Abstract
Objective Mitral stenosis increases the risk of atrial fibrillation (AF) and stroke. Large data underlying the trend in incidence, treatment and outcomes of mitral stenosis are lacking. Methods Based on the Health Insurance Review and Assessment Service database in Republic of Korea, patients who were diagnosed with mitral stenosis between 2007 and 2016 were enrolled. Trends in the incidence rate and changing patterns of treatment and outcome for stroke and systemic embolism and intracranial haemorrhage (ICH) were analysed. Results A total of 42 075 patients (mean age 60.7±13.5 years, 13 303 (31.6%) male) were included in the present study. The number included 27 824 (66.1%) patients with mitral stenosis and comorbid AF. The age-standardised annual incidence rate per 100 000 of mitral stenosis in Korea decreased remarkably from 10.3 to 3.6 over 10 years. The use of anticoagulation therapy increased consistently. The annual incidence of stroke and systemic embolism showed signs of plateau, while the incidence of ICH increased. Conclusions The overall incidence rate of mitral stenosis in Korean population has decreased remarkably. As increasing the use of vitamin K antagonist, the annual incidence rate of ICH was increased but the rate of stroke incidence reached a plateau. Alternative effective anticoagulation strategy should be investigated.
Original language | English |
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Pages (from-to) | 746-750 |
Number of pages | 5 |
Journal | Heart |
Volume | 106 |
Issue number | 10 |
DOIs | |
State | Published - 1 May 2020 |
Bibliographical note
Funding Information:3Department of Occupational and environmental Medicine, seoul st Mary’s hospital, college of Medicine, The catholic University of Korea, seoul, republic of Korea 4Division of cardiology, Department of internal Medicine, Daejeon st Mary’s hospital, college of Medicine, The catholic University of Korea, seoul, republic of Korea 5Division of cardiology, Department of internal Medicine, st. Vincent’s hospital, college of Medicine, The catholic University of Korea, seoul, republic of Korea 6Division of cardiology, Department of internal Medicine, st Vincent’s hospital seoul st. Mary’s hospital, college of Medicine, The catholic University of Korea, seoul, republic of Korea 7Division of cardiology, Department of internal Medicine, Yeouido st. Mary’s hospital, college of Medicine, The catholic University of Korea, seoul, republic of south Korea Acknowledgements The authors acknowledge the financial support of the catholic Medical center research Foundation given in the programme year of 2015. Funding This study was funded by catholic Medical center research Foundation. Competing interests none declared. Patient consent for publication not required. Provenance and peer review not commissioned; externally peer reviewed. data availability statement no data are available. Open access This is an open access article distributed in accordance with the creative commons attribution non commercial (cc BY-nc 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. see: http://creativecommons.org/licenses/by-nc/4.0/.
Funding Information:
The authors acknowledge the financial support of the Catholic Medical Center Research Foundation given in the programme year of 2015.
Publisher Copyright:
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Keywords
- anticoagulation
- incidence rate
- intracranial haemorrhage
- mitral stenosis
- stroke
- systemic embolism