The effects of muscle mass and quality on mortality of patients with acute kidney injury requiring continuous renal replacement therapy

Jiyun Jung, Jangwook Lee, Jeong Hoon Lim, Yong Chul Kim, Tae Hyun Ban, Woo Yeong Park, Kyeong Min Kim, Kipyo Kim, Sung Woo Lee, Sung Joon Shin, Seung Seok Han, Dong Ki Kim, Yousun Ko, Kyung Won Kim, Hyosang Kim, Jae Yoon Park

Research output: Contribution to journalArticlepeer-review

Abstract

This study examined the effects of muscle mass on mortality in patients with acute kidney injury requiring continuous renal replacement therapy. It was conducted in eight medical centers between 2006 and 2021. The data of 2200 patients over the age of 18 years with acute kidney injury who required continuous renal replacement therapy were retrospectively collected. Skeletal muscle areas, categorized into normal and low attenuation muscle areas, were obtained from computed tomography images at the level of the third lumbar vertebra. Cox proportional hazards models were used to investigate the association between mortality within 1, 3, and 30 days and skeletal muscle index. Sixty percent of patients were male, and the 30-day mortality rate was 52%. Increased skeletal muscle areas/body mass index was associated with decreased mortality risk. We also identified a 26% decreased risk of low attenuation muscle area/body mass index on mortality. We established that muscle mass had protective effects on the mortality of patients with acute kidney injury requiring continuous renal replacement therapy. This study showed that muscle mass is a significant determinant of mortality, even if the density is low.

Original languageEnglish
Article number7311
JournalScientific Reports
Volume13
Issue number1
DOIs
StatePublished - Dec 2023

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© 2023, The Author(s).

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