The effect of polydeoxyribonucleotide extracted from salmon sperm on the restoration of bisphosphonate-related osteonecrosis of the jaw

Deok Won Lee; Hoon Hyun; Sungsu Lee; So Yeon Kim; Gyu Tae Kim; Sewook Um; Sung Ok Hong; Heung Jae Chun; Dae Hyeok Yang

doi:10.3390/md17010051

The effect of polydeoxyribonucleotide extracted from salmon sperm on the restoration of bisphosphonate-related osteonecrosis of the jaw

Deok Won Lee
, Hoon Hyun
, Sungsu Lee
, So Yeon Kim
, Gyu Tae Kim
, Sewook Um
, Sung Ok Hong
, Heung Jae Chun
, Dae Hyeok Yang

Department of Biomedicine & Health Science

Kyung Hee University
Chonnam National University
Cheongju University
Seoul National University
Kwandong University
The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Bisphosphonates (BPs) used for treating skeletal diseases can induce bisphosphonate-related osteonecrosis of the jaw (BRONJ). Despite much effort, effective remedies are yet to be established. In the present study, we investigated the feasibility of polydeoxyribonucleotide (PDRN) extracted from salmon sperm for the treatment of BRONJ, in a BRONJ-induced rat model. Compared with BRONJ-induced samples, PDRN-treated samples exhibited lower necrotic bone percentages and increased numbers of blood vessels and attached osteoclast production. Moreover, local administration of PDRN at a high concentration (8 mg/kg) remarkably resolved the osteonecrosis. Findings from this study suggest that local administration of PDRN at a specific concentration may be considered clinically for the management of BRONJ.

Original language	English
Article number	51
Journal	Marine Drugs
Volume	17
Issue number	1
DOIs	https://doi.org/10.3390/md17010051
State	Published - 11 Jan 2019

Bibliographical note

Publisher Copyright:
© 2019 by the authors

Keywords

Bisphosphonate
Bisphosphonate-related osteonecrosis of the jaw
Blood vessels
Necrotic bone percentages
Osteoclasts
Polydeoxyribonucleotide

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10.3390/md17010051

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title = "The effect of polydeoxyribonucleotide extracted from salmon sperm on the restoration of bisphosphonate-related osteonecrosis of the jaw",

abstract = "Bisphosphonates (BPs) used for treating skeletal diseases can induce bisphosphonate-related osteonecrosis of the jaw (BRONJ). Despite much effort, effective remedies are yet to be established. In the present study, we investigated the feasibility of polydeoxyribonucleotide (PDRN) extracted from salmon sperm for the treatment of BRONJ, in a BRONJ-induced rat model. Compared with BRONJ-induced samples, PDRN-treated samples exhibited lower necrotic bone percentages and increased numbers of blood vessels and attached osteoclast production. Moreover, local administration of PDRN at a high concentration (8 mg/kg) remarkably resolved the osteonecrosis. Findings from this study suggest that local administration of PDRN at a specific concentration may be considered clinically for the management of BRONJ.",

keywords = "Bisphosphonate, Bisphosphonate-related osteonecrosis of the jaw, Blood vessels, Necrotic bone percentages, Osteoclasts, Polydeoxyribonucleotide",

author = "Lee, \{Deok Won\} and Hoon Hyun and Sungsu Lee and Kim, \{So Yeon\} and Kim, \{Gyu Tae\} and Sewook Um and Hong, \{Sung Ok\} and Chun, \{Heung Jae\} and Yang, \{Dae Hyeok\}",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors",

year = "2019",

month = jan,

day = "11",

doi = "10.3390/md17010051",

language = "English",

volume = "17",

journal = "Marine Drugs",

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T1 - The effect of polydeoxyribonucleotide extracted from salmon sperm on the restoration of bisphosphonate-related osteonecrosis of the jaw

AU - Lee, Deok Won

AU - Hyun, Hoon

AU - Lee, Sungsu

AU - Kim, So Yeon

AU - Kim, Gyu Tae

AU - Um, Sewook

AU - Hong, Sung Ok

AU - Chun, Heung Jae

AU - Yang, Dae Hyeok

PY - 2019/1/11

Y1 - 2019/1/11

N2 - Bisphosphonates (BPs) used for treating skeletal diseases can induce bisphosphonate-related osteonecrosis of the jaw (BRONJ). Despite much effort, effective remedies are yet to be established. In the present study, we investigated the feasibility of polydeoxyribonucleotide (PDRN) extracted from salmon sperm for the treatment of BRONJ, in a BRONJ-induced rat model. Compared with BRONJ-induced samples, PDRN-treated samples exhibited lower necrotic bone percentages and increased numbers of blood vessels and attached osteoclast production. Moreover, local administration of PDRN at a high concentration (8 mg/kg) remarkably resolved the osteonecrosis. Findings from this study suggest that local administration of PDRN at a specific concentration may be considered clinically for the management of BRONJ.

AB - Bisphosphonates (BPs) used for treating skeletal diseases can induce bisphosphonate-related osteonecrosis of the jaw (BRONJ). Despite much effort, effective remedies are yet to be established. In the present study, we investigated the feasibility of polydeoxyribonucleotide (PDRN) extracted from salmon sperm for the treatment of BRONJ, in a BRONJ-induced rat model. Compared with BRONJ-induced samples, PDRN-treated samples exhibited lower necrotic bone percentages and increased numbers of blood vessels and attached osteoclast production. Moreover, local administration of PDRN at a high concentration (8 mg/kg) remarkably resolved the osteonecrosis. Findings from this study suggest that local administration of PDRN at a specific concentration may be considered clinically for the management of BRONJ.

KW - Bisphosphonate

KW - Bisphosphonate-related osteonecrosis of the jaw

KW - Blood vessels

KW - Necrotic bone percentages

KW - Osteoclasts

KW - Polydeoxyribonucleotide

UR - https://www.scopus.com/pages/publications/85059905412

U2 - 10.3390/md17010051

DO - 10.3390/md17010051

M3 - Article

C2 - 30641942

AN - SCOPUS:85059905412

SN - 1660-3397

VL - 17

JO - Marine Drugs

JF - Marine Drugs

IS - 1

M1 - 51

ER -

The effect of polydeoxyribonucleotide extracted from salmon sperm on the restoration of bisphosphonate-related osteonecrosis of the jaw

Abstract

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Keywords

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