The relationship between insulin-like growth factor-1 and metabolic syndrome, independent of adiponectin

Jaewon Oh; Jong Youn Kim; Sungha Park; Jong Chan Youn; Nak Hoon Son; Dong Jik Shin; Sang Hak Lee; Seok Min Kang; Sun Ha Jee; Yangsoo Jang

doi:10.1016/j.cca.2011.11.015

The relationship between insulin-like growth factor-1 and metabolic syndrome, independent of adiponectin

Jaewon Oh
, Jong Youn Kim
, Sungha Park
, Jong Chan Youn
, Nak Hoon Son
, Dong Jik Shin
, Sang Hak Lee
, Seok Min Kang
, Sun Ha Jee
, Yangsoo Jang

Department of Internal Medicine

Yonsei University

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Background: Insulin-like growth factor-1 (IGF-1) is associated with obesity and aging, and was recently linked to metabolic syndrome (MetS) and insulin resistance. However, little is known about the relationship between IGF-1 and adiponectin (adiponectin), another marker of MetS. Methods: We measured the plasma IGF-1 and adiponectin levels of 3099 subjects (1869 males, 55.9. ± 10.8. y). We applied the Korean-modified International Diabetes Foundation (k-IDF) criteria for determination of, and risk assessment for, MetS. Results: K-IDF criteria-based MetS occurred in 37.0% (n = 1146) of patients. IGF-1 (91.5 vs. 97.3. ng/ml, p. < 0.001) and adiponectin (3.95 vs. 4.23. μg/ml, p. < 0.001) were significantly lower in MetS patients than without MetS. Lower IGF-1 was associated with increasing numbers of MetS abnormalities, independent of adiponectin (p for trend. < 0.001, F = 12.615, p. < 0.001 in ANCOVA). MetS prevalence in individuals with both high IGF-1 and adiponectin levels (6.7%, n = 206) was significantly lower than in other groups. Both high IGF-1 and adiponectin group was associated with reduced MetS risk after adjusting for other confounding factors (OR 0.694, 95% CI 0.493-0.977, p = 0.036). Conclusions: IGF-1 was associated with MetS independent of adiponectin in our study. The independent relationship between IGF-1 and MetS provides insight into the pathophysiologic mechanisms of MetS.

Original language	English
Pages (from-to)	506-510
Number of pages	5
Journal	Clinica Chimica Acta
Volume	413
Issue number	3-4
DOIs	https://doi.org/10.1016/j.cca.2011.11.015
State	Published - 18 Feb 2012

Bibliographical note

Funding Information:
This study was supported by a grant A000385 from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea , and by a grant 2010-0020766 from the Public welfare & Safety research program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology, Republic of Korea .

Keywords

Adiponectin
Insulin-like growth factor-1
Metabolic syndrome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.cca.2011.11.015

Cite this

@article{9f9cf35309824f679d262ba26988f6f1,

title = "The relationship between insulin-like growth factor-1 and metabolic syndrome, independent of adiponectin",

abstract = "Background: Insulin-like growth factor-1 (IGF-1) is associated with obesity and aging, and was recently linked to metabolic syndrome (MetS) and insulin resistance. However, little is known about the relationship between IGF-1 and adiponectin (adiponectin), another marker of MetS. Methods: We measured the plasma IGF-1 and adiponectin levels of 3099 subjects (1869 males, 55.9. ± 10.8. y). We applied the Korean-modified International Diabetes Foundation (k-IDF) criteria for determination of, and risk assessment for, MetS. Results: K-IDF criteria-based MetS occurred in 37.0\% (n = 1146) of patients. IGF-1 (91.5 vs. 97.3. ng/ml, p. < 0.001) and adiponectin (3.95 vs. 4.23. μg/ml, p. < 0.001) were significantly lower in MetS patients than without MetS. Lower IGF-1 was associated with increasing numbers of MetS abnormalities, independent of adiponectin (p for trend. < 0.001, F = 12.615, p. < 0.001 in ANCOVA). MetS prevalence in individuals with both high IGF-1 and adiponectin levels (6.7\%, n = 206) was significantly lower than in other groups. Both high IGF-1 and adiponectin group was associated with reduced MetS risk after adjusting for other confounding factors (OR 0.694, 95\% CI 0.493-0.977, p = 0.036). Conclusions: IGF-1 was associated with MetS independent of adiponectin in our study. The independent relationship between IGF-1 and MetS provides insight into the pathophysiologic mechanisms of MetS.",

keywords = "Adiponectin, Insulin-like growth factor-1, Metabolic syndrome",

author = "Jaewon Oh and Kim, \{Jong Youn\} and Sungha Park and Youn, \{Jong Chan\} and Son, \{Nak Hoon\} and Shin, \{Dong Jik\} and Lee, \{Sang Hak\} and Kang, \{Seok Min\} and Jee, \{Sun Ha\} and Yangsoo Jang",

