Super pH-sensitive multifunctional polymeric micelle

Eun Seong Lee; Kun Na; You Man Bae

doi:10.1021/nl0479987

Super pH-sensitive multifunctional polymeric micelle

Eun Seong Lee
, Kun Na
, You Man Bae

University of Utah

Research output: Contribution to journal › Article › peer-review

577 Scopus citations

Abstract

To endow enhanced tumor specificity and endosome disruption property on the carrier, a multifunctional polymeric micelle was investigated. The micelle exposes the cell interacting ligand (biotin) on the surface under slightly acidic environmental conditions of various solid tumors and is internalized by biotin receptor-mediated endocytosis in a short time period. The micelle also showed pH-dependent dissociation, causing the enhanced release of doxorubicin from the carrier in early endosomal pH. The dissociated micellar components subsequently disrupt endosomal membrane.

Original language	English
Pages (from-to)	325-329
Number of pages	5
Journal	Nano Letters
Volume	5
Issue number	2
DOIs	https://doi.org/10.1021/nl0479987
State	Published - Feb 2005

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10.1021/nl0479987

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title = "Super pH-sensitive multifunctional polymeric micelle",

abstract = "To endow enhanced tumor specificity and endosome disruption property on the carrier, a multifunctional polymeric micelle was investigated. The micelle exposes the cell interacting ligand (biotin) on the surface under slightly acidic environmental conditions of various solid tumors and is internalized by biotin receptor-mediated endocytosis in a short time period. The micelle also showed pH-dependent dissociation, causing the enhanced release of doxorubicin from the carrier in early endosomal pH. The dissociated micellar components subsequently disrupt endosomal membrane.",

author = "Lee, \{Eun Seong\} and Kun Na and Bae, \{You Man\}",

year = "2005",

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AU - Bae, You Man

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N2 - To endow enhanced tumor specificity and endosome disruption property on the carrier, a multifunctional polymeric micelle was investigated. The micelle exposes the cell interacting ligand (biotin) on the surface under slightly acidic environmental conditions of various solid tumors and is internalized by biotin receptor-mediated endocytosis in a short time period. The micelle also showed pH-dependent dissociation, causing the enhanced release of doxorubicin from the carrier in early endosomal pH. The dissociated micellar components subsequently disrupt endosomal membrane.

AB - To endow enhanced tumor specificity and endosome disruption property on the carrier, a multifunctional polymeric micelle was investigated. The micelle exposes the cell interacting ligand (biotin) on the surface under slightly acidic environmental conditions of various solid tumors and is internalized by biotin receptor-mediated endocytosis in a short time period. The micelle also showed pH-dependent dissociation, causing the enhanced release of doxorubicin from the carrier in early endosomal pH. The dissociated micellar components subsequently disrupt endosomal membrane.

UR - https://www.scopus.com/pages/publications/14644433029

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DO - 10.1021/nl0479987

M3 - Article

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SN - 1530-6984

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SP - 325

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JO - Nano Letters

JF - Nano Letters

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ER -

Super pH-sensitive multifunctional polymeric micelle

Abstract

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