Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation

Sang Min Lee; De Hao Tsai; Vincent A. Hackley; Martin W. Brechbiel; Robert F. Cook

doi:10.1039/c3nr00333g

Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation

Sang Min Lee
, De Hao Tsai
, Vincent A. Hackley
, Martin W. Brechbiel
, Robert F. Cook

National Institute of Standards and Technology
National Institutes of Health

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

We report a prototype approach to formulate gold nanoparticle-based X-ray absorbing agents through surface-engineering of a cisplatin pharmacophore with modified polyacrylate. The resulting agents exhibit both chemo-therapeutic potency to cancer cells and Auger-mediated secondary electron emission, showing great potential to improve the therapeutic efficacy of chemo-radiation.

Original language	English
Pages (from-to)	5252-5256
Number of pages	5
Journal	Nanoscale
Volume	5
Issue number	12
DOIs	https://doi.org/10.1039/c3nr00333g
State	Published - 21 Jun 2013

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10.1039/c3nr00333g

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title = "Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation",

abstract = "We report a prototype approach to formulate gold nanoparticle-based X-ray absorbing agents through surface-engineering of a cisplatin pharmacophore with modified polyacrylate. The resulting agents exhibit both chemo-therapeutic potency to cancer cells and Auger-mediated secondary electron emission, showing great potential to improve the therapeutic efficacy of chemo-radiation.",

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AU - Lee, Sang Min

AU - Tsai, De Hao

AU - Hackley, Vincent A.

AU - Brechbiel, Martin W.

AU - Cook, Robert F.

PY - 2013/6/21

Y1 - 2013/6/21

N2 - We report a prototype approach to formulate gold nanoparticle-based X-ray absorbing agents through surface-engineering of a cisplatin pharmacophore with modified polyacrylate. The resulting agents exhibit both chemo-therapeutic potency to cancer cells and Auger-mediated secondary electron emission, showing great potential to improve the therapeutic efficacy of chemo-radiation.

AB - We report a prototype approach to formulate gold nanoparticle-based X-ray absorbing agents through surface-engineering of a cisplatin pharmacophore with modified polyacrylate. The resulting agents exhibit both chemo-therapeutic potency to cancer cells and Auger-mediated secondary electron emission, showing great potential to improve the therapeutic efficacy of chemo-radiation.

UR - https://www.scopus.com/pages/publications/84878712011

U2 - 10.1039/c3nr00333g

DO - 10.1039/c3nr00333g

M3 - Article

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EP - 5256

JO - Nanoscale

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IS - 12

ER -

Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation

Abstract

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