note = "Funding Information: This study was supported by a grant A000385 from the Korean Health Technology R\&D Project, Ministry of Health \& Welfare, Republic of Korea , and by a grant 2010-0020766 from the Public welfare \& Safety research program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology, Republic of Korea .",

year = "2012",

month = feb,

day = "18",

doi = "10.1016/j.cca.2011.11.015",

language = "English",

volume = "413",

pages = "506--510",

journal = "Clinica Chimica Acta",

issn = "0009-8981",

publisher = "Elsevier B.V.",

number = "3-4",

}

TY - JOUR

T1 - The relationship between insulin-like growth factor-1 and metabolic syndrome, independent of adiponectin

AU - Oh, Jaewon

AU - Kim, Jong Youn

AU - Park, Sungha

AU - Youn, Jong Chan

AU - Son, Nak Hoon

AU - Shin, Dong Jik

AU - Lee, Sang Hak

AU - Kang, Seok Min

AU - Jee, Sun Ha

AU - Jang, Yangsoo

N1 - Funding Information: This study was supported by a grant A000385 from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea , and by a grant 2010-0020766 from the Public welfare & Safety research program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology, Republic of Korea .

PY - 2012/2/18

Y1 - 2012/2/18

N2 - Background: Insulin-like growth factor-1 (IGF-1) is associated with obesity and aging, and was recently linked to metabolic syndrome (MetS) and insulin resistance. However, little is known about the relationship between IGF-1 and adiponectin (adiponectin), another marker of MetS. Methods: We measured the plasma IGF-1 and adiponectin levels of 3099 subjects (1869 males, 55.9. ± 10.8. y). We applied the Korean-modified International Diabetes Foundation (k-IDF) criteria for determination of, and risk assessment for, MetS. Results: K-IDF criteria-based MetS occurred in 37.0% (n = 1146) of patients. IGF-1 (91.5 vs. 97.3. ng/ml, p. < 0.001) and adiponectin (3.95 vs. 4.23. μg/ml, p. < 0.001) were significantly lower in MetS patients than without MetS. Lower IGF-1 was associated with increasing numbers of MetS abnormalities, independent of adiponectin (p for trend. < 0.001, F = 12.615, p. < 0.001 in ANCOVA). MetS prevalence in individuals with both high IGF-1 and adiponectin levels (6.7%, n = 206) was significantly lower than in other groups. Both high IGF-1 and adiponectin group was associated with reduced MetS risk after adjusting for other confounding factors (OR 0.694, 95% CI 0.493-0.977, p = 0.036). Conclusions: IGF-1 was associated with MetS independent of adiponectin in our study. The independent relationship between IGF-1 and MetS provides insight into the pathophysiologic mechanisms of MetS.

AB - Background: Insulin-like growth factor-1 (IGF-1) is associated with obesity and aging, and was recently linked to metabolic syndrome (MetS) and insulin resistance. However, little is known about the relationship between IGF-1 and adiponectin (adiponectin), another marker of MetS. Methods: We measured the plasma IGF-1 and adiponectin levels of 3099 subjects (1869 males, 55.9. ± 10.8. y). We applied the Korean-modified International Diabetes Foundation (k-IDF) criteria for determination of, and risk assessment for, MetS. Results: K-IDF criteria-based MetS occurred in 37.0% (n = 1146) of patients. IGF-1 (91.5 vs. 97.3. ng/ml, p. < 0.001) and adiponectin (3.95 vs. 4.23. μg/ml, p. < 0.001) were significantly lower in MetS patients than without MetS. Lower IGF-1 was associated with increasing numbers of MetS abnormalities, independent of adiponectin (p for trend. < 0.001, F = 12.615, p. < 0.001 in ANCOVA). MetS prevalence in individuals with both high IGF-1 and adiponectin levels (6.7%, n = 206) was significantly lower than in other groups. Both high IGF-1 and adiponectin group was associated with reduced MetS risk after adjusting for other confounding factors (OR 0.694, 95% CI 0.493-0.977, p = 0.036). Conclusions: IGF-1 was associated with MetS independent of adiponectin in our study. The independent relationship between IGF-1 and MetS provides insight into the pathophysiologic mechanisms of MetS.

KW - Adiponectin

KW - Insulin-like growth factor-1

KW - Metabolic syndrome

UR - https://www.scopus.com/pages/publications/84355163128

U2 - 10.1016/j.cca.2011.11.015

DO - 10.1016/j.cca.2011.11.015

M3 - Article

C2 - 22133783

AN - SCOPUS:84355163128

SN - 0009-8981

VL - 413

SP - 506

EP - 510

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

IS - 3-4

ER -

The relationship between insulin-like growth factor-1 and metabolic syndrome, independent of adiponectin

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this