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Therapeutic Applications of the CRISPR-Cas System

  • The Catholic University of Korea, College of Medicine

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

The clustered regularly interspaced palindromic repeat (CRISPR)-Cas system has revolutionized genetic engineering due to its simplicity, stability, and precision since its discovery. This technology is utilized in a variety of fields, from basic research in medicine and biology to medical diagnosis and treatment, and its potential is unbounded as new methods are developed. The review focused on medical applications and discussed the most recent treatment trends and limitations, with an emphasis on CRISPR-based therapeutics for infectious disease, oncology, and genetic disease, as well as CRISPR-based diagnostics, screening, immunotherapy, and cell therapy. Given its promising results, the successful implementation of the CRISPR-Cas system in clinical practice will require further investigation into its therapeutic applications.

Original languageEnglish
Article number477
JournalBioengineering
Volume9
Issue number9
DOIs
StatePublished - Sep 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • CRISPR-Cas9
  • Cas13
  • Immunotherapy
  • cell therapy
  • gene editing

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