TNFB polymorphism may be associated with schizophrenia in the Korean population

Tae Youn Jun; Chi Un Pae; Jeong Ho Chae; Won Myong Bahk; Kwang Soo Kim; Hoon Han; Alessandro Serretti

doi:10.1016/S0920-9964(02)00303-1

TNFB polymorphism may be associated with schizophrenia in the Korean population

Tae Youn Jun
, Chi Un Pae
, Jeong Ho Chae
, Won Myong Bahk
, Kwang Soo Kim
, Hoon Han
, Alessandro Serretti

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

This study was conducted to test the association between the tumor necrosis factor (TNF)-β gene (B) polymorphism and schizophrenia in the Korean population. 127 patients with schizophrenia according to the DSM-IV criteria and 202 healthy controls were enrolled in this study. Patients and controls were biologically unrelated age and sex-matched native Koreans. Genotyping for the TNFB polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele distributions of the TNFB polymorphism in patients with schizophrenia were significantly different from those of the controls. Subjects with the TNFB*2 allele had an increased risk for schizophrenia (Odds Ratio=1.76, 95% CI=1.27-2.45). The present study suggests that the TNFB polymorphism may confer susceptibility to schizophrenia in the Korean population.

Original language	English
Pages (from-to)	39-45
Number of pages	7
Journal	Schizophrenia Research
Volume	61
Issue number	1
DOIs	https://doi.org/10.1016/S0920-9964(02)00303-1
State	Published - 1 May 2003

Bibliographical note

Funding Information:
This study was supported by a grant from the Korea Health 21 R&D Project (HMP-00-GN-01-0002), The Ministry of Health and Welfare, Republic of Korea. The authors thank Ms. Young-Mi Park and Hee-Ok Kim for their support in this study.

Keywords

Association study
Schizophrenia
TNFB polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0920-9964(02)00303-1

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title = "TNFB polymorphism may be associated with schizophrenia in the Korean population",

abstract = "This study was conducted to test the association between the tumor necrosis factor (TNF)-β gene (B) polymorphism and schizophrenia in the Korean population. 127 patients with schizophrenia according to the DSM-IV criteria and 202 healthy controls were enrolled in this study. Patients and controls were biologically unrelated age and sex-matched native Koreans. Genotyping for the TNFB polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele distributions of the TNFB polymorphism in patients with schizophrenia were significantly different from those of the controls. Subjects with the TNFB*2 allele had an increased risk for schizophrenia (Odds Ratio=1.76, 95\% CI=1.27-2.45). The present study suggests that the TNFB polymorphism may confer susceptibility to schizophrenia in the Korean population.",

keywords = "Association study, Schizophrenia, TNFB polymorphism",

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note = "Funding Information: This study was supported by a grant from the Korea Health 21 R\&D Project (HMP-00-GN-01-0002), The Ministry of Health and Welfare, Republic of Korea. The authors thank Ms. Young-Mi Park and Hee-Ok Kim for their support in this study.",

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doi = "10.1016/S0920-9964(02)00303-1",

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T1 - TNFB polymorphism may be associated with schizophrenia in the Korean population

AU - Jun, Tae Youn

AU - Pae, Chi Un

AU - Chae, Jeong Ho

AU - Bahk, Won Myong

AU - Kim, Kwang Soo

AU - Han, Hoon

AU - Serretti, Alessandro

N1 - Funding Information: This study was supported by a grant from the Korea Health 21 R&D Project (HMP-00-GN-01-0002), The Ministry of Health and Welfare, Republic of Korea. The authors thank Ms. Young-Mi Park and Hee-Ok Kim for their support in this study.

PY - 2003/5/1

Y1 - 2003/5/1

N2 - This study was conducted to test the association between the tumor necrosis factor (TNF)-β gene (B) polymorphism and schizophrenia in the Korean population. 127 patients with schizophrenia according to the DSM-IV criteria and 202 healthy controls were enrolled in this study. Patients and controls were biologically unrelated age and sex-matched native Koreans. Genotyping for the TNFB polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele distributions of the TNFB polymorphism in patients with schizophrenia were significantly different from those of the controls. Subjects with the TNFB*2 allele had an increased risk for schizophrenia (Odds Ratio=1.76, 95% CI=1.27-2.45). The present study suggests that the TNFB polymorphism may confer susceptibility to schizophrenia in the Korean population.

AB - This study was conducted to test the association between the tumor necrosis factor (TNF)-β gene (B) polymorphism and schizophrenia in the Korean population. 127 patients with schizophrenia according to the DSM-IV criteria and 202 healthy controls were enrolled in this study. Patients and controls were biologically unrelated age and sex-matched native Koreans. Genotyping for the TNFB polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele distributions of the TNFB polymorphism in patients with schizophrenia were significantly different from those of the controls. Subjects with the TNFB*2 allele had an increased risk for schizophrenia (Odds Ratio=1.76, 95% CI=1.27-2.45). The present study suggests that the TNFB polymorphism may confer susceptibility to schizophrenia in the Korean population.

KW - Association study

KW - Schizophrenia

KW - TNFB polymorphism

UR - https://www.scopus.com/pages/publications/0037400953

U2 - 10.1016/S0920-9964(02)00303-1

DO - 10.1016/S0920-9964(02)00303-1

M3 - Article

C2 - 12648734

AN - SCOPUS:0037400953

SN - 0920-9964

VL - 61

SP - 39

EP - 45

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1

ER -

TNFB polymorphism may be associated with schizophrenia in the Korean population

Abstract

Bibliographical note

Keywords

UN SDGs

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