Stem cell-loaded adhesive immiscible liquid for regeneration of myocardial infarction

Tae Yoon Park; Jeong min Oh; Jung Sun Cho; Sung Bo Sim; Jongho Lee; Hyung Joon Cha

doi:10.1016/j.jconrel.2020.02.047

Stem cell-loaded adhesive immiscible liquid for regeneration of myocardial infarction

Tae Yoon Park, Jeong min Oh, Jung Sun Cho, Sung Bo Sim, Jongho Lee, Hyung Joon Cha

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Myocardial infarction (MI) causes serious loss of cardiac muscle and dysfunction. To restore MI, exogenous stem cells should be efficiently delivered. However, due to severe physical and physiological cardiac environment, recent strategies have faced challenges, including low cell persistence, low integration, and delayed therapeutic effects. Herein, we proposed mesenchymal stem cell (MSC) therapeutic platform using adhesive protein-based immiscible condensed liquid system (APICLS) derived from bioengineered mussel adhesive protein (MAP). With high encapsulation efficiency and survival rate of encapsulated MSCs, APICLS was successfully grafted by intramyocardial injection and distributed throughout the scarred myocardium. Its underwater adhesiveness and biocompatibility fostered integration with damaged tissue, resulting in high cell persistence and maximized paracrine effects. Bioactive molecules released from APICLS with MSCs induced angiogenesis and cardioprotection, delayed cardiac remodeling, reduced fibrosis, and recovered contractive force. Thus, our proposed strategy represents an innovative approach for recovering infarcted cardiac tissues with damaged structural and contractive function.

Original language	English
Pages (from-to)	602-615
Number of pages	14
Journal	Journal of Controlled Release
Volume	321
DOIs	https://doi.org/10.1016/j.jconrel.2020.02.047
State	Published - 10 May 2020

Bibliographical note

Funding Information:
Financial support was provided by the Marine Biomaterials Research Center grant from Marine Biotechnology Program of the Korea Institute of Marine Science & Technology Promotion funded by the Ministry of Oceans and Fisheries , Korea.

Funding Information:
Financial support was provided by the Marine Biomaterials Research Center grant from Marine Biotechnology Program of the Korea Institute of Marine Science & Technology Promotion funded by the Ministry of Oceans and Fisheries, Korea.

Publisher Copyright:
© 2020

Keywords

Cell retention
Mesenchymal stem cell therapy
Mussel adhesive protein
Myocardial infarction
Paracrine effect

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10.1016/j.jconrel.2020.02.047

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title = "Stem cell-loaded adhesive immiscible liquid for regeneration of myocardial infarction",

abstract = "Myocardial infarction (MI) causes serious loss of cardiac muscle and dysfunction. To restore MI, exogenous stem cells should be efficiently delivered. However, due to severe physical and physiological cardiac environment, recent strategies have faced challenges, including low cell persistence, low integration, and delayed therapeutic effects. Herein, we proposed mesenchymal stem cell (MSC) therapeutic platform using adhesive protein-based immiscible condensed liquid system (APICLS) derived from bioengineered mussel adhesive protein (MAP). With high encapsulation efficiency and survival rate of encapsulated MSCs, APICLS was successfully grafted by intramyocardial injection and distributed throughout the scarred myocardium. Its underwater adhesiveness and biocompatibility fostered integration with damaged tissue, resulting in high cell persistence and maximized paracrine effects. Bioactive molecules released from APICLS with MSCs induced angiogenesis and cardioprotection, delayed cardiac remodeling, reduced fibrosis, and recovered contractive force. Thus, our proposed strategy represents an innovative approach for recovering infarcted cardiac tissues with damaged structural and contractive function.",

keywords = "Cell retention, Mesenchymal stem cell therapy, Mussel adhesive protein, Myocardial infarction, Paracrine effect",

author = "Park, {Tae Yoon} and Oh, {Jeong min} and Cho, {Jung Sun} and Sim, {Sung Bo} and Jongho Lee and Cha, {Hyung Joon}",

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AU - Oh, Jeong min

AU - Cho, Jung Sun

AU - Sim, Sung Bo

AU - Lee, Jongho

AU - Cha, Hyung Joon

N1 - Funding Information: Financial support was provided by the Marine Biomaterials Research Center grant from Marine Biotechnology Program of the Korea Institute of Marine Science & Technology Promotion funded by the Ministry of Oceans and Fisheries , Korea. Funding Information: Financial support was provided by the Marine Biomaterials Research Center grant from Marine Biotechnology Program of the Korea Institute of Marine Science & Technology Promotion funded by the Ministry of Oceans and Fisheries, Korea. Publisher Copyright: © 2020

PY - 2020/5/10

Y1 - 2020/5/10

N2 - Myocardial infarction (MI) causes serious loss of cardiac muscle and dysfunction. To restore MI, exogenous stem cells should be efficiently delivered. However, due to severe physical and physiological cardiac environment, recent strategies have faced challenges, including low cell persistence, low integration, and delayed therapeutic effects. Herein, we proposed mesenchymal stem cell (MSC) therapeutic platform using adhesive protein-based immiscible condensed liquid system (APICLS) derived from bioengineered mussel adhesive protein (MAP). With high encapsulation efficiency and survival rate of encapsulated MSCs, APICLS was successfully grafted by intramyocardial injection and distributed throughout the scarred myocardium. Its underwater adhesiveness and biocompatibility fostered integration with damaged tissue, resulting in high cell persistence and maximized paracrine effects. Bioactive molecules released from APICLS with MSCs induced angiogenesis and cardioprotection, delayed cardiac remodeling, reduced fibrosis, and recovered contractive force. Thus, our proposed strategy represents an innovative approach for recovering infarcted cardiac tissues with damaged structural and contractive function.

AB - Myocardial infarction (MI) causes serious loss of cardiac muscle and dysfunction. To restore MI, exogenous stem cells should be efficiently delivered. However, due to severe physical and physiological cardiac environment, recent strategies have faced challenges, including low cell persistence, low integration, and delayed therapeutic effects. Herein, we proposed mesenchymal stem cell (MSC) therapeutic platform using adhesive protein-based immiscible condensed liquid system (APICLS) derived from bioengineered mussel adhesive protein (MAP). With high encapsulation efficiency and survival rate of encapsulated MSCs, APICLS was successfully grafted by intramyocardial injection and distributed throughout the scarred myocardium. Its underwater adhesiveness and biocompatibility fostered integration with damaged tissue, resulting in high cell persistence and maximized paracrine effects. Bioactive molecules released from APICLS with MSCs induced angiogenesis and cardioprotection, delayed cardiac remodeling, reduced fibrosis, and recovered contractive force. Thus, our proposed strategy represents an innovative approach for recovering infarcted cardiac tissues with damaged structural and contractive function.

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KW - Paracrine effect

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Stem cell-loaded adhesive immiscible liquid for regeneration of myocardial infarction

Abstract

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Keywords

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