Surface charge switching nanoparticles for magnetic resonance imaging

Dong Jin Lee; Young Taik Oh; Eun Seong Lee

doi:10.1016/j.ijpharm.2014.05.029

Surface charge switching nanoparticles for magnetic resonance imaging

Dong Jin Lee
, Young Taik Oh
, Eun Seong Lee

Department of Biomedical-Chemical Engineering

The Catholic University of Korea
Yonsei University

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

In this study, polypeptide-based nanoparticles [constituted using poly(l-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid tumors. These nanoparticles exhibited a significantly increased in vitro cellular uptake and high accumulation in the acidic tumor site in vivo. Consequently, Fe ₃O₄-loaded nanoparticles enabled high contrast magnetic resonance (MR) imaging of the tumor in vivo.

Original language	English
Pages (from-to)	127-134
Number of pages	8
Journal	International Journal of Pharmaceutics
Volume	471
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ijpharm.2014.05.029
State	Published - 25 Aug 2014

Bibliographical note

Funding Information:
This work was financially supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare (No. A111291 ), and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( NRF-2013R1A1A2010074 ), Republic of Korea.

Keywords

Magnetic resonance imaging (MRI)
Surface charge switching nanoparticle
pH-Responsive

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10.1016/j.ijpharm.2014.05.029

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title = "Surface charge switching nanoparticles for magnetic resonance imaging",

abstract = "In this study, polypeptide-based nanoparticles [constituted using poly(l-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid tumors. These nanoparticles exhibited a significantly increased in vitro cellular uptake and high accumulation in the acidic tumor site in vivo. Consequently, Fe 3O4-loaded nanoparticles enabled high contrast magnetic resonance (MR) imaging of the tumor in vivo.",

keywords = "Magnetic resonance imaging (MRI), Surface charge switching nanoparticle, pH-Responsive",

author = "Lee, \{Dong Jin\} and Oh, \{Young Taik\} and Lee, \{Eun Seong\}",

note = "Funding Information: This work was financially supported by a grant of the Korean Health Technology R\&D Project, Ministry of Health \& Welfare (No. A111291 ), and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( NRF-2013R1A1A2010074 ), Republic of Korea. ",

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doi = "10.1016/j.ijpharm.2014.05.029",

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T1 - Surface charge switching nanoparticles for magnetic resonance imaging

AU - Lee, Dong Jin

AU - Oh, Young Taik

AU - Lee, Eun Seong

N1 - Funding Information: This work was financially supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare (No. A111291 ), and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( NRF-2013R1A1A2010074 ), Republic of Korea.

PY - 2014/8/25

Y1 - 2014/8/25

N2 - In this study, polypeptide-based nanoparticles [constituted using poly(l-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid tumors. These nanoparticles exhibited a significantly increased in vitro cellular uptake and high accumulation in the acidic tumor site in vivo. Consequently, Fe 3O4-loaded nanoparticles enabled high contrast magnetic resonance (MR) imaging of the tumor in vivo.

AB - In this study, polypeptide-based nanoparticles [constituted using poly(l-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid tumors. These nanoparticles exhibited a significantly increased in vitro cellular uptake and high accumulation in the acidic tumor site in vivo. Consequently, Fe 3O4-loaded nanoparticles enabled high contrast magnetic resonance (MR) imaging of the tumor in vivo.

KW - Magnetic resonance imaging (MRI)

KW - Surface charge switching nanoparticle

KW - pH-Responsive

UR - https://www.scopus.com/pages/publications/84901839142

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DO - 10.1016/j.ijpharm.2014.05.029

M3 - Article

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AN - SCOPUS:84901839142

SN - 0378-5173

VL - 471

SP - 127

EP - 134

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

Surface charge switching nanoparticles for magnetic resonance imaging

Abstract

Bibliographical note

Keywords

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