Tumor necrosis factor-α gene polymorphism at position -308 and schizophrenia in the Korean population

Chi Un Pae; Jeong Ho Chae; Won Myong Bahk; Hoon Han; Tae Youn Jun; Kwang Soo Kim; Yong Sil Kwon; Alessandro Serretti

doi:10.1046/j.1440-1819.2003.01138.x

Tumor necrosis factor-α gene polymorphism at position -308 and schizophrenia in the Korean population

Chi Un Pae
, Jeong Ho Chae
, Won Myong Bahk
, Hoon Han
, Tae Youn Jun
, Kwang Soo Kim
, Yong Sil Kwon
, Alessandro Serretti

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The purpose of the present study was to examine the association between the tumor necrosis factor (TNF)-α gene (A) polymorphism and schizophrenia in a Korean sample of schizophrenic patients and control subjects. Genotyping for the TNFA polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele distributions of the TNFA polymorphism between schizophrenic patients and controls were not significantly different. In the light of these results, the TNFA polymorphism seems not to confer susceptibility to the pathogenesis of schizophrenia, at least in the Korean population.

Original language	English
Pages (from-to)	399-403
Number of pages	5
Journal	Psychiatry and Clinical Neurosciences
Volume	57
Issue number	4
DOIs	https://doi.org/10.1046/j.1440-1819.2003.01138.x
State	Published - Aug 2003

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Association study
Schizophrenia
Tumor necrosis factor-α gene polymorphism

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10.1046/j.1440-1819.2003.01138.x

Cite this

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title = "Tumor necrosis factor-α gene polymorphism at position -308 and schizophrenia in the Korean population",

abstract = "The purpose of the present study was to examine the association between the tumor necrosis factor (TNF)-α gene (A) polymorphism and schizophrenia in a Korean sample of schizophrenic patients and control subjects. Genotyping for the TNFA polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele distributions of the TNFA polymorphism between schizophrenic patients and controls were not significantly different. In the light of these results, the TNFA polymorphism seems not to confer susceptibility to the pathogenesis of schizophrenia, at least in the Korean population.",

keywords = "Association study, Schizophrenia, Tumor necrosis factor-α gene polymorphism",

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doi = "10.1046/j.1440-1819.2003.01138.x",

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T1 - Tumor necrosis factor-α gene polymorphism at position -308 and schizophrenia in the Korean population

AU - Pae, Chi Un

AU - Chae, Jeong Ho

AU - Bahk, Won Myong

AU - Han, Hoon

AU - Jun, Tae Youn

AU - Kim, Kwang Soo

AU - Kwon, Yong Sil

AU - Serretti, Alessandro

PY - 2003/8

Y1 - 2003/8

N2 - The purpose of the present study was to examine the association between the tumor necrosis factor (TNF)-α gene (A) polymorphism and schizophrenia in a Korean sample of schizophrenic patients and control subjects. Genotyping for the TNFA polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele distributions of the TNFA polymorphism between schizophrenic patients and controls were not significantly different. In the light of these results, the TNFA polymorphism seems not to confer susceptibility to the pathogenesis of schizophrenia, at least in the Korean population.

AB - The purpose of the present study was to examine the association between the tumor necrosis factor (TNF)-α gene (A) polymorphism and schizophrenia in a Korean sample of schizophrenic patients and control subjects. Genotyping for the TNFA polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele distributions of the TNFA polymorphism between schizophrenic patients and controls were not significantly different. In the light of these results, the TNFA polymorphism seems not to confer susceptibility to the pathogenesis of schizophrenia, at least in the Korean population.

KW - Association study

KW - Schizophrenia

KW - Tumor necrosis factor-α gene polymorphism

UR - https://www.scopus.com/pages/publications/0041654612

U2 - 10.1046/j.1440-1819.2003.01138.x

DO - 10.1046/j.1440-1819.2003.01138.x

M3 - Article

C2 - 12839521

AN - SCOPUS:0041654612

SN - 1323-1316

VL - 57

SP - 399

EP - 403

JO - Psychiatry and Clinical Neurosciences

JF - Psychiatry and Clinical Neurosciences

IS - 4

ER -

Tumor necrosis factor-α gene polymorphism at position -308 and schizophrenia in the Korean population

Abstract

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Keywords

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