Somatic mutation of PARK2 tumor suppressor gene is not common in common solid cancers

Eun Mi Je; Nam Jin Yoo; Sug Hyung Lee

doi:10.1007/s12253-012-9591-z

Somatic mutation of PARK2 tumor suppressor gene is not common in common solid cancers

Eun Mi Je
, Nam Jin Yoo
, Sug Hyung Lee

Department of Pathology

The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Recent studies identified that PARK2 gene was a candidate tumor suppressor gene in colorectal cancers and glioblastomas. The aim of this study was identify whether PARK2 somatic mutation is present in other solid tumor as well. In this study, we analyzed the entire coding sequences of human PARK2 gene in gastric, colorectal, breast, lung and prostate carcinoma by single-strand conformation polymorphism (SSCP) and subsequent direct DNA sequencing. We found two missense mutations (p.Ser9Thr and p.Gly450Val) in colon carcinomas (4.3 %), which were not overlapped with the known PARK2 mutations. Our data suggest that somatic mutational events in PARK2 gene may be rare in colorectal, gastric, prostate, breast and lung carcinomas and may not play an important role in the development of these cancers.

Original language	English
Pages (from-to)	393-395
Number of pages	3
Journal	Pathology and Oncology Research
Volume	19
Issue number	3
DOIs	https://doi.org/10.1007/s12253-012-9591-z
State	Published - Jul 2013

Bibliographical note

Funding Information:
Acknowledgements This work was supported by a grant from National Research Foundation of Korea (2012047939).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancers
Mutation
PARK2
Tumor suppressor

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10.1007/s12253-012-9591-z

Cite this

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title = "Somatic mutation of PARK2 tumor suppressor gene is not common in common solid cancers",

abstract = "Recent studies identified that PARK2 gene was a candidate tumor suppressor gene in colorectal cancers and glioblastomas. The aim of this study was identify whether PARK2 somatic mutation is present in other solid tumor as well. In this study, we analyzed the entire coding sequences of human PARK2 gene in gastric, colorectal, breast, lung and prostate carcinoma by single-strand conformation polymorphism (SSCP) and subsequent direct DNA sequencing. We found two missense mutations (p.Ser9Thr and p.Gly450Val) in colon carcinomas (4.3 \%), which were not overlapped with the known PARK2 mutations. Our data suggest that somatic mutational events in PARK2 gene may be rare in colorectal, gastric, prostate, breast and lung carcinomas and may not play an important role in the development of these cancers.",

keywords = "Cancers, Mutation, PARK2, Tumor suppressor",

author = "Je, \{Eun Mi\} and Yoo, \{Nam Jin\} and Lee, \{Sug Hyung\}",

note = "Funding Information: Acknowledgements This work was supported by a grant from National Research Foundation of Korea (2012047939).",

year = "2013",

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doi = "10.1007/s12253-012-9591-z",

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T1 - Somatic mutation of PARK2 tumor suppressor gene is not common in common solid cancers

AU - Je, Eun Mi

AU - Yoo, Nam Jin

AU - Lee, Sug Hyung

N1 - Funding Information: Acknowledgements This work was supported by a grant from National Research Foundation of Korea (2012047939).

PY - 2013/7

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N2 - Recent studies identified that PARK2 gene was a candidate tumor suppressor gene in colorectal cancers and glioblastomas. The aim of this study was identify whether PARK2 somatic mutation is present in other solid tumor as well. In this study, we analyzed the entire coding sequences of human PARK2 gene in gastric, colorectal, breast, lung and prostate carcinoma by single-strand conformation polymorphism (SSCP) and subsequent direct DNA sequencing. We found two missense mutations (p.Ser9Thr and p.Gly450Val) in colon carcinomas (4.3 %), which were not overlapped with the known PARK2 mutations. Our data suggest that somatic mutational events in PARK2 gene may be rare in colorectal, gastric, prostate, breast and lung carcinomas and may not play an important role in the development of these cancers.

AB - Recent studies identified that PARK2 gene was a candidate tumor suppressor gene in colorectal cancers and glioblastomas. The aim of this study was identify whether PARK2 somatic mutation is present in other solid tumor as well. In this study, we analyzed the entire coding sequences of human PARK2 gene in gastric, colorectal, breast, lung and prostate carcinoma by single-strand conformation polymorphism (SSCP) and subsequent direct DNA sequencing. We found two missense mutations (p.Ser9Thr and p.Gly450Val) in colon carcinomas (4.3 %), which were not overlapped with the known PARK2 mutations. Our data suggest that somatic mutational events in PARK2 gene may be rare in colorectal, gastric, prostate, breast and lung carcinomas and may not play an important role in the development of these cancers.

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KW - Mutation

KW - PARK2

KW - Tumor suppressor

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DO - 10.1007/s12253-012-9591-z

M3 - Article

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AN - SCOPUS:84880333593

SN - 1219-4956

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SP - 393

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JO - Pathology and Oncology Research

JF - Pathology and Oncology Research

IS - 3

ER -

Somatic mutation of PARK2 tumor suppressor gene is not common in common solid cancers

Abstract

Bibliographical note

UN SDGs

Keywords

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