Abstract
The clustered regularly interspaced palindromic repeat (CRISPR)-Cas system has revolutionized genetic engineering due to its simplicity, stability, and precision since its discovery. This technology is utilized in a variety of fields, from basic research in medicine and biology to medical diagnosis and treatment, and its potential is unbounded as new methods are developed. The review focused on medical applications and discussed the most recent treatment trends and limitations, with an emphasis on CRISPR-based therapeutics for infectious disease, oncology, and genetic disease, as well as CRISPR-based diagnostics, screening, immunotherapy, and cell therapy. Given its promising results, the successful implementation of the CRISPR-Cas system in clinical practice will require further investigation into its therapeutic applications.
| Original language | English |
|---|---|
| Article number | 477 |
| Journal | Bioengineering |
| Volume | 9 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2022 |
Bibliographical note
Funding Information:This work was supported by the National Research Foundation of Korea (NRF) through a grant funded by the Korean government (MSIT) [grant number 2017R1E1A1A01078335 and 2022R1A2C1092956] and the Institute of Clinical Medicine Research in the Yeouido St. Mary’s Hospital.
Publisher Copyright:
© 2022 by the authors.
Keywords
- Cas13
- cell therapy
- CRISPR-Cas9
- gene editing
- Immunotherapy
