TY - JOUR
T1 - Survival impact of postoperative body mass index in gastric cancer patients undergoing gastrectomy
AU - Lee, Han Hee
AU - Park, Jae Myung
AU - Song, Kyo Young
AU - Choi, Myung Gyu
AU - Park, Cho Hyun
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Background The relationship between preoperative body mass index (BMI) and the survival of postoperative gastric cancer patients is not clear. Furthermore, the survival impact with postoperative BMI is not known, even though weight loss is inevitable after gastrectomy. Methods Patients who underwent gastrectomy for gastric cancer between 2000 and 2008 were included in the study (n = 1909). Patients were divided into three groups based on their BMIs: low (<18.5 kg/m2), normal (18.5-24.9 kg/m2), and high BMI (≥25.0 kg/m2). Patient survival was compared according to BMI at two time points: baseline and 1 year after surgery. Results Regarding BMI 1 year after surgery, overall survival, disease-specific survival, and recurrence-free survival were longer in the high BMI group than the low and normal BMI groups. In a Cox proportional hazards model, adjusting for the patient's age, sex, type of surgery, tumour stage, histology, curative resection, and BMI at baseline, a high BMI 1 year after surgery was associated with lower overall mortality compared to normal BMI (hazard ratio 0.51; 95% confidence interval, 0.26-0.98). However, BMI at baseline was not an independent prognostic factor. Conclusion BMI 1 year after surgery significantly predicted the long-term survival of patients with gastric cancer compared with the preoperative BMI.
AB - Background The relationship between preoperative body mass index (BMI) and the survival of postoperative gastric cancer patients is not clear. Furthermore, the survival impact with postoperative BMI is not known, even though weight loss is inevitable after gastrectomy. Methods Patients who underwent gastrectomy for gastric cancer between 2000 and 2008 were included in the study (n = 1909). Patients were divided into three groups based on their BMIs: low (<18.5 kg/m2), normal (18.5-24.9 kg/m2), and high BMI (≥25.0 kg/m2). Patient survival was compared according to BMI at two time points: baseline and 1 year after surgery. Results Regarding BMI 1 year after surgery, overall survival, disease-specific survival, and recurrence-free survival were longer in the high BMI group than the low and normal BMI groups. In a Cox proportional hazards model, adjusting for the patient's age, sex, type of surgery, tumour stage, histology, curative resection, and BMI at baseline, a high BMI 1 year after surgery was associated with lower overall mortality compared to normal BMI (hazard ratio 0.51; 95% confidence interval, 0.26-0.98). However, BMI at baseline was not an independent prognostic factor. Conclusion BMI 1 year after surgery significantly predicted the long-term survival of patients with gastric cancer compared with the preoperative BMI.
KW - Body mass index
KW - Gastrectomy
KW - Prognosis
KW - Stomach neoplasms
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=84949506306&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2015.10.061
DO - 10.1016/j.ejca.2015.10.061
M3 - Article
C2 - 26686912
AN - SCOPUS:84949506306
SN - 0959-8049
VL - 52
SP - 129
EP - 137
JO - European Journal of Cancer
JF - European Journal of Cancer
ER -
