SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues

Sungpil Yoon; Young Su Yi; Sang Soo Kim; Ju Hwa Kim; Won Sang Park; Suk Woo Nam

doi:10.1007/s13277-011-0264-4

SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues

Sungpil Yoon
, Young Su Yi
, Sang Soo Kim
, Ju Hwa Kim
, Won Sang Park
, Suk Woo Nam

Department of Pathology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

In the present study, we investigated mRNA expression patterns of both SOCS5 and SOCS6 in various normal and cancer tissues using a commercially available Cancer Profiling Array. We found that SOCS5 and SOCS6 had similar expression patterns in most cancer and healthy individuals, suggesting that these two genes are transcriptionally co-regulated. Tissue-specific up- or down-regulation of SOCS5 and SOCS6 was observed in several cancer tissues. Most importantly, thyroid gland cancer tissues exhibited large reductions of both SOCS5 and SOCS6 expressions. In addition, mRNA and protein levels of SOCS6 were down-regulated in liver cancer tissues. The results from our study may contribute to understanding SOCS5 and SOCS6 expression regulation in various cancer tissues, and show that these two factors may be used for diagnosing cancer.

Original language	English
Pages (from-to)	215-221
Number of pages	7
Journal	Tumor Biology
Volume	33
Issue number	1
DOIs	https://doi.org/10.1007/s13277-011-0264-4
State	Published - Feb 2012

Keywords

Cancer
Liver
SOCS5
SOCS6
Thyroid grand
Tissue specificity
mRNA levels

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13277-011-0264-4

Cite this

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title = "SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues",

abstract = "In the present study, we investigated mRNA expression patterns of both SOCS5 and SOCS6 in various normal and cancer tissues using a commercially available Cancer Profiling Array. We found that SOCS5 and SOCS6 had similar expression patterns in most cancer and healthy individuals, suggesting that these two genes are transcriptionally co-regulated. Tissue-specific up- or down-regulation of SOCS5 and SOCS6 was observed in several cancer tissues. Most importantly, thyroid gland cancer tissues exhibited large reductions of both SOCS5 and SOCS6 expressions. In addition, mRNA and protein levels of SOCS6 were down-regulated in liver cancer tissues. The results from our study may contribute to understanding SOCS5 and SOCS6 expression regulation in various cancer tissues, and show that these two factors may be used for diagnosing cancer.",

keywords = "Cancer, Liver, SOCS5, SOCS6, Thyroid grand, Tissue specificity, mRNA levels",

author = "Sungpil Yoon and Yi, \{Young Su\} and Kim, \{Sang Soo\} and Kim, \{Ju Hwa\} and Park, \{Won Sang\} and Nam, \{Suk Woo\}",

year = "2012",

month = feb,

doi = "10.1007/s13277-011-0264-4",

language = "English",

volume = "33",

pages = "215--221",

journal = "Tumor Biology",

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TY - JOUR

T1 - SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues

AU - Yoon, Sungpil

AU - Yi, Young Su

AU - Kim, Sang Soo

AU - Kim, Ju Hwa

AU - Park, Won Sang

AU - Nam, Suk Woo

PY - 2012/2

Y1 - 2012/2

N2 - In the present study, we investigated mRNA expression patterns of both SOCS5 and SOCS6 in various normal and cancer tissues using a commercially available Cancer Profiling Array. We found that SOCS5 and SOCS6 had similar expression patterns in most cancer and healthy individuals, suggesting that these two genes are transcriptionally co-regulated. Tissue-specific up- or down-regulation of SOCS5 and SOCS6 was observed in several cancer tissues. Most importantly, thyroid gland cancer tissues exhibited large reductions of both SOCS5 and SOCS6 expressions. In addition, mRNA and protein levels of SOCS6 were down-regulated in liver cancer tissues. The results from our study may contribute to understanding SOCS5 and SOCS6 expression regulation in various cancer tissues, and show that these two factors may be used for diagnosing cancer.

AB - In the present study, we investigated mRNA expression patterns of both SOCS5 and SOCS6 in various normal and cancer tissues using a commercially available Cancer Profiling Array. We found that SOCS5 and SOCS6 had similar expression patterns in most cancer and healthy individuals, suggesting that these two genes are transcriptionally co-regulated. Tissue-specific up- or down-regulation of SOCS5 and SOCS6 was observed in several cancer tissues. Most importantly, thyroid gland cancer tissues exhibited large reductions of both SOCS5 and SOCS6 expressions. In addition, mRNA and protein levels of SOCS6 were down-regulated in liver cancer tissues. The results from our study may contribute to understanding SOCS5 and SOCS6 expression regulation in various cancer tissues, and show that these two factors may be used for diagnosing cancer.

KW - Cancer

KW - Liver

KW - SOCS5

KW - SOCS6

KW - Thyroid grand

KW - Tissue specificity

KW - mRNA levels

UR - https://www.scopus.com/pages/publications/83655167103

U2 - 10.1007/s13277-011-0264-4

DO - 10.1007/s13277-011-0264-4

M3 - Article

C2 - 22081311

AN - SCOPUS:83655167103

SN - 1010-4283

VL - 33

SP - 215

EP - 221

JO - Tumor Biology

JF - Tumor Biology

IS - 1

ER -

SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues

Abstract

Keywords

UN SDGs

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