Synthesis and Characterizations of Biodegradable Polyurethane Microspheres with Dexamethasone for Drug Delivery

Juri Park; Min Jeong Lee; Guk Young Ahn; Tae Hoon Yun; Inseong Choi; Eun Seong Lee; Hyunsuk Lee; Sung Wook Choi

doi:10.1007/s13233-019-7171-8

Synthesis and Characterizations of Biodegradable Polyurethane Microspheres with Dexamethasone for Drug Delivery

Juri Park
, Min Jeong Lee
, Guk Young Ahn
, Tae Hoon Yun
, Inseong Choi
, Eun Seong Lee
, Hyunsuk Lee
, Sung Wook Choi

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

This manuscript reports on the synthesis of biodegradable polyurethanes (PU) using poly(ε-caprolactone) diol and fabrication of microspheres containing dexamethasone (DEX). Biodegradable PUs with different isocyanate ratios were successfully synthesized using PCL diol as a polyol. The PU with a high isocyanate ratio exhibited a low average molecular weight, high melting point, high Young’s modulus, low tensile strength, low elongation to break, low hydrolytic degradation rate, and fast release profile of DEX. These results can be used to optimize properties so as to be suitable for specific applications. Our next goal is to evaluate the performance of PU microspheres as an injectable cartilage filler through in vitro and in vivo studies. In addition, the biodegradable PUs can be used for tissue-engineered scaffolds using three-dimensional printing. [Figure not available: see fulltext.].

Original language	English
Pages (from-to)	839-842
Number of pages	4
Journal	Macromolecular Research
Volume	27
Issue number	9
DOIs	https://doi.org/10.1007/s13233-019-7171-8
State	Published - 1 Sep 2019

Bibliographical note

Publisher Copyright:
© 2019, The Polymer Society of Korea and Springer.

Keywords

biodegradation
dexamethasone
microsphere
polyurethane

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10.1007/s13233-019-7171-8

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title = "Synthesis and Characterizations of Biodegradable Polyurethane Microspheres with Dexamethasone for Drug Delivery",

abstract = "This manuscript reports on the synthesis of biodegradable polyurethanes (PU) using poly(ε-caprolactone) diol and fabrication of microspheres containing dexamethasone (DEX). Biodegradable PUs with different isocyanate ratios were successfully synthesized using PCL diol as a polyol. The PU with a high isocyanate ratio exhibited a low average molecular weight, high melting point, high Young{\textquoteright}s modulus, low tensile strength, low elongation to break, low hydrolytic degradation rate, and fast release profile of DEX. These results can be used to optimize properties so as to be suitable for specific applications. Our next goal is to evaluate the performance of PU microspheres as an injectable cartilage filler through in vitro and in vivo studies. In addition, the biodegradable PUs can be used for tissue-engineered scaffolds using three-dimensional printing. [Figure not available: see fulltext.].",

keywords = "biodegradation, dexamethasone, microsphere, polyurethane",

author = "Juri Park and Lee, \{Min Jeong\} and Ahn, \{Guk Young\} and Yun, \{Tae Hoon\} and Inseong Choi and Lee, \{Eun Seong\} and Hyunsuk Lee and Choi, \{Sung Wook\}",

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year = "2019",

month = sep,

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doi = "10.1007/s13233-019-7171-8",

language = "English",

volume = "27",

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journal = "Macromolecular Research",

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T1 - Synthesis and Characterizations of Biodegradable Polyurethane Microspheres with Dexamethasone for Drug Delivery

AU - Park, Juri

AU - Lee, Min Jeong

AU - Ahn, Guk Young

AU - Yun, Tae Hoon

AU - Choi, Inseong

AU - Lee, Eun Seong

AU - Lee, Hyunsuk

AU - Choi, Sung Wook

PY - 2019/9/1

Y1 - 2019/9/1

N2 - This manuscript reports on the synthesis of biodegradable polyurethanes (PU) using poly(ε-caprolactone) diol and fabrication of microspheres containing dexamethasone (DEX). Biodegradable PUs with different isocyanate ratios were successfully synthesized using PCL diol as a polyol. The PU with a high isocyanate ratio exhibited a low average molecular weight, high melting point, high Young’s modulus, low tensile strength, low elongation to break, low hydrolytic degradation rate, and fast release profile of DEX. These results can be used to optimize properties so as to be suitable for specific applications. Our next goal is to evaluate the performance of PU microspheres as an injectable cartilage filler through in vitro and in vivo studies. In addition, the biodegradable PUs can be used for tissue-engineered scaffolds using three-dimensional printing. [Figure not available: see fulltext.].

AB - This manuscript reports on the synthesis of biodegradable polyurethanes (PU) using poly(ε-caprolactone) diol and fabrication of microspheres containing dexamethasone (DEX). Biodegradable PUs with different isocyanate ratios were successfully synthesized using PCL diol as a polyol. The PU with a high isocyanate ratio exhibited a low average molecular weight, high melting point, high Young’s modulus, low tensile strength, low elongation to break, low hydrolytic degradation rate, and fast release profile of DEX. These results can be used to optimize properties so as to be suitable for specific applications. Our next goal is to evaluate the performance of PU microspheres as an injectable cartilage filler through in vitro and in vivo studies. In addition, the biodegradable PUs can be used for tissue-engineered scaffolds using three-dimensional printing. [Figure not available: see fulltext.].

KW - biodegradation

KW - dexamethasone

KW - microsphere

KW - polyurethane

UR - https://www.scopus.com/pages/publications/85070960922

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M3 - Article

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EP - 842

JO - Macromolecular Research

JF - Macromolecular Research

IS - 9

ER -

Synthesis and Characterizations of Biodegradable Polyurethane Microspheres with Dexamethasone for Drug Delivery

Abstract

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Keywords

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