TAAR 6 and HSP-70 variations associated with bipolar disorder

Chi Un Pae; Antonio Drago; Laura Mandelli; Diana De Ronchi; Alessandro Serretti

doi:10.1016/j.neulet.2009.09.025

TAAR 6 and HSP-70 variations associated with bipolar disorder

Chi Un Pae
, Antonio Drago
, Laura Mandelli
, Diana De Ronchi
, Alessandro Serretti

Department of Psychiatry

University of Bologna

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We report on the impact of a set of variations located in the HSP-70 (heat shock protein 70) and TAAR6 (trace amine associated receptors 6 gene) in a sample of bipolar patients. Holding a diagnosis of BPD was the first outcome measure. Response to pharmacotreatment in bipolar patients was the secondary outcome measure. One hundred seventy-one bipolar patients and 288 controls were enrolled for the study. Patients were administered HAM-D, YMRS and CGI at baseline and discharge by independent psychiatrists blind to genotypes. As a result, homozygosis at rs2075799 (HSP-70) was found to be more represented in controls than in cases (p = 0.000009). The investigated variations did not show impact on treatment outcome. This study provides preliminary evidence that HSP-70 may play a role in the disrupted mechanisms that lead to BPD. Further confirmatory analyses in this direction are mandatory.

Original language	English
Pages (from-to)	257-261
Number of pages	5
Journal	Neuroscience Letters
Volume	465
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2009.09.025
State	Published - 20 Nov 2009

Bibliographical note

Funding Information:
This work was supported by a financial support of the Catholic Medical Center Research Foundation made in the program year of 2009 and by a grant from the Medical Research Center, Korea Science and Engineering Foundation, Republic of Korea ( R13-2002-005-04001-0 ).

Keywords

Association
Bipolar disorder
Gene
Heat shock proteins
Trace amine associated receptor

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10.1016/j.neulet.2009.09.025

Cite this

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title = "TAAR 6 and HSP-70 variations associated with bipolar disorder",

abstract = "We report on the impact of a set of variations located in the HSP-70 (heat shock protein 70) and TAAR6 (trace amine associated receptors 6 gene) in a sample of bipolar patients. Holding a diagnosis of BPD was the first outcome measure. Response to pharmacotreatment in bipolar patients was the secondary outcome measure. One hundred seventy-one bipolar patients and 288 controls were enrolled for the study. Patients were administered HAM-D, YMRS and CGI at baseline and discharge by independent psychiatrists blind to genotypes. As a result, homozygosis at rs2075799 (HSP-70) was found to be more represented in controls than in cases (p = 0.000009). The investigated variations did not show impact on treatment outcome. This study provides preliminary evidence that HSP-70 may play a role in the disrupted mechanisms that lead to BPD. Further confirmatory analyses in this direction are mandatory.",

keywords = "Association, Bipolar disorder, Gene, Heat shock proteins, Trace amine associated receptor",

author = "Pae, \{Chi Un\} and Antonio Drago and Laura Mandelli and \{De Ronchi\}, Diana and Alessandro Serretti",

note = "Funding Information: This work was supported by a financial support of the Catholic Medical Center Research Foundation made in the program year of 2009 and by a grant from the Medical Research Center, Korea Science and Engineering Foundation, Republic of Korea ( R13-2002-005-04001-0 ).",

year = "2009",

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doi = "10.1016/j.neulet.2009.09.025",

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AU - Pae, Chi Un

AU - Drago, Antonio

AU - Mandelli, Laura

AU - De Ronchi, Diana

AU - Serretti, Alessandro

N1 - Funding Information: This work was supported by a financial support of the Catholic Medical Center Research Foundation made in the program year of 2009 and by a grant from the Medical Research Center, Korea Science and Engineering Foundation, Republic of Korea ( R13-2002-005-04001-0 ).

PY - 2009/11/20

Y1 - 2009/11/20

N2 - We report on the impact of a set of variations located in the HSP-70 (heat shock protein 70) and TAAR6 (trace amine associated receptors 6 gene) in a sample of bipolar patients. Holding a diagnosis of BPD was the first outcome measure. Response to pharmacotreatment in bipolar patients was the secondary outcome measure. One hundred seventy-one bipolar patients and 288 controls were enrolled for the study. Patients were administered HAM-D, YMRS and CGI at baseline and discharge by independent psychiatrists blind to genotypes. As a result, homozygosis at rs2075799 (HSP-70) was found to be more represented in controls than in cases (p = 0.000009). The investigated variations did not show impact on treatment outcome. This study provides preliminary evidence that HSP-70 may play a role in the disrupted mechanisms that lead to BPD. Further confirmatory analyses in this direction are mandatory.

AB - We report on the impact of a set of variations located in the HSP-70 (heat shock protein 70) and TAAR6 (trace amine associated receptors 6 gene) in a sample of bipolar patients. Holding a diagnosis of BPD was the first outcome measure. Response to pharmacotreatment in bipolar patients was the secondary outcome measure. One hundred seventy-one bipolar patients and 288 controls were enrolled for the study. Patients were administered HAM-D, YMRS and CGI at baseline and discharge by independent psychiatrists blind to genotypes. As a result, homozygosis at rs2075799 (HSP-70) was found to be more represented in controls than in cases (p = 0.000009). The investigated variations did not show impact on treatment outcome. This study provides preliminary evidence that HSP-70 may play a role in the disrupted mechanisms that lead to BPD. Further confirmatory analyses in this direction are mandatory.

KW - Association

KW - Bipolar disorder

KW - Gene

KW - Heat shock proteins

KW - Trace amine associated receptor

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DO - 10.1016/j.neulet.2009.09.025

M3 - Article

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AN - SCOPUS:70349786299

SN - 0304-3940

VL - 465

SP - 257

EP - 261

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

TAAR 6 and HSP-70 variations associated with bipolar disorder

Abstract

Bibliographical note

Keywords

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