Abstract
This article describes enhanced skin permeation and UV/thermal stability of retinol emulsions by the co-stabilisation of Tween20 and biodegradable poly(ethylene oxide)-block-poly(ε-caprolactone)-block-poly(ethylene oxide) (PEO-PCL-PEO) triblock copolymers having different lengths of hydrophobic PCL block. A triblock copolymer with a longer PCL block has a lower hydrophile-lipophile balance (HLB) value. Commercial Retinol 50C® (BASF Co., Ludwigshafen, Germany) was used as the source of retinol. Ultrasonication of the Retinol 50C® emulsion with the triblock copolymers led to an increase in retinol solubilisation and a decrease in average particle size of the resulting retinol emulsion. These characteristics improved skin permeation of retinol through the stratum corneum of artificial skin and subsequent proliferation of viable epidermis cell. Employment of the triblock copolymer with a longer PCL block increased both UV and thermal stabilization of the retinol. These results suggest that HLB and PCL block length are important factors to enhance the topical delivery of retinol into the skin.
| Original language | English |
|---|---|
| Pages (from-to) | 739-746 |
| Number of pages | 8 |
| Journal | Journal of Microencapsulation |
| Volume | 29 |
| Issue number | 8 |
| DOIs | |
| State | Published - Dec 2012 |
Bibliographical note
Funding Information:This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010-0012479 and 2011-0023064), the Fundamental R&D Program for Core Technology of Materials funded by the Ministry of Knowledge Economy, Republic of Korea (K0006005), a grant of the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A110416), and the Research Grant funded by the Gyeonggi Regional Research Center (GRRC).
Keywords
- Biodegradable polymers
- Encapsulation
- Retinol
- Transdermal drug delivery