The MIR-24-3p/p130Cas: A novel axis regulating the migration and invasion of cancer cells

Hoin Kang; Jun Gi Rho; Chongtae Kim; Hyosun Tak; Heejin Lee; Eunbyul Ji; Sojin Ahn; A. Ri Shin; Hyun Il Cho; Yun Hyun Huh; Woo Keun Song; Wook Kim; Eun Kyung Lee

doi:10.1038/srep44847

The MIR-24-3p/p130Cas: A novel axis regulating the migration and invasion of cancer cells

Hoin Kang
, Jun Gi Rho
, Chongtae Kim
, Hyosun Tak
, Heejin Lee
, Eunbyul Ji
, Sojin Ahn
, A. Ri Shin
, Hyun Il Cho
, Yun Hyun Huh
, Woo Keun Song
, Wook Kim
, Eun Kyung Lee

Department of Biochemistry

The Catholic University of Korea, College of Medicine
Ajou University
Gwangju Institute of Science and Technology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression by suppressing translation or facilitating mRNA decay. Differential expression of miRNAs is involved in the pathogenesis of several diseases including cancer. Here, we investigated the role of-miR-24-3p as a downregulated miRNA in metastatic cancer. miR-24-3p was decreased in metastatic cancer and lower expression of miR-24-3p was related to poor survival of cancer patients. Consistently, ectopic expression of miR-24-3p suppressed the cell migration, invasion, and proliferation of MCF7, Hep3B, B16F10, SK-Hep1, and PC-3 cells by directly targeting p130Cas. Stable expression of p130Cas restored miR-24-3p-mediated inhibition of cell migration and invasion. These results suggest that miR-24-3p functions as a tumor suppressor and the miR-24-3p/p130Cas axis is a novel factor of cancer progression by regulating cell migration and invasion.

Original language	English
Article number	44847
Journal	Scientific Reports
Volume	7
DOIs	https://doi.org/10.1038/srep44847
State	Published - 24 Mar 2017

Bibliographical note

Publisher Copyright:
© The Author(s) 2017.

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@article{9660a7de7a0c41fe9e3bea562cdd32e0,

title = "The MIR-24-3p/p130Cas: A novel axis regulating the migration and invasion of cancer cells",

abstract = "MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression by suppressing translation or facilitating mRNA decay. Differential expression of miRNAs is involved in the pathogenesis of several diseases including cancer. Here, we investigated the role of-miR-24-3p as a downregulated miRNA in metastatic cancer. miR-24-3p was decreased in metastatic cancer and lower expression of miR-24-3p was related to poor survival of cancer patients. Consistently, ectopic expression of miR-24-3p suppressed the cell migration, invasion, and proliferation of MCF7, Hep3B, B16F10, SK-Hep1, and PC-3 cells by directly targeting p130Cas. Stable expression of p130Cas restored miR-24-3p-mediated inhibition of cell migration and invasion. These results suggest that miR-24-3p functions as a tumor suppressor and the miR-24-3p/p130Cas axis is a novel factor of cancer progression by regulating cell migration and invasion.",

author = "Hoin Kang and Rho, \{Jun Gi\} and Chongtae Kim and Hyosun Tak and Heejin Lee and Eunbyul Ji and Sojin Ahn and Shin, \{A. Ri\} and Cho, \{Hyun Il\} and Huh, \{Yun Hyun\} and Song, \{Woo Keun\} and Wook Kim and Lee, \{Eun Kyung\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2017.",

year = "2017",

month = mar,

day = "24",

doi = "10.1038/srep44847",

language = "English",

volume = "7",

journal = "Scientific Reports",

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T1 - The MIR-24-3p/p130Cas

T2 - A novel axis regulating the migration and invasion of cancer cells

AU - Kang, Hoin

AU - Rho, Jun Gi

AU - Kim, Chongtae

AU - Tak, Hyosun

AU - Lee, Heejin

AU - Ji, Eunbyul

AU - Ahn, Sojin

AU - Shin, A. Ri

AU - Cho, Hyun Il

AU - Huh, Yun Hyun

AU - Song, Woo Keun

AU - Kim, Wook

AU - Lee, Eun Kyung

PY - 2017/3/24

Y1 - 2017/3/24

N2 - MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression by suppressing translation or facilitating mRNA decay. Differential expression of miRNAs is involved in the pathogenesis of several diseases including cancer. Here, we investigated the role of-miR-24-3p as a downregulated miRNA in metastatic cancer. miR-24-3p was decreased in metastatic cancer and lower expression of miR-24-3p was related to poor survival of cancer patients. Consistently, ectopic expression of miR-24-3p suppressed the cell migration, invasion, and proliferation of MCF7, Hep3B, B16F10, SK-Hep1, and PC-3 cells by directly targeting p130Cas. Stable expression of p130Cas restored miR-24-3p-mediated inhibition of cell migration and invasion. These results suggest that miR-24-3p functions as a tumor suppressor and the miR-24-3p/p130Cas axis is a novel factor of cancer progression by regulating cell migration and invasion.

AB - MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression by suppressing translation or facilitating mRNA decay. Differential expression of miRNAs is involved in the pathogenesis of several diseases including cancer. Here, we investigated the role of-miR-24-3p as a downregulated miRNA in metastatic cancer. miR-24-3p was decreased in metastatic cancer and lower expression of miR-24-3p was related to poor survival of cancer patients. Consistently, ectopic expression of miR-24-3p suppressed the cell migration, invasion, and proliferation of MCF7, Hep3B, B16F10, SK-Hep1, and PC-3 cells by directly targeting p130Cas. Stable expression of p130Cas restored miR-24-3p-mediated inhibition of cell migration and invasion. These results suggest that miR-24-3p functions as a tumor suppressor and the miR-24-3p/p130Cas axis is a novel factor of cancer progression by regulating cell migration and invasion.

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JF - Scientific Reports

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The MIR-24-3p/p130Cas: A novel axis regulating the migration and invasion of cancer cells

Abstract

Bibliographical note

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