TY - JOUR
T1 - The effect of Nd:YAG laser membranotomy and intravitreal tissue plasminogen activator with gas on massive diabetic premacular hemorrhage
AU - Chung, Jin
AU - Park, Young Hoon
AU - Lee, Young Chun
PY - 2008/3
Y1 - 2008/3
N2 - ■ BACKGROUND AND OBJECTIVE: To investigate the combined therapeutic effects of Nd:YAG laser membranotomy and intravitreal tissue plasminogen activator (tPA) (Actilyse; Boehringer Ingelheim, Ingelheim, Germany) injection with perfluoropropane (C3F8, 100%) injection on massive diabetic premacular hemorrhage. ■ PATIENTS AND METHODS: Nd:YAG laser membranotomy was performed on the hemorrhagic membrane of premacular hemorrhage, and tPA (25 μg/0.1 mL) was injected into the vitreous cavity of seven eyes with massive diabetic premacular hemorrhage. For each procedure 0.2 mL of C 3F8 was also injected. ■ RESULTS: After the combined therapy, the patients recovered vision within 4 weeks and the hemorrhages were completely absorbed within 8 weeks. Visual acuity at the last follow-up visit improved to a mean of 10 logarithm of the minimum angle of resolution lines in all cases. There were no associated ophthalmic complications. ■ CONCLUSION: The combined therapy resulted in resolution of premacular hemorrhages with proliferative diabetic retinopathy and may allow for faster resolution of premacular hemorrhages and lessen the need for vitrectomy.
AB - ■ BACKGROUND AND OBJECTIVE: To investigate the combined therapeutic effects of Nd:YAG laser membranotomy and intravitreal tissue plasminogen activator (tPA) (Actilyse; Boehringer Ingelheim, Ingelheim, Germany) injection with perfluoropropane (C3F8, 100%) injection on massive diabetic premacular hemorrhage. ■ PATIENTS AND METHODS: Nd:YAG laser membranotomy was performed on the hemorrhagic membrane of premacular hemorrhage, and tPA (25 μg/0.1 mL) was injected into the vitreous cavity of seven eyes with massive diabetic premacular hemorrhage. For each procedure 0.2 mL of C 3F8 was also injected. ■ RESULTS: After the combined therapy, the patients recovered vision within 4 weeks and the hemorrhages were completely absorbed within 8 weeks. Visual acuity at the last follow-up visit improved to a mean of 10 logarithm of the minimum angle of resolution lines in all cases. There were no associated ophthalmic complications. ■ CONCLUSION: The combined therapy resulted in resolution of premacular hemorrhages with proliferative diabetic retinopathy and may allow for faster resolution of premacular hemorrhages and lessen the need for vitrectomy.
UR - https://www.scopus.com/pages/publications/42949089740
U2 - 10.3928/15428877-20080301-06
DO - 10.3928/15428877-20080301-06
M3 - Article
C2 - 18435334
AN - SCOPUS:42949089740
SN - 1542-8877
VL - 39
SP - 114
EP - 120
JO - Ophthalmic Surgery Lasers and Imaging
JF - Ophthalmic Surgery Lasers and Imaging
IS - 2
ER -
