutamine metabolism and the growth and survival of Burkitt lymphoma cells independent of Myc. Conclusion: SIRT4 has a tumor-suppressive role in Myc-induced B cell lymphoma. Significance: SIRT4 may be a potential target against Myc-driven and glutamine-dependent tumors.

AB - Background: Glutamine metabolism is essential for Myc-induced tumors. Results: SIRT4 regulates mitochondrial glutamine metabolism and the growth and survival of Burkitt lymphoma cells independent of Myc. Conclusion: SIRT4 has a tumor-suppressive role in Myc-induced B cell lymphoma. Significance: SIRT4 may be a potential target against Myc-driven and glutamine-dependent tumors.

UR - https://www.scopus.com/pages/publications/84894109588

U2 - 10.1074/jbc.M113.525949

DO - 10.1074/jbc.M113.525949

M3 - Article

C2 - 24368766

AN - SCOPUS:84894109588

SN - 0021-9258

VL - 289

SP - 4135

EP - 4144

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 7

ER -

SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma

Abstract

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