Abstract
Objective: The present study aimed to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) at a high frequency using a miniaturized device compared to standard rTMS and sham rTMS for the treatment of depression. Methods: Fifty-four patients with depression were randomly assigned to either 15 days of miniaturized, standard, or sham rTMS. The stimulation consisted of 60 trains of 5 seconds at 10 Hz for 30 minutes. Clinical measures were assessed at baseline and on the final day of the stimulation. Results: A repeated-measures analysis of variance revealed a significant main effect of time and a time by group interaction on Hamilton Rating Scale for Depression scores. There were no significant correlations between individual motor thresholds and changes of clinical outcomes. Our results revealed a significant reduction in the Hamilton Rating Scale for Depression in the miniaturized and standard groups compared to the sham group. Conclusion: The antidepressant utility of miniaturized rTMS using subthreshold stimulation was comparable to that of standard stimulation.
| Original language | English |
|---|---|
| Pages (from-to) | 409-414 |
| Number of pages | 6 |
| Journal | Clinical Psychopharmacology and Neuroscience |
| Volume | 17 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2019 |
Bibliographical note
Publisher Copyright:Copyright © 2019, Korean College of Neuropsychopharmacology.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Antidepressants
- Depression
- Transcranial magnetic stimulation
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