TT virus infection among blood donors and patients with non-B, non-C liver diseases in Korea

Tatsunori Nakano; Young Min Park; Masashi Mizokami; Jong Young Choi; Etsuro Orito; Tomoyoshi Ohno; Takanobu Kato; Yutaka Kondo; Yasuhito Tanaka; Hideaki Kato; Tetsuo Kato; Boo Sung Kim

doi:10.1016/S0168-8278(99)80095-6

TT virus infection among blood donors and patients with non-B, non-C liver diseases in Korea

Tatsunori Nakano, Young Min Park, Masashi Mizokami, Jong Young Choi, Etsuro Orito, Tomoyoshi Ohno, Takanobu Kato, Yutaka Kondo, Yasuhito Tanaka, Hideaki Kato, Tetsuo Kato, Boo Sung Kim

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Background/Aims: A novel virus, designated the TT virus (TTV), was isolated from the serum of a patient with posttransfusion hepatitis of unknown etiology, in Japan. Subsequently, TTV was suggested to be a causative agent in a proportion of cases with cryptogenic hepatitis in Japan. This study aimed to elucidate the significance of TTV infection in cases with cryptogenic liver disease in Korea, a neighbor of Japan. Methods: The prevalence of TTV infection was studied in 120 patients with liver diseases, including 85 patients diagnosed as having non-B, non-C liver diseases. As controls, 220 blood donors were also examined. TTV DNA was detected by polymerase chain reaction, and the sequence was analyzed by phylogenetic analysis. Results: Fourteen (14.0%) of 100 accepted blood donors, 23 (19.2%) of 120 rejected blood donors, and 15 (17.6%) of 85 patients with non-B, non- C liver diseases were positive for TTV DNA. The prevalences of TTV infection among these groups were not significantly different. Phylogenetic analysis suggested the existence of four major genotypes of TTV. The proportions of each genotype among patients with non-B, non-C liver diseases were not different from those among accepted blood donors. Conclusions: TTV exists in Korea, but the prevalence among patients with non-B, non-C liver diseases was almost the same as that among blood donors. TTV may not be the main causative agent of cryptogenic liver disease in Korea. The relationship between non-B, non-C liver diseases and TTV genotype remains unclear, although TTV can be classified into four genotypes.

Original language	English
Pages (from-to)	389-393
Number of pages	5
Journal	Journal of Hepatology
Volume	30
Issue number	3
DOIs	https://doi.org/10.1016/S0168-8278(99)80095-6
State	Published - Mar 1999

Bibliographical note

Funding Information:
M. Mizokami was supported in part by a Grant-in-Aid for Scientific Research (06670571) from the Japanese Ministry of Education, Science, Sports, and Culture, and grants from the Japanese Ministry of Health and Welfare, Health Science Research Grants (Non-A, non-B Hepatitis Research Grants) and the Viral Hepatitis Research Foundation of Japan. Y.-M. Park was supported in part by a grant for health scientific research from the Korean Ministry of Health and Welfare (HMP-56-M-0037) and in part by grant for the Medical Science Research Foundation from the Catholic Medical Center of Korea.

Keywords

Blood donor
Genotype
Korea
Non-B, non-C liver disease
TT virus (TTV)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0168-8278(99)80095-6

Cite this

@article{8eb478c8292547a89f0b4c1de7c36b31,

title = "TT virus infection among blood donors and patients with non-B, non-C liver diseases in Korea",

abstract = "Background/Aims: A novel virus, designated the TT virus (TTV), was isolated from the serum of a patient with posttransfusion hepatitis of unknown etiology, in Japan. Subsequently, TTV was suggested to be a causative agent in a proportion of cases with cryptogenic hepatitis in Japan. This study aimed to elucidate the significance of TTV infection in cases with cryptogenic liver disease in Korea, a neighbor of Japan. Methods: The prevalence of TTV infection was studied in 120 patients with liver diseases, including 85 patients diagnosed as having non-B, non-C liver diseases. As controls, 220 blood donors were also examined. TTV DNA was detected by polymerase chain reaction, and the sequence was analyzed by phylogenetic analysis. Results: Fourteen (14.0%) of 100 accepted blood donors, 23 (19.2%) of 120 rejected blood donors, and 15 (17.6%) of 85 patients with non-B, non- C liver diseases were positive for TTV DNA. The prevalences of TTV infection among these groups were not significantly different. Phylogenetic analysis suggested the existence of four major genotypes of TTV. The proportions of each genotype among patients with non-B, non-C liver diseases were not different from those among accepted blood donors. Conclusions: TTV exists in Korea, but the prevalence among patients with non-B, non-C liver diseases was almost the same as that among blood donors. TTV may not be the main causative agent of cryptogenic liver disease in Korea. The relationship between non-B, non-C liver diseases and TTV genotype remains unclear, although TTV can be classified into four genotypes.",

keywords = "Blood donor, Genotype, Korea, Non-B, non-C liver disease, TT virus (TTV)",

author = "Tatsunori Nakano and Park, {Young Min} and Masashi Mizokami and Choi, {Jong Young} and Etsuro Orito and Tomoyoshi Ohno and Takanobu Kato and Yutaka Kondo and Yasuhito Tanaka and Hideaki Kato and Tetsuo Kato and Kim, {Boo Sung}",

