The Cancer Spectrum Theory

Hwa Young Lee; Minkyo Song; Konrad H. Stopsack; Cheng Peng; Amanda I. Phipps; Molin Wang; Shuji Ogino; Naoko Sasamoto; Tomotaka Ugai

doi:10.1158/2159-8290.CD-23-1494

The Cancer Spectrum Theory

Hwa Young Lee, Minkyo Song, Konrad H. Stopsack, Cheng Peng, Amanda I. Phipps, Molin Wang, Shuji Ogino, Naoko Sasamoto, Tomotaka Ugai

Graduate school of public health and healthcare management

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Biological characteristics of tumors are heterogeneous, forming spectra in terms of several factors such as age at onset, anatomic spatial localization, tumor subtyping, and the degree of tumor aggressiveness (encompassing a neoplastic property spectrum). Instead of blindly using dichotomized approaches, the application of the multicategorical and continuous analysis approaches to detailed cancer spectrum data can contribute to a better understanding of the etiology of cancer, ultimately leading to effective prevention and precision oncology. We provide examples of cancer spectra and emphasize the importance of integrating the cancer spectrum theory into large-scale population cancer research.

Original language	English
Pages (from-to)	589-593
Number of pages	5
Journal	Cancer Discovery
Volume	14
Issue number	4
DOIs	https://doi.org/10.1158/2159-8290.CD-23-1494
State	Published - 1 Apr 2024

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Publisher Copyright:
© 2024 American Association for Cancer Research.

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10.1158/2159-8290.CD-23-1494

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title = "The Cancer Spectrum Theory",

abstract = "Biological characteristics of tumors are heterogeneous, forming spectra in terms of several factors such as age at onset, anatomic spatial localization, tumor subtyping, and the degree of tumor aggressiveness (encompassing a neoplastic property spectrum). Instead of blindly using dichotomized approaches, the application of the multicategorical and continuous analysis approaches to detailed cancer spectrum data can contribute to a better understanding of the etiology of cancer, ultimately leading to effective prevention and precision oncology. We provide examples of cancer spectra and emphasize the importance of integrating the cancer spectrum theory into large-scale population cancer research.",

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AU - Lee, Hwa Young

AU - Song, Minkyo

AU - Stopsack, Konrad H.

AU - Peng, Cheng

AU - Phipps, Amanda I.

AU - Wang, Molin

AU - Ogino, Shuji

AU - Sasamoto, Naoko

AU - Ugai, Tomotaka

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AB - Biological characteristics of tumors are heterogeneous, forming spectra in terms of several factors such as age at onset, anatomic spatial localization, tumor subtyping, and the degree of tumor aggressiveness (encompassing a neoplastic property spectrum). Instead of blindly using dichotomized approaches, the application of the multicategorical and continuous analysis approaches to detailed cancer spectrum data can contribute to a better understanding of the etiology of cancer, ultimately leading to effective prevention and precision oncology. We provide examples of cancer spectra and emphasize the importance of integrating the cancer spectrum theory into large-scale population cancer research.

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JO - Cancer Discovery

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The Cancer Spectrum Theory

Abstract

Bibliographical note

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