Theranostic potential of biodegradable polymeric nanoparticles with paclitaxel and curcumin against breast carcinoma

Kyu Ri Kim; Su Jung You; Hyun Joo Kim; Dae Hyeok Yang; Heung Jae Chun; Dongwon Lee; Gilson Khang

doi:10.1039/d1bm00370d

Theranostic potential of biodegradable polymeric nanoparticles with paclitaxel and curcumin against breast carcinoma

Kyu Ri Kim, Su Jung You, Hyun Joo Kim, Dae Hyeok Yang, Heung Jae Chun, Dongwon Lee, Gilson Khang

Department of Biomedicine & Health Science

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

In this study, integrin-mediated targeting and near-infrared fluorescence (NIRF) traceable polyethylene glycol-b-poly(lactic-co-glycolic acid) (PEG-PLGA)-based polymeric nanoparticles (NPs) were prepared to investigate the effects of paclitaxel (PTX) and curcumin (CUR) combination therapy on breast cancer. Cyclic (arginine-glycine-aspartic acid-phenylalanine-lysine) (cRGDfK) was selected as a ligand for breast cancer and conjugated to the end of NPs (cRGDfK-NPs). For fluorescence imaging, sulfo-cyanine 5.5 (Cy5.5) was incorporated into NPs (Cy5.5-NPs). A series of hybrid NPs consisting of NPs, cRGDfK-NPs, and Cy5.5-NPs with drugs encapsulated inside the core (Cy5.5-cRGDfK-NPs/PTX + CUR) were prepared by self-assembly. The efficacy of PTX and CUR combination and the ability of the integrin-mediated targeting of NPs were systemically investigated using a 4T1 mouse breast cancer cell line and a nude mouse xenograft model. We suggested that Cy5.5-cRGDfK-NPs/PTX + CUR has superior theranostic potential against breast carcinoma.

Original language	English
Pages (from-to)	3750-3761
Number of pages	12
Journal	Biomaterials Science
Volume	9
Issue number	10
DOIs	https://doi.org/10.1039/d1bm00370d
State	Published - 21 May 2021

Bibliographical note

Funding Information:
This research was supported by a grant from the Korean Ministry of Trade, Industry, and Energy (MOTIE, Grant No. 10047811).

Publisher Copyright:
© The Royal Society of Chemistry.

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title = "Theranostic potential of biodegradable polymeric nanoparticles with paclitaxel and curcumin against breast carcinoma",

abstract = "In this study, integrin-mediated targeting and near-infrared fluorescence (NIRF) traceable polyethylene glycol-b-poly(lactic-co-glycolic acid) (PEG-PLGA)-based polymeric nanoparticles (NPs) were prepared to investigate the effects of paclitaxel (PTX) and curcumin (CUR) combination therapy on breast cancer. Cyclic (arginine-glycine-aspartic acid-phenylalanine-lysine) (cRGDfK) was selected as a ligand for breast cancer and conjugated to the end of NPs (cRGDfK-NPs). For fluorescence imaging, sulfo-cyanine 5.5 (Cy5.5) was incorporated into NPs (Cy5.5-NPs). A series of hybrid NPs consisting of NPs, cRGDfK-NPs, and Cy5.5-NPs with drugs encapsulated inside the core (Cy5.5-cRGDfK-NPs/PTX + CUR) were prepared by self-assembly. The efficacy of PTX and CUR combination and the ability of the integrin-mediated targeting of NPs were systemically investigated using a 4T1 mouse breast cancer cell line and a nude mouse xenograft model. We suggested that Cy5.5-cRGDfK-NPs/PTX + CUR has superior theranostic potential against breast carcinoma.",

author = "Kim, {Kyu Ri} and You, {Su Jung} and Kim, {Hyun Joo} and Yang, {Dae Hyeok} and Chun, {Heung Jae} and Dongwon Lee and Gilson Khang",

note = "Funding Information: This research was supported by a grant from the Korean Ministry of Trade, Industry, and Energy (MOTIE, Grant No. 10047811). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

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AU - Kim, Kyu Ri

AU - You, Su Jung

AU - Kim, Hyun Joo

AU - Yang, Dae Hyeok

AU - Chun, Heung Jae

AU - Lee, Dongwon

AU - Khang, Gilson

N1 - Funding Information: This research was supported by a grant from the Korean Ministry of Trade, Industry, and Energy (MOTIE, Grant No. 10047811). Publisher Copyright: © The Royal Society of Chemistry.

PY - 2021/5/21

Y1 - 2021/5/21

N2 - In this study, integrin-mediated targeting and near-infrared fluorescence (NIRF) traceable polyethylene glycol-b-poly(lactic-co-glycolic acid) (PEG-PLGA)-based polymeric nanoparticles (NPs) were prepared to investigate the effects of paclitaxel (PTX) and curcumin (CUR) combination therapy on breast cancer. Cyclic (arginine-glycine-aspartic acid-phenylalanine-lysine) (cRGDfK) was selected as a ligand for breast cancer and conjugated to the end of NPs (cRGDfK-NPs). For fluorescence imaging, sulfo-cyanine 5.5 (Cy5.5) was incorporated into NPs (Cy5.5-NPs). A series of hybrid NPs consisting of NPs, cRGDfK-NPs, and Cy5.5-NPs with drugs encapsulated inside the core (Cy5.5-cRGDfK-NPs/PTX + CUR) were prepared by self-assembly. The efficacy of PTX and CUR combination and the ability of the integrin-mediated targeting of NPs were systemically investigated using a 4T1 mouse breast cancer cell line and a nude mouse xenograft model. We suggested that Cy5.5-cRGDfK-NPs/PTX + CUR has superior theranostic potential against breast carcinoma.

AB - In this study, integrin-mediated targeting and near-infrared fluorescence (NIRF) traceable polyethylene glycol-b-poly(lactic-co-glycolic acid) (PEG-PLGA)-based polymeric nanoparticles (NPs) were prepared to investigate the effects of paclitaxel (PTX) and curcumin (CUR) combination therapy on breast cancer. Cyclic (arginine-glycine-aspartic acid-phenylalanine-lysine) (cRGDfK) was selected as a ligand for breast cancer and conjugated to the end of NPs (cRGDfK-NPs). For fluorescence imaging, sulfo-cyanine 5.5 (Cy5.5) was incorporated into NPs (Cy5.5-NPs). A series of hybrid NPs consisting of NPs, cRGDfK-NPs, and Cy5.5-NPs with drugs encapsulated inside the core (Cy5.5-cRGDfK-NPs/PTX + CUR) were prepared by self-assembly. The efficacy of PTX and CUR combination and the ability of the integrin-mediated targeting of NPs were systemically investigated using a 4T1 mouse breast cancer cell line and a nude mouse xenograft model. We suggested that Cy5.5-cRGDfK-NPs/PTX + CUR has superior theranostic potential against breast carcinoma.

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Theranostic potential of biodegradable polymeric nanoparticles with paclitaxel and curcumin against breast carcinoma

Abstract

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