Synchronous primary gastric mantle cell lymphoma and early gastric carcinoma: A case report

Yosep Chong; John Junghun Shin; Mee Yon Cho; Ying Cui; Ho Young Kim; Kwang Hwa Park

doi:10.1016/j.prp.2007.12.008

Synchronous primary gastric mantle cell lymphoma and early gastric carcinoma: A case report

Yosep Chong, John Junghun Shin, Mee Yon Cho, Ying Cui, Ho Young Kim, Kwang Hwa Park

Department of Hospital Pathology

Yonsei University Mirae Campus

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Mantle cell lymphoma (MCL) commonly invades the gastrointestinal (GI) tract. However, primary GI MCL is rare. We experienced a case of synchronous early gastric cancer (EGC) with primary gastric MCL found as a single early lesion rather than as multiple lymphomatous polyposis. An EGC was found in the cardia of a 64-year-old male on a routine GI endoscopic examination. A specimen obtained by total gastrectomy revealed another slightly elevated lesion in the pylorus. Microscopically, monotonous small- to medium-sized atypical lymphocytes with angulated nuclei formed a mass beneath the gastric mucosa. On immunohistochemical staining, the tumor cells revealed strong positivity for cyclin D1, positivity for both CD20 and bcl-2, and weak positivity for CD5, suggesting MCL. Clinically, there was no lymphoma in any other part of the body. This is the first case of an EGC accompanying a primary gastric MCL. Further investigation of a relationship between MCL and EGC and of factors that may affect GI involvement of MCL is necessary.

Original language	English
Pages (from-to)	407-411
Number of pages	5
Journal	Pathology Research and Practice
Volume	204
Issue number	6
DOIs	https://doi.org/10.1016/j.prp.2007.12.008
State	Published - 2 Jun 2008

Keywords

Early gastric carcinoma
Mantle cell lymphoma
Primary gastric

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10.1016/j.prp.2007.12.008

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title = "Synchronous primary gastric mantle cell lymphoma and early gastric carcinoma: A case report",

abstract = "Mantle cell lymphoma (MCL) commonly invades the gastrointestinal (GI) tract. However, primary GI MCL is rare. We experienced a case of synchronous early gastric cancer (EGC) with primary gastric MCL found as a single early lesion rather than as multiple lymphomatous polyposis. An EGC was found in the cardia of a 64-year-old male on a routine GI endoscopic examination. A specimen obtained by total gastrectomy revealed another slightly elevated lesion in the pylorus. Microscopically, monotonous small- to medium-sized atypical lymphocytes with angulated nuclei formed a mass beneath the gastric mucosa. On immunohistochemical staining, the tumor cells revealed strong positivity for cyclin D1, positivity for both CD20 and bcl-2, and weak positivity for CD5, suggesting MCL. Clinically, there was no lymphoma in any other part of the body. This is the first case of an EGC accompanying a primary gastric MCL. Further investigation of a relationship between MCL and EGC and of factors that may affect GI involvement of MCL is necessary.",

keywords = "Early gastric carcinoma, Mantle cell lymphoma, Primary gastric",

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year = "2008",

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doi = "10.1016/j.prp.2007.12.008",

language = "English",

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T1 - Synchronous primary gastric mantle cell lymphoma and early gastric carcinoma

T2 - A case report

AU - Chong, Yosep

AU - Shin, John Junghun

AU - Cho, Mee Yon

AU - Cui, Ying

AU - Kim, Ho Young

AU - Park, Kwang Hwa

PY - 2008/6/2

Y1 - 2008/6/2

N2 - Mantle cell lymphoma (MCL) commonly invades the gastrointestinal (GI) tract. However, primary GI MCL is rare. We experienced a case of synchronous early gastric cancer (EGC) with primary gastric MCL found as a single early lesion rather than as multiple lymphomatous polyposis. An EGC was found in the cardia of a 64-year-old male on a routine GI endoscopic examination. A specimen obtained by total gastrectomy revealed another slightly elevated lesion in the pylorus. Microscopically, monotonous small- to medium-sized atypical lymphocytes with angulated nuclei formed a mass beneath the gastric mucosa. On immunohistochemical staining, the tumor cells revealed strong positivity for cyclin D1, positivity for both CD20 and bcl-2, and weak positivity for CD5, suggesting MCL. Clinically, there was no lymphoma in any other part of the body. This is the first case of an EGC accompanying a primary gastric MCL. Further investigation of a relationship between MCL and EGC and of factors that may affect GI involvement of MCL is necessary.

AB - Mantle cell lymphoma (MCL) commonly invades the gastrointestinal (GI) tract. However, primary GI MCL is rare. We experienced a case of synchronous early gastric cancer (EGC) with primary gastric MCL found as a single early lesion rather than as multiple lymphomatous polyposis. An EGC was found in the cardia of a 64-year-old male on a routine GI endoscopic examination. A specimen obtained by total gastrectomy revealed another slightly elevated lesion in the pylorus. Microscopically, monotonous small- to medium-sized atypical lymphocytes with angulated nuclei formed a mass beneath the gastric mucosa. On immunohistochemical staining, the tumor cells revealed strong positivity for cyclin D1, positivity for both CD20 and bcl-2, and weak positivity for CD5, suggesting MCL. Clinically, there was no lymphoma in any other part of the body. This is the first case of an EGC accompanying a primary gastric MCL. Further investigation of a relationship between MCL and EGC and of factors that may affect GI involvement of MCL is necessary.

KW - Early gastric carcinoma

KW - Mantle cell lymphoma

KW - Primary gastric

UR - https://www.scopus.com/pages/publications/42749093063

U2 - 10.1016/j.prp.2007.12.008

DO - 10.1016/j.prp.2007.12.008

M3 - Article

C2 - 18282664

AN - SCOPUS:42749093063

SN - 0344-0338

VL - 204

SP - 407

EP - 411

JO - Pathology Research and Practice

JF - Pathology Research and Practice

IS - 6

ER -

Synchronous primary gastric mantle cell lymphoma and early gastric carcinoma: A case report

Abstract

Keywords

UN SDGs

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