The hypoxia–long noncoding rna interaction in solid cancers

Seung Wan Son; Ba Da Yun; Mun Gyu Song; Jin Kyeong Lee; Soo Young Choi; Hyo Jeong Kuh; Jong Kook Park

doi:10.3390/ijms22147261

The hypoxia–long noncoding rna interaction in solid cancers

Seung Wan Son, Ba Da Yun, Mun Gyu Song, Jin Kyeong Lee, Soo Young Choi, Hyo Jeong Kuh, Jong Kook Park

Department of Biomedicine & Health Science

Hallym University

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Hypoxia is one of the representative microenvironment features in cancer and is considered to be associated with the dismal prognosis of patients. Hypoxia-driven cellular pathways are largely regulated by hypoxia-inducible factors (HIFs) and notably exert influence on the hallmarks of cancer, such as stemness, angiogenesis, invasion, metastasis, and the resistance towards apoptotic cell death and therapeutic resistance; therefore, hypoxia has been considered as a potential hurdle for cancer therapy. Growing evidence has demonstrated that long noncoding RNAs (lncRNAs) are dysregulated in cancer and take part in gene regulatory networks owing to their various modes of action through interacting with proteins and microRNAs. In this review, we focus attention on the relationship between hypoxia/HIFs and lncRNAs, in company with the possibility of lncRNAs as candidate molecules for controlling cancer.

Original language	English
Article number	7261
Journal	International Journal of Molecular Sciences
Volume	22
Issue number	14
DOIs	https://doi.org/10.3390/ijms22147261
State	Published - 2 Jul 2021

Bibliographical note

Funding Information:
(H.J.K.), and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (2019R1A6A1A11036849) (S.Y.C.).

Funding Information:
Funding: This work was supported by a grant from the National Research Foundation of Korea (NRF), grant funded by the Korean government (MSIT) (2019R1A2C1089710) (J.K.P.) (2019R1A2B5B02070524)

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Cancer
HIF
hypoxia
Hypoxia-inducible factors
Long noncoding RNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms22147261

Cite this

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title = "The hypoxia–long noncoding rna interaction in solid cancers",

abstract = "Hypoxia is one of the representative microenvironment features in cancer and is considered to be associated with the dismal prognosis of patients. Hypoxia-driven cellular pathways are largely regulated by hypoxia-inducible factors (HIFs) and notably exert influence on the hallmarks of cancer, such as stemness, angiogenesis, invasion, metastasis, and the resistance towards apoptotic cell death and therapeutic resistance; therefore, hypoxia has been considered as a potential hurdle for cancer therapy. Growing evidence has demonstrated that long noncoding RNAs (lncRNAs) are dysregulated in cancer and take part in gene regulatory networks owing to their various modes of action through interacting with proteins and microRNAs. In this review, we focus attention on the relationship between hypoxia/HIFs and lncRNAs, in company with the possibility of lncRNAs as candidate molecules for controlling cancer.",

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note = "Funding Information: (H.J.K.), and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (2019R1A6A1A11036849) (S.Y.C.). Funding Information: Funding: This work was supported by a grant from the National Research Foundation of Korea (NRF), grant funded by the Korean government (MSIT) (2019R1A2C1089710) (J.K.P.) (2019R1A2B5B02070524) Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Son, Seung Wan

AU - Yun, Ba Da

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AU - Choi, Soo Young

AU - Kuh, Hyo Jeong

AU - Park, Jong Kook

N1 - Funding Information: (H.J.K.), and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (2019R1A6A1A11036849) (S.Y.C.). Funding Information: Funding: This work was supported by a grant from the National Research Foundation of Korea (NRF), grant funded by the Korean government (MSIT) (2019R1A2C1089710) (J.K.P.) (2019R1A2B5B02070524) Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/7/2

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N2 - Hypoxia is one of the representative microenvironment features in cancer and is considered to be associated with the dismal prognosis of patients. Hypoxia-driven cellular pathways are largely regulated by hypoxia-inducible factors (HIFs) and notably exert influence on the hallmarks of cancer, such as stemness, angiogenesis, invasion, metastasis, and the resistance towards apoptotic cell death and therapeutic resistance; therefore, hypoxia has been considered as a potential hurdle for cancer therapy. Growing evidence has demonstrated that long noncoding RNAs (lncRNAs) are dysregulated in cancer and take part in gene regulatory networks owing to their various modes of action through interacting with proteins and microRNAs. In this review, we focus attention on the relationship between hypoxia/HIFs and lncRNAs, in company with the possibility of lncRNAs as candidate molecules for controlling cancer.

AB - Hypoxia is one of the representative microenvironment features in cancer and is considered to be associated with the dismal prognosis of patients. Hypoxia-driven cellular pathways are largely regulated by hypoxia-inducible factors (HIFs) and notably exert influence on the hallmarks of cancer, such as stemness, angiogenesis, invasion, metastasis, and the resistance towards apoptotic cell death and therapeutic resistance; therefore, hypoxia has been considered as a potential hurdle for cancer therapy. Growing evidence has demonstrated that long noncoding RNAs (lncRNAs) are dysregulated in cancer and take part in gene regulatory networks owing to their various modes of action through interacting with proteins and microRNAs. In this review, we focus attention on the relationship between hypoxia/HIFs and lncRNAs, in company with the possibility of lncRNAs as candidate molecules for controlling cancer.

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The hypoxia–long noncoding rna interaction in solid cancers

Abstract

Bibliographical note

Keywords

UN SDGs

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