TNFB polymorphism may be associated with schizophrenia in the Korean population

Tae Youn Jun; Chi Un Pae; Jeong Ho Chae; Won Myong Bahk; Kwang Soo Kim; Hoon Han; Alessandro Serretti

doi:10.1016/S0920-9964(02)00303-1

TNFB polymorphism may be associated with schizophrenia in the Korean population

Tae Youn Jun, Chi Un Pae, Jeong Ho Chae, Won Myong Bahk, Kwang Soo Kim, Hoon Han, Alessandro Serretti

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

This study was conducted to test the association between the tumor necrosis factor (TNF)-β gene (B) polymorphism and schizophrenia in the Korean population. 127 patients with schizophrenia according to the DSM-IV criteria and 202 healthy controls were enrolled in this study. Patients and controls were biologically unrelated age and sex-matched native Koreans. Genotyping for the TNFB polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele distributions of the TNFB polymorphism in patients with schizophrenia were significantly different from those of the controls. Subjects with the TNFB*2 allele had an increased risk for schizophrenia (Odds Ratio=1.76, 95% CI=1.27-2.45). The present study suggests that the TNFB polymorphism may confer susceptibility to schizophrenia in the Korean population.

Original language	English
Pages (from-to)	39-45
Number of pages	7
Journal	Schizophrenia Research
Volume	61
Issue number	1
DOIs	https://doi.org/10.1016/S0920-9964(02)00303-1
State	Published - 1 May 2003

Bibliographical note

Funding Information:
This study was supported by a grant from the Korea Health 21 R&D Project (HMP-00-GN-01-0002), The Ministry of Health and Welfare, Republic of Korea. The authors thank Ms. Young-Mi Park and Hee-Ok Kim for their support in this study.

Keywords

Association study
Schizophrenia
TNFB polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0920-9964(02)00303-1

Cite this

@article{a13b9d61a98a4a82bd2651194c50311e,

title = "TNFB polymorphism may be associated with schizophrenia in the Korean population",

abstract = "This study was conducted to test the association between the tumor necrosis factor (TNF)-β gene (B) polymorphism and schizophrenia in the Korean population. 127 patients with schizophrenia according to the DSM-IV criteria and 202 healthy controls were enrolled in this study. Patients and controls were biologically unrelated age and sex-matched native Koreans. Genotyping for the TNFB polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele distributions of the TNFB polymorphism in patients with schizophrenia were significantly different from those of the controls. Subjects with the TNFB*2 allele had an increased risk for schizophrenia (Odds Ratio=1.76, 95% CI=1.27-2.45). The present study suggests that the TNFB polymorphism may confer susceptibility to schizophrenia in the Korean population.",

keywords = "Association study, Schizophrenia, TNFB polymorphism",

author = "Jun, {Tae Youn} and Pae, {Chi Un} and Chae, {Jeong Ho} and Bahk, {Won Myong} and Kim, {Kwang Soo} and Hoon Han and Alessandro Serretti",

note = "Funding Information: This study was supported by a grant from the Korea Health 21 R&D Project (HMP-00-GN-01-0002), The Ministry of Health and Welfare, Republic of Korea. The authors thank Ms. Young-Mi Park and Hee-Ok Kim for their support in this study.",

year = "2003",

month = may,

day = "1",

doi = "10.1016/S0920-9964(02)00303-1",

language = "English",

volume = "61",

pages = "39--45",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - TNFB polymorphism may be associated with schizophrenia in the Korean population

AU - Jun, Tae Youn

AU - Pae, Chi Un

AU - Chae, Jeong Ho

AU - Bahk, Won Myong

AU - Kim, Kwang Soo

AU - Han, Hoon

AU - Serretti, Alessandro

N1 - Funding Information: This study was supported by a grant from the Korea Health 21 R&D Project (HMP-00-GN-01-0002), The Ministry of Health and Welfare, Republic of Korea. The authors thank Ms. Young-Mi Park and Hee-Ok Kim for their support in this study.

PY - 2003/5/1

Y1 - 2003/5/1

N2 - This study was conducted to test the association between the tumor necrosis factor (TNF)-β gene (B) polymorphism and schizophrenia in the Korean population. 127 patients with schizophrenia according to the DSM-IV criteria and 202 healthy controls were enrolled in this study. Patients and controls were biologically unrelated age and sex-matched native Koreans. Genotyping for the TNFB polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele distributions of the TNFB polymorphism in patients with schizophrenia were significantly different from those of the controls. Subjects with the TNFB*2 allele had an increased risk for schizophrenia (Odds Ratio=1.76, 95% CI=1.27-2.45). The present study suggests that the TNFB polymorphism may confer susceptibility to schizophrenia in the Korean population.

AB - This study was conducted to test the association between the tumor necrosis factor (TNF)-β gene (B) polymorphism and schizophrenia in the Korean population. 127 patients with schizophrenia according to the DSM-IV criteria and 202 healthy controls were enrolled in this study. Patients and controls were biologically unrelated age and sex-matched native Koreans. Genotyping for the TNFB polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele distributions of the TNFB polymorphism in patients with schizophrenia were significantly different from those of the controls. Subjects with the TNFB*2 allele had an increased risk for schizophrenia (Odds Ratio=1.76, 95% CI=1.27-2.45). The present study suggests that the TNFB polymorphism may confer susceptibility to schizophrenia in the Korean population.

KW - Association study

KW - Schizophrenia

KW - TNFB polymorphism

UR - http://www.scopus.com/inward/record.url?scp=0037400953&partnerID=8YFLogxK

U2 - 10.1016/S0920-9964(02)00303-1

DO - 10.1016/S0920-9964(02)00303-1

M3 - Article

C2 - 12648734

AN - SCOPUS:0037400953

SN - 0920-9964

VL - 61

SP - 39

EP - 45

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1

ER -

TNFB polymorphism may be associated with schizophrenia in the Korean population

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this