The role of regulatory T cells during the attenuation of graft-versus-leukemia activity following donor leukocyte infusion in mice

Mi Sun Choi; Ji Young Lim; Byung Sik Cho; Yoo Jin Kim; Nack Gyun Chung; Dae Chul Jeong; Hyewon Youn; Chulbom Lee; Eun Young Choi; Chang Ki Min

doi:10.1016/j.leukres.2011.06.032

The role of regulatory T cells during the attenuation of graft-versus-leukemia activity following donor leukocyte infusion in mice

Mi Sun Choi
, Ji Young Lim
, Byung Sik Cho
, Yoo Jin Kim
, Nack Gyun Chung
, Dae Chul Jeong
, Hyewon Youn
, Chulbom Lee
, Eun Young Choi
, Chang Ki Min

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We investigated how the graft-versus-leukemia (GVL) effect is attenuated in the tumor microenvironment using a murine model of non-myeloablative allo-HSCT (NM-HSCT) plus delayed donor leukocyte infusion (DLI) in a haploidentical B6→F1 strain combination. In-line with aggravated leukemia growth, the proportions of effector T cells expressing IFN-γ (Teffs) in spleen were reduced and attenuated GVL activity was found to be accompanied by a rebound in CD4 ⁺Foxp3 ⁺ regulatory T cells (Tregs) in tumor-draining lymph nodes and tumor tissues. DLI-derived Tregs and Teffs may be potential indicators of presence of leukemic progression after DLI in this GVL model.

Original language	English
Pages (from-to)	1549-1556
Number of pages	8
Journal	Leukemia Research
Volume	35
Issue number	12
DOIs	https://doi.org/10.1016/j.leukres.2011.06.032
State	Published - Dec 2011

Bibliographical note

Funding Information:
This study was supported by the Korea Healthcare Technology R&D Project, Ministry of Health, Welfare & Family Affairs , Republic of Korea (grant no. A092258 ).

Keywords

Allogeneic hematopoietic stem cell transplantation
Graft-versus-host disease
Graft-versus-leukemia effect
Regulatory T cells
TGF-β

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2011.06.032

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title = "The role of regulatory T cells during the attenuation of graft-versus-leukemia activity following donor leukocyte infusion in mice",

abstract = "We investigated how the graft-versus-leukemia (GVL) effect is attenuated in the tumor microenvironment using a murine model of non-myeloablative allo-HSCT (NM-HSCT) plus delayed donor leukocyte infusion (DLI) in a haploidentical B6→F1 strain combination. In-line with aggravated leukemia growth, the proportions of effector T cells expressing IFN-γ (Teffs) in spleen were reduced and attenuated GVL activity was found to be accompanied by a rebound in CD4 +Foxp3 + regulatory T cells (Tregs) in tumor-draining lymph nodes and tumor tissues. DLI-derived Tregs and Teffs may be potential indicators of presence of leukemic progression after DLI in this GVL model.",

keywords = "Allogeneic hematopoietic stem cell transplantation, Graft-versus-host disease, Graft-versus-leukemia effect, Regulatory T cells, TGF-β",

author = "Choi, \{Mi Sun\} and Lim, \{Ji Young\} and Cho, \{Byung Sik\} and Kim, \{Yoo Jin\} and Chung, \{Nack Gyun\} and Jeong, \{Dae Chul\} and Hyewon Youn and Chulbom Lee and Choi, \{Eun Young\} and Min, \{Chang Ki\}",

note = "Funding Information: This study was supported by the Korea Healthcare Technology R\&D Project, Ministry of Health, Welfare \& Family Affairs , Republic of Korea (grant no. A092258 ). ",

year = "2011",

month = dec,

doi = "10.1016/j.leukres.2011.06.032",

language = "English",

volume = "35",

pages = "1549--1556",

journal = "Leukemia Research",

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T1 - The role of regulatory T cells during the attenuation of graft-versus-leukemia activity following donor leukocyte infusion in mice

AU - Choi, Mi Sun

AU - Lim, Ji Young

AU - Cho, Byung Sik

AU - Kim, Yoo Jin

AU - Chung, Nack Gyun

AU - Jeong, Dae Chul

AU - Youn, Hyewon

AU - Lee, Chulbom

AU - Choi, Eun Young

AU - Min, Chang Ki

N1 - Funding Information: This study was supported by the Korea Healthcare Technology R&D Project, Ministry of Health, Welfare & Family Affairs , Republic of Korea (grant no. A092258 ).

PY - 2011/12

Y1 - 2011/12

N2 - We investigated how the graft-versus-leukemia (GVL) effect is attenuated in the tumor microenvironment using a murine model of non-myeloablative allo-HSCT (NM-HSCT) plus delayed donor leukocyte infusion (DLI) in a haploidentical B6→F1 strain combination. In-line with aggravated leukemia growth, the proportions of effector T cells expressing IFN-γ (Teffs) in spleen were reduced and attenuated GVL activity was found to be accompanied by a rebound in CD4 +Foxp3 + regulatory T cells (Tregs) in tumor-draining lymph nodes and tumor tissues. DLI-derived Tregs and Teffs may be potential indicators of presence of leukemic progression after DLI in this GVL model.

AB - We investigated how the graft-versus-leukemia (GVL) effect is attenuated in the tumor microenvironment using a murine model of non-myeloablative allo-HSCT (NM-HSCT) plus delayed donor leukocyte infusion (DLI) in a haploidentical B6→F1 strain combination. In-line with aggravated leukemia growth, the proportions of effector T cells expressing IFN-γ (Teffs) in spleen were reduced and attenuated GVL activity was found to be accompanied by a rebound in CD4 +Foxp3 + regulatory T cells (Tregs) in tumor-draining lymph nodes and tumor tissues. DLI-derived Tregs and Teffs may be potential indicators of presence of leukemic progression after DLI in this GVL model.

KW - Allogeneic hematopoietic stem cell transplantation

KW - Graft-versus-host disease

KW - Graft-versus-leukemia effect

KW - Regulatory T cells

KW - TGF-β

UR - https://www.scopus.com/pages/publications/80055107559

U2 - 10.1016/j.leukres.2011.06.032

DO - 10.1016/j.leukres.2011.06.032

M3 - Article

C2 - 21782242

AN - SCOPUS:80055107559

SN - 0145-2126

VL - 35

SP - 1549

EP - 1556

JO - Leukemia Research

JF - Leukemia Research

IS - 12

ER -

The role of regulatory T cells during the attenuation of graft-versus-leukemia activity following donor leukocyte infusion in mice

Abstract

Bibliographical note

Keywords

UN SDGs

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