The functional effect of epigallocatechin gallate on ischemic stroke in rats

Seong Hoon Lim; Han Seung Kim; Young Kook Kim; Tae Min Kim; Sun Im; Myung Eun Chung; Bo Young Hong; Young Jin Ko; Hye Won Kim; Jong In Lee

doi:10.55782/ane-2010-1772

The functional effect of epigallocatechin gallate on ischemic stroke in rats

Seong Hoon Lim
, Han Seung Kim
, Young Kook Kim
, Tae Min Kim
, Sun Im
, Myung Eun Chung
, Bo Young Hong
, Young Jin Ko
, Hye Won Kim
, Jong In Lee

The Catholic University of Korea, College of Medicine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

We evaluated the efficacy of epigallocatechin gallate (EGCG) for improving function in rats with transient middle cerebral artery occlusion (MCAO). Three procedures underwent for each groups; MCAO and EGCG treatment, MCAO without treatment (MCAO control), and sham operation. Function was evaluated on days 1, 5, 10, and 14 after ischemia, using a modified sticky-tape test and the percentage weight borne on the paretic leg. Infarct volume did not differ between the EGCG-treated and MCAO control groups. Compared with the MCAO control group, the EGCG-treated group showed improved forelimb function and had normal function by day 10 (P<0.05). The improvements persisted until day 14 postischemia. In contrast, hind limb function did not differ between the EGCG-treated and MCAO control groups. Thus, EGCG improved certain aspects of function of forelimb until day 14 after MCAO in rats.

Original language	English
Pages (from-to)	40-46
Number of pages	7
Journal	Acta Neurobiologiae Experimentalis
Volume	70
Issue number	1
DOIs	https://doi.org/10.55782/ane-2010-1772
State	Published - 2010

Keywords

Catechin
EGCG
Epigallocatechin gallate
Functional improvement
Middle cerebral artery occlusion

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title = "The functional effect of epigallocatechin gallate on ischemic stroke in rats",

abstract = "We evaluated the efficacy of epigallocatechin gallate (EGCG) for improving function in rats with transient middle cerebral artery occlusion (MCAO). Three procedures underwent for each groups; MCAO and EGCG treatment, MCAO without treatment (MCAO control), and sham operation. Function was evaluated on days 1, 5, 10, and 14 after ischemia, using a modified sticky-tape test and the percentage weight borne on the paretic leg. Infarct volume did not differ between the EGCG-treated and MCAO control groups. Compared with the MCAO control group, the EGCG-treated group showed improved forelimb function and had normal function by day 10 (P<0.05). The improvements persisted until day 14 postischemia. In contrast, hind limb function did not differ between the EGCG-treated and MCAO control groups. Thus, EGCG improved certain aspects of function of forelimb until day 14 after MCAO in rats.",

keywords = "Catechin, EGCG, Epigallocatechin gallate, Functional improvement, Middle cerebral artery occlusion",

author = "Lim, \{Seong Hoon\} and Kim, \{Han Seung\} and Kim, \{Young Kook\} and Kim, \{Tae Min\} and Sun Im and Chung, \{Myung Eun\} and Hong, \{Bo Young\} and Ko, \{Young Jin\} and Kim, \{Hye Won\} and Lee, \{Jong In\}",

year = "2010",

doi = "10.55782/ane-2010-1772",

language = "English",

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pages = "40--46",

journal = "Acta Neurobiologiae Experimentalis",

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T1 - The functional effect of epigallocatechin gallate on ischemic stroke in rats

AU - Lim, Seong Hoon

AU - Kim, Han Seung

AU - Kim, Young Kook

AU - Kim, Tae Min

AU - Im, Sun

AU - Chung, Myung Eun

AU - Hong, Bo Young

AU - Ko, Young Jin

AU - Kim, Hye Won

AU - Lee, Jong In

PY - 2010

Y1 - 2010

N2 - We evaluated the efficacy of epigallocatechin gallate (EGCG) for improving function in rats with transient middle cerebral artery occlusion (MCAO). Three procedures underwent for each groups; MCAO and EGCG treatment, MCAO without treatment (MCAO control), and sham operation. Function was evaluated on days 1, 5, 10, and 14 after ischemia, using a modified sticky-tape test and the percentage weight borne on the paretic leg. Infarct volume did not differ between the EGCG-treated and MCAO control groups. Compared with the MCAO control group, the EGCG-treated group showed improved forelimb function and had normal function by day 10 (P<0.05). The improvements persisted until day 14 postischemia. In contrast, hind limb function did not differ between the EGCG-treated and MCAO control groups. Thus, EGCG improved certain aspects of function of forelimb until day 14 after MCAO in rats.

AB - We evaluated the efficacy of epigallocatechin gallate (EGCG) for improving function in rats with transient middle cerebral artery occlusion (MCAO). Three procedures underwent for each groups; MCAO and EGCG treatment, MCAO without treatment (MCAO control), and sham operation. Function was evaluated on days 1, 5, 10, and 14 after ischemia, using a modified sticky-tape test and the percentage weight borne on the paretic leg. Infarct volume did not differ between the EGCG-treated and MCAO control groups. Compared with the MCAO control group, the EGCG-treated group showed improved forelimb function and had normal function by day 10 (P<0.05). The improvements persisted until day 14 postischemia. In contrast, hind limb function did not differ between the EGCG-treated and MCAO control groups. Thus, EGCG improved certain aspects of function of forelimb until day 14 after MCAO in rats.

KW - Catechin

KW - EGCG

KW - Epigallocatechin gallate

KW - Functional improvement

KW - Middle cerebral artery occlusion

UR - https://www.scopus.com/pages/publications/77952172690

U2 - 10.55782/ane-2010-1772

DO - 10.55782/ane-2010-1772

M3 - Article

C2 - 20407485

AN - SCOPUS:77952172690

SN - 0065-1400

VL - 70

SP - 40

EP - 46

JO - Acta Neurobiologiae Experimentalis

JF - Acta Neurobiologiae Experimentalis

IS - 1

ER -

The functional effect of epigallocatechin gallate on ischemic stroke in rats

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Keywords

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