Specific hippocampal choline decrease in an animal model of depression

S. T. Hong; C. B. Choi; C. Park; H. Y. Moon; K. S. Hong; C. Cheong; J. H. Chae; Bo Young Choe

doi:10.1259/bjr/25165760

Specific hippocampal choline decrease in an animal model of depression

S. T. Hong
, C. B. Choi
, C. Park
, H. Y. Moon
, K. S. Hong
, C. Cheong
, J. H. Chae
, Bo Young Choe

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

A decreased level of the hippocampal choline signal was found in patients with depression in previous proton magnetic resonance spectroscopy ( ¹H-MRS) studies. The objective of this study is to compare choline levels before and after the forced swimming test (FST), an animal model of depression typically used for assessing antidepressant activity. ¹H-MRS spectra were obtained from both the left and right hippocampus. After the FST, rats showed a significant decrease of the choline/creatine (Cho/Cr, p=0.037) and choline/N-acetylaspartate (Cho/NAA, p=0.048) ratios in the left hippocampus, but not in the right hippocampus. This finding was analogous to results from patients with depression. It suggests that decreased Cho/Cr and Cho/NAA ratios in the left hippocampal regions might be considered to be biomarkers in rats with depression.

Original language	English
Pages (from-to)	549-553
Number of pages	5
Journal	British Journal of Radiology
Volume	82
Issue number	979
DOIs	https://doi.org/10.1259/bjr/25165760
State	Published - Jul 2009

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title = "Specific hippocampal choline decrease in an animal model of depression",

abstract = "A decreased level of the hippocampal choline signal was found in patients with depression in previous proton magnetic resonance spectroscopy ( 1H-MRS) studies. The objective of this study is to compare choline levels before and after the forced swimming test (FST), an animal model of depression typically used for assessing antidepressant activity. 1H-MRS spectra were obtained from both the left and right hippocampus. After the FST, rats showed a significant decrease of the choline/creatine (Cho/Cr, p=0.037) and choline/N-acetylaspartate (Cho/NAA, p=0.048) ratios in the left hippocampus, but not in the right hippocampus. This finding was analogous to results from patients with depression. It suggests that decreased Cho/Cr and Cho/NAA ratios in the left hippocampal regions might be considered to be biomarkers in rats with depression.",

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T1 - Specific hippocampal choline decrease in an animal model of depression

AU - Hong, S. T.

AU - Choi, C. B.

AU - Park, C.

AU - Moon, H. Y.

AU - Hong, K. S.

AU - Cheong, C.

AU - Chae, J. H.

AU - Choe, Bo Young

PY - 2009/7

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AB - A decreased level of the hippocampal choline signal was found in patients with depression in previous proton magnetic resonance spectroscopy ( 1H-MRS) studies. The objective of this study is to compare choline levels before and after the forced swimming test (FST), an animal model of depression typically used for assessing antidepressant activity. 1H-MRS spectra were obtained from both the left and right hippocampus. After the FST, rats showed a significant decrease of the choline/creatine (Cho/Cr, p=0.037) and choline/N-acetylaspartate (Cho/NAA, p=0.048) ratios in the left hippocampus, but not in the right hippocampus. This finding was analogous to results from patients with depression. It suggests that decreased Cho/Cr and Cho/NAA ratios in the left hippocampal regions might be considered to be biomarkers in rats with depression.

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VL - 82

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JO - British Journal of Radiology

JF - British Journal of Radiology

IS - 979

ER -

Specific hippocampal choline decrease in an animal model of depression

Abstract

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