The effect of surgical wide excision and amniotic membrane transplantation with adjuvant topical mitomycin c treatment in recurrent conjunctival-corneal intraepithelial neoplasia

Jae Hyung Lee; Yeong Hoon Kim; Man Soo Kim; Eun Chul Kim

doi:10.3109/08820538.2013.810280

The effect of surgical wide excision and amniotic membrane transplantation with adjuvant topical mitomycin c treatment in recurrent conjunctival-corneal intraepithelial neoplasia

Jae Hyung Lee
, Yeong Hoon Kim
, Man Soo Kim
, Eun Chul Kim

Department of Ophthalmology

Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Purpose: To investigate the effect of surgical wide excision and amniotic membrane transplantation with adjuvant mitomycin C 0.04% eye drops on recurrent conjunctival-corneal intraepithelial neoplasia (CCIN). Methods: The authors applied amniotic membrane transplantation after total surgical excision of a tumor to a patient with recurrent conjunctival-corneal intraepithelial neoplasia. The tumor co-existed as a conjunctival lesion and corneal opacity. After one week, the patient received mitomycin C 0.04% eye drops four times a day for one month to prevent recurrence. Ocular complications and recurrence were evaluated under slit lamp microscopy for one year. Results: Corneal epithelium completely healed within one week after the surgery. Both conjunctival and corneal lesions were completely regressed and no recurrence has been found with follow-up to 24 months. Conclusions: Surgical wide excision and amniotic membrane transplantation with adjuvant topical MMC would be an effective treatment modality for treatment of recurrent CCIN.

Original language	English
Pages (from-to)	192-195
Number of pages	4
Journal	Seminars in Ophthalmology
Volume	29
Issue number	4
DOIs	https://doi.org/10.3109/08820538.2013.810280
State	Published - Jul 2014

Bibliographical note

Funding Information:
Received 7 January 2013; accepted 26 May 2013; published online 19 August 2013 *This work was supported by a National Research Foundation of Korea Grant founded by the Korean Government (2012038648). Correspondence: Eun Chul Kim, MD, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 2 Sosa Dong, Wonmi Gu, Bucheon, Kyunggi Do, 420-717, Korea. E-mail: [email protected]

Keywords

Aamniotic membrane transplantation
Corneal opacity
Recurrent conjunctival-corneal intraepithelial neoplasia (CCIN)
Surgical wide excision
Topical mitomycin C

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10.3109/08820538.2013.810280

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title = "The effect of surgical wide excision and amniotic membrane transplantation with adjuvant topical mitomycin c treatment in recurrent conjunctival-corneal intraepithelial neoplasia",

abstract = "Purpose: To investigate the effect of surgical wide excision and amniotic membrane transplantation with adjuvant mitomycin C 0.04\% eye drops on recurrent conjunctival-corneal intraepithelial neoplasia (CCIN). Methods: The authors applied amniotic membrane transplantation after total surgical excision of a tumor to a patient with recurrent conjunctival-corneal intraepithelial neoplasia. The tumor co-existed as a conjunctival lesion and corneal opacity. After one week, the patient received mitomycin C 0.04\% eye drops four times a day for one month to prevent recurrence. Ocular complications and recurrence were evaluated under slit lamp microscopy for one year. Results: Corneal epithelium completely healed within one week after the surgery. Both conjunctival and corneal lesions were completely regressed and no recurrence has been found with follow-up to 24 months. Conclusions: Surgical wide excision and amniotic membrane transplantation with adjuvant topical MMC would be an effective treatment modality for treatment of recurrent CCIN.",

keywords = "Aamniotic membrane transplantation, Corneal opacity, Recurrent conjunctival-corneal intraepithelial neoplasia (CCIN), Surgical wide excision, Topical mitomycin C",

author = "Lee, \{Jae Hyung\} and Kim, \{Yeong Hoon\} and Kim, \{Man Soo\} and Kim, \{Eun Chul\}",

note = "Funding Information: Received 7 January 2013; accepted 26 May 2013; published online 19 August 2013 *This work was supported by a National Research Foundation of Korea Grant founded by the Korean Government (2012038648). Correspondence: Eun Chul Kim, MD, Bucheon St. Mary{\textquoteright}s Hospital, College of Medicine, The Catholic University of Korea, 2 Sosa Dong, Wonmi Gu, Bucheon, Kyunggi Do, 420-717, Korea. E-mail: [email protected]",

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The effect of surgical wide excision and amniotic membrane transplantation with adjuvant topical mitomycin c treatment in recurrent conjunctival-corneal intraepithelial neoplasia. / Lee, Jae Hyung; Kim, Yeong Hoon; Kim, Man Soo et al.
In: Seminars in Ophthalmology, Vol. 29, No. 4, 07.2014, p. 192-195.

Research output: Contribution to journal › Article › peer-review

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T1 - The effect of surgical wide excision and amniotic membrane transplantation with adjuvant topical mitomycin c treatment in recurrent conjunctival-corneal intraepithelial neoplasia

AU - Lee, Jae Hyung

AU - Kim, Yeong Hoon

AU - Kim, Man Soo

AU - Kim, Eun Chul

N1 - Funding Information: Received 7 January 2013; accepted 26 May 2013; published online 19 August 2013 *This work was supported by a National Research Foundation of Korea Grant founded by the Korean Government (2012038648). Correspondence: Eun Chul Kim, MD, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 2 Sosa Dong, Wonmi Gu, Bucheon, Kyunggi Do, 420-717, Korea. E-mail: [email protected]

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N2 - Purpose: To investigate the effect of surgical wide excision and amniotic membrane transplantation with adjuvant mitomycin C 0.04% eye drops on recurrent conjunctival-corneal intraepithelial neoplasia (CCIN). Methods: The authors applied amniotic membrane transplantation after total surgical excision of a tumor to a patient with recurrent conjunctival-corneal intraepithelial neoplasia. The tumor co-existed as a conjunctival lesion and corneal opacity. After one week, the patient received mitomycin C 0.04% eye drops four times a day for one month to prevent recurrence. Ocular complications and recurrence were evaluated under slit lamp microscopy for one year. Results: Corneal epithelium completely healed within one week after the surgery. Both conjunctival and corneal lesions were completely regressed and no recurrence has been found with follow-up to 24 months. Conclusions: Surgical wide excision and amniotic membrane transplantation with adjuvant topical MMC would be an effective treatment modality for treatment of recurrent CCIN.

AB - Purpose: To investigate the effect of surgical wide excision and amniotic membrane transplantation with adjuvant mitomycin C 0.04% eye drops on recurrent conjunctival-corneal intraepithelial neoplasia (CCIN). Methods: The authors applied amniotic membrane transplantation after total surgical excision of a tumor to a patient with recurrent conjunctival-corneal intraepithelial neoplasia. The tumor co-existed as a conjunctival lesion and corneal opacity. After one week, the patient received mitomycin C 0.04% eye drops four times a day for one month to prevent recurrence. Ocular complications and recurrence were evaluated under slit lamp microscopy for one year. Results: Corneal epithelium completely healed within one week after the surgery. Both conjunctival and corneal lesions were completely regressed and no recurrence has been found with follow-up to 24 months. Conclusions: Surgical wide excision and amniotic membrane transplantation with adjuvant topical MMC would be an effective treatment modality for treatment of recurrent CCIN.

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The effect of surgical wide excision and amniotic membrane transplantation with adjuvant topical mitomycin c treatment in recurrent conjunctival-corneal intraepithelial neoplasia

Abstract

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Keywords

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