note = "Funding Information: M. Mizokami was supported in part by a Grant-in-Aid for Scientific Research (06670571) from the Japanese Ministry of Education, Science, Sports, and Culture, and grants from the Japanese Ministry of Health and Welfare, Health Science Research Grants (Non-A, non-B Hepatitis Research Grants) and the Viral Hepatitis Research Foundation of Japan. Y.-M. Park was supported in part by a grant for health scientific research from the Korean Ministry of Health and Welfare (HMP-56-M-0037) and in part by grant for the Medical Science Research Foundation from the Catholic Medical Center of Korea.",

year = "1999",

month = mar,

doi = "10.1016/S0168-8278(99)80095-6",

language = "English",

volume = "30",

pages = "389--393",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - TT virus infection among blood donors and patients with non-B, non-C liver diseases in Korea

AU - Nakano, Tatsunori

AU - Park, Young Min

AU - Mizokami, Masashi

AU - Choi, Jong Young

AU - Orito, Etsuro

AU - Ohno, Tomoyoshi

AU - Kato, Takanobu

AU - Kondo, Yutaka

AU - Tanaka, Yasuhito

AU - Kato, Hideaki

AU - Kato, Tetsuo

AU - Kim, Boo Sung

N1 - Funding Information: M. Mizokami was supported in part by a Grant-in-Aid for Scientific Research (06670571) from the Japanese Ministry of Education, Science, Sports, and Culture, and grants from the Japanese Ministry of Health and Welfare, Health Science Research Grants (Non-A, non-B Hepatitis Research Grants) and the Viral Hepatitis Research Foundation of Japan. Y.-M. Park was supported in part by a grant for health scientific research from the Korean Ministry of Health and Welfare (HMP-56-M-0037) and in part by grant for the Medical Science Research Foundation from the Catholic Medical Center of Korea.

PY - 1999/3

Y1 - 1999/3

N2 - Background/Aims: A novel virus, designated the TT virus (TTV), was isolated from the serum of a patient with posttransfusion hepatitis of unknown etiology, in Japan. Subsequently, TTV was suggested to be a causative agent in a proportion of cases with cryptogenic hepatitis in Japan. This study aimed to elucidate the significance of TTV infection in cases with cryptogenic liver disease in Korea, a neighbor of Japan. Methods: The prevalence of TTV infection was studied in 120 patients with liver diseases, including 85 patients diagnosed as having non-B, non-C liver diseases. As controls, 220 blood donors were also examined. TTV DNA was detected by polymerase chain reaction, and the sequence was analyzed by phylogenetic analysis. Results: Fourteen (14.0%) of 100 accepted blood donors, 23 (19.2%) of 120 rejected blood donors, and 15 (17.6%) of 85 patients with non-B, non- C liver diseases were positive for TTV DNA. The prevalences of TTV infection among these groups were not significantly different. Phylogenetic analysis suggested the existence of four major genotypes of TTV. The proportions of each genotype among patients with non-B, non-C liver diseases were not different from those among accepted blood donors. Conclusions: TTV exists in Korea, but the prevalence among patients with non-B, non-C liver diseases was almost the same as that among blood donors. TTV may not be the main causative agent of cryptogenic liver disease in Korea. The relationship between non-B, non-C liver diseases and TTV genotype remains unclear, although TTV can be classified into four genotypes.

AB - Background/Aims: A novel virus, designated the TT virus (TTV), was isolated from the serum of a patient with posttransfusion hepatitis of unknown etiology, in Japan. Subsequently, TTV was suggested to be a causative agent in a proportion of cases with cryptogenic hepatitis in Japan. This study aimed to elucidate the significance of TTV infection in cases with cryptogenic liver disease in Korea, a neighbor of Japan. Methods: The prevalence of TTV infection was studied in 120 patients with liver diseases, including 85 patients diagnosed as having non-B, non-C liver diseases. As controls, 220 blood donors were also examined. TTV DNA was detected by polymerase chain reaction, and the sequence was analyzed by phylogenetic analysis. Results: Fourteen (14.0%) of 100 accepted blood donors, 23 (19.2%) of 120 rejected blood donors, and 15 (17.6%) of 85 patients with non-B, non- C liver diseases were positive for TTV DNA. The prevalences of TTV infection among these groups were not significantly different. Phylogenetic analysis suggested the existence of four major genotypes of TTV. The proportions of each genotype among patients with non-B, non-C liver diseases were not different from those among accepted blood donors. Conclusions: TTV exists in Korea, but the prevalence among patients with non-B, non-C liver diseases was almost the same as that among blood donors. TTV may not be the main causative agent of cryptogenic liver disease in Korea. The relationship between non-B, non-C liver diseases and TTV genotype remains unclear, although TTV can be classified into four genotypes.

KW - Blood donor

KW - Genotype

KW - Korea

KW - Non-B, non-C liver disease

KW - TT virus (TTV)

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U2 - 10.1016/S0168-8278(99)80095-6

DO - 10.1016/S0168-8278(99)80095-6

M3 - Article

C2 - 10190719

AN - SCOPUS:0033065555

SN - 0168-8278

VL - 30

SP - 389

EP - 393

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 3

ER -

TT virus infection among blood donors and patients with non-B, non-C liver diseases in Korea

Abstract

Bibliographical note

Keywords

UN SDGs